Suchergebnisse - "Current controlled trials in cardiovascular medicine"

The COMET Handbook: version 1.0 von Williamson, Paula R., Altman, Douglas G., Bagley, Heather, Barnes, Karen L., Blazeby, Jane M., Brookes, Sara T., Clarke, Mike, Gargon, Elizabeth, Gorst, Sarah, Harman, Nicola, Kirkham, Jamie J., McNair, Angus, Prinsen, Cecilia A. C., Schmitt, Jochen, Terwee, Caroline B., Young, Bridget

“… The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the …”
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The role of machine learning in clinical research: transforming the future of evidence generation von Weissler, E. Hope, Naumann, Tristan, Andersson, Tomas, Ranganath, Rajesh, Elemento, Olivier, Luo, Yuan, Freitag, Daniel F., Benoit, James, Hughes, Michael C., Khan, Faisal, Slater, Paul, Shameer, Khader, Roe, Matthew, Hutchison, Emmette, Kollins, Scott H., Broedl, Uli, Meng, Zhaoling, Wong, Jennifer L., Curtis, Lesley, Huang, Erich, Ghassemi, Marzyeh

“… Background Interest in the application of machine learning (ML) to the design, conduct, and analysis of clinical trials has grown, but the evidence base for …”
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Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols von Park, Jay J. H, Siden, Ellie, Zoratti, Michael J., Dron, Louis, Harari, Ofir, Singer, Joel, Lester, Richard T., Thorlund, Kristian, Mills, Edward J.

“… Background Master protocols, classified as basket trials, umbrella trials, and platform trials, are novel designs that investigate multiple hypotheses through …”
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How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline von Prinsen, Cecilia A. C., Vohra, Sunita, Rose, Michael R., Boers, Maarten, Tugwell, Peter, Clarke, Mike, Williamson, Paula R., Terwee, Caroline B.

“… Background In cooperation with the Core Outcome Measures in Effectiveness Trials (COMET) initiative, the COnsensus-based Standards for the selection of health …”
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Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac – PROFISCOV: A structured summary of a study protocol for a randomised controlled trial von Palacios, Ricardo, Patiño, Elizabeth González, de Oliveira Piorelli, Roberta, Conde, Monica Tilli Reis Pessoa, Batista, Ana Paula, Zeng, Gang, Xin, Qianqian, Kallas, Esper G., Flores, Jorge, Ockenhouse, Christian F., Gast, Christopher

“… Objectives To evaluate the efficacy of two doses of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac in symptomatic individuals, with …”
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Promoting inclusion in clinical trials—a rapid review of the literature and recommendations for action von Bodicoat, Danielle H., Routen, Ash C., Willis, Andrew, Ekezie, Winifred, Gillies, Clare, Lawson, Claire, Yates, Thomas, Zaccardi, Francesco, Davies, Melanie J., Khunti, Kamlesh

“… Background Without inclusion of diverse research participants, it is challenging to understand how study findings will translate into the real world. Despite …”
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A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results von Kennedy-Martin, Tessa, Curtis, Sarah, Faries, Douglas, Robinson, Susan, Johnston, Joseph

“… Randomized controlled trials (RCTs) are conducted under idealized and rigorously controlled conditions that may compromise their external validity. A …”
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Reporting randomised trials of social and psychological interventions: the CONSORT-SPI 2018 Extension von Montgomery, Paul, Grant, Sean, Mayo-Wilson, Evan, Macdonald, Geraldine, Michie, Susan, Hopewell, Sally, Moher, David

“… Background Randomised controlled trials (RCTs) are used to evaluate social and psychological interventions and inform policy decisions about them. Accurate, …”
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The reality of informed consent: empirical studies on patient comprehension—systematic review von Pietrzykowski, Tomasz, Smilowska, Katarzyna

“… Background Informed consent is a basic concept of contemporary, autonomy-based medical practice and facilitates a shared decision-making model for relations …”
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Developing a roadmap to improve trial delivery for under-served groups: results from a UK multi-stakeholder process von Witham, Miles D., Anderson, Eleanor, Carroll, Camille, Dark, Paul M., Down, Kim, Hall, Alistair S., Knee, Joanna, Maier, Rebecca H., Mountain, Gail A., Nestor, Gary, Oliva, Laurie, Prowse, Sarah R., Tortice, Amanda, Wason, James, Rochester, Lynn

“… Background Participants in clinical research studies often do not reflect the populations for which healthcare interventions are needed or will be used …”
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CONSORT-SPI 2018 Explanation and Elaboration: guidance for reporting social and psychological intervention trials von Grant, Sean, Mayo-Wilson, Evan, Montgomery, Paul, Macdonald, Geraldine, Michie, Susan, Hopewell, Sally, Moher, David

“… Background The CONSORT (Consolidated Standards of Reporting Trials) Statement was developed to help biomedical researchers report randomised controlled trials …”
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Pulmonary Metastasectomy versus Continued Active Monitoring in Colorectal Cancer (PulMiCC): a multicentre randomised clinical trial von Treasure, Tom, Farewell, Vern, Macbeth, Fergus, Monson, Kathryn, Williams, Norman R, Brew-Graves, Chris, Lees, Belinda, Grigg, Olivia, Fallowfield, Lesley

“… Background Lung metastasectomy in the treatment of advanced colorectal cancer has been widely adopted without good evidence of survival or palliative benefit …”
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Core Outcome Set-STAndardised Protocol Items: the COS-STAP Statement von Kirkham, Jamie J., Gorst, Sarah, Altman, Douglas G., Blazeby, Jane M., Clarke, Mike, Tunis, Sean, Williamson, Paula R.

“… Background Several hundred core outcome set (COS) projects have been systematically identified to date which, if adopted, ensure that researchers measure and …”
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Blockchain technology for improving clinical research quality von Benchoufi, Mehdi, Ravaud, Philippe

“… Reproducibility, data sharing, personal data privacy concerns and patient enrolment in clinical trials are huge medical challenges for contemporary clinical …”
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Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial von Arabi, Yaseen M., Alothman, Adel, Balkhy, Hanan H., Al-Dawood, Abdulaziz, AlJohani, Sameera, Al Harbi, Shmeylan, Kojan, Suleiman, Al Jeraisy, Majed, Deeb, Ahmad M., Assiri, Abdullah M., Al-Hameed, Fahad, AlSaedi, Asim, Mandourah, Yasser, Almekhlafi, Ghaleb A., Sherbeeni, Nisreen Murad, Elzein, Fatehi Elnour, Memon, Javed, Taha, Yusri, Almotairi, Abdullah, Maghrabi, Khalid A., Qushmaq, Ismael, Al Bshabshe, Ali, Kharaba, Ayman, Shalhoub, Sarah, Jose, Jesna, Fowler, Robert A., Hayden, Frederick G., Hussein, Mohamed A.

“… Background It had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no …”
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Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study) von Femminella, Grazia Daniela, Frangou, Eleni, Love, Sharon B., Busza, Gail, Holmes, Clive, Ritchie, Craig, Lawrence, Robert, McFarlane, Brady, Tadros, George, Ridha, Basil H., Bannister, Carol, Walker, Zuzana, Archer, Hilary, Coulthard, Elizabeth, Underwood, Ben R., Prasanna, Aparna, Koranteng, Paul, Karim, Salman, Junaid, Kehinde, McGuinness, Bernadette, Nilforooshan, Ramin, Macharouthu, Ajay, Donaldson, Andrew, Thacker, Simon, Russell, Gregor, Malik, Naghma, Mate, Vandana, Knight, Lucy, Kshemendran, Sajeev, Harrison, John, Brooks, David J., Passmore, Anthony Peter, Ballard, Clive, Edison, Paul

“… Background Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue currently approved for type 2 diabetes and obesity. Preclinical evidence in transgenic …”
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Why clinical trial outcomes fail to translate into benefits for patients von Heneghan, Carl, Goldacre, Ben, Mahtani, Kamal R.

“… Clinical research should ultimately improve patient care. For this to be possible, trials must evaluate outcomes that genuinely reflect real-world settings and …”
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Why do patients take part in research? An overview of systematic reviews of psychosocial barriers and facilitators von Sheridan, Rebecca, Martin-Kerry, Jacqueline, Hudson, Joanna, Parker, Adwoa, Bower, Peter, Knapp, Peter

“… Background Understanding why people take part in health research is critical to improve research efficiency and generalisability. The aim of this overview of …”
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Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects von Hafliðadóttir, Sigurlaug H., Juhl, Carsten B., Nielsen, Sabrina M., Henriksen, Marius, Harris, Ian A., Bliddal, Henning, Christensen, Robin

“… Background Contextual effects (i.e., placebo response ) refer to all health changes resulting from administering an apparently inactive treatment. In a …”
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Efficacy of an online cognitive behavioral therapy program developed for healthcare workers during the COVID-19 pandemic: the REduction of STress (REST) study protocol for a randomized controlled trial von Weiner, Luisa, Berna, Fabrice, Nourry, Nathalie, Severac, François, Vidailhet, Pierre, Mengin, Amaury C.

“… Background The acknowledgment of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease evolved into a …”
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