Suchergebnisse - "Cunha, Thiago M"

CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization von Silva, Rangel L., Lopes, Alexandre H., Guimarães, Rafaela M., Cunha, Thiago M.

“… Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is associated with plasticity of nociceptive pathway in …”
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Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells von Zhang, Bing, Ma, Sai, Rachmin, Inbal, He, Megan, Baral, Pankaj, Choi, Sekyu, Gonçalves, William A., Shwartz, Yulia, Fast, Eva M., Su, Yiqun, Zon, Leonard I., Regev, Aviv, Buenrostro, Jason D., Cunha, Thiago M., Chiu, Isaac M., Fisher, David E., Hsu, Ya-Chieh

“… Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs) 1 , 2 , but so far there has been little …”
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Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner von Wanderley, Carlos W, Colón, David F, Luiz, João Paulo M, Oliveira, Francisco F, Viacava, Paula R, Leite, Caio A, Pereira, Janaina A, Silva, Camila M, Silva, Cassia R, Silva, Rangel L, Speck-Hernandez, Cesar A, Mota, José M, Alves-Filho, José C, Lima-Junior, Roberto C, Cunha, Thiago M, Cunha, Fernando Q

“… Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action of paclitaxel is based on microtubule …”
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Peripheral nitric oxide signaling directly blocks inflammatory pain von Gomes, Francisco Isaac F., Cunha, Fernando Q., Cunha, Thiago M.

“… [Display omitted] Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN) is the most important mediating mechanism. This …”
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The role of neutrophils in neuro-immune modulation von Kanashiro, Alexandre, Hiroki, Carlos Hiroji, da Fonseca, Denise Morais, Birbrair, Alexander, Ferreira, Raphael Gomes, Bassi, Gabriel Shimizu, Fonseca, Mirian D., Kusuda, Ricardo, Cebinelli, Guilherme Cesar Martelossi, da Silva, Katiussia Pinho, Wanderley, Carlos Wagner, Menezes, Gustavo Batista, Alves-Fiho, José Carlos, Oliveira, André Gustavo, Cunha, Thiago M., Pupo, André Sampaio, Ulloa, Luis, Cunha, Fernando Queiroz

“… [Display omitted] •Neutrophils are an immunological and diffuse source of neurotransmitters.•Neutrophils regulate sensory neuron functions and …”
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Fractalkine mediates inflammatory pain through activation of satellite glial cells von Souza, Guilherme R, Talbot, Jhimmy, Lotufo, Celina M, Cunha, Fernando Q, Cunha, Thiago M, Ferreira, Sérgio H

“… The activation of the satellite glial cells (SGCs) surrounding the dorsal root ganglion (DRG) neurons appears to play a role in pathological pain. We tested …”
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Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis von Titiz, Mustafa, Landini, Lorenzo, Souza Monteiro de Araujo, Daniel, Marini, Matilde, Seravalli, Viola, Chieca, Martina, Pensieri, Pasquale, Montini, Marco, De Siena, Gaetano, Pasquini, Benedetta, Vannuccini, Silvia, Iannone, Luigi Francesco, Cunha, Thiago M., Brancolini, Giulia, Bellantoni, Elisa, Scuffi, Irene, Mastricci, Alessandra, Tesi, Martina, Di Tommaso, Mariarosaria, Petraglia, Felice, Geppetti, Pierangelo, Nassini, Romina, De Logu, Francesco

“… Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic …”
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Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw von Calil, Igor L., Zarpelon, Ana C., Guerrero, Ana T. G., Alves-Filho, Jose C., Ferreira, Sergio H., Cunha, Fernando Q., Cunha, Thiago M., Verri, Waldiceu A.

“… Inflammatory pain can be triggered by different stimuli, such as trauma, radiation, antigen and infection. In a model of inflammatory pain caused by infection, …”
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Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling von Guimarães, Rafaela M, Aníbal-Silva, Conceição E, Davoli-Ferreira, Marcela, Gomes, Francisco Isaac F, Mendes, Atlante, Cavallini, Maria CM, Fonseca, Miriam M, Damasceno, Samara, Andrade, Larissa P, Colonna, Marco, Rivat, Cyril, Cunha, Fernando Q, Alves-Filho, José C, Cunha, Thiago M

“… Resident macrophages are distributed across all tissues and are highly heterogeneous due to adaptation to different tissue-specific environments. The resident …”
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Usutu virus-induced meningoencephalitis in immunocompetent mice is characterized by the recruitment of mononuclear cells and a proinflammatory T helper 1 response von Rocha, Rebeca Froes, Coimbra, Laís D., Fontoura, Marina A., Ribeiro, Guilherme, Sotorilli, Giuliana Eboli, Gomes, Giovanni F., Borin, Alexandre, Felipe, Jaqueline, Slowikowski, Emily, Greison, Wilias Silva Santos, Cunha, Thiago M., Marques, Pedro Elias, Vieira, Pedro M. M., Marques, Rafael Elias

“… Mosquito-borne viruses, including USUV, are maintained in nature through complex cycles involving arthropod vectors and vertebrate hosts. A comprehensive …”
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Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model von Veras, Flavio P., Gomes, Giovanni F., Silva, Bruna M. S., Caetité, Diego B., Almeida, Cicero J. L. R., Silva, Camila Meirelles S., Schneider, Ayda H., Corneo, Emily S., Bonilha, Caio S., Batah, Sabrina S., Martins, Ronaldo, Arruda, Eurico, Fabro, Alexandre T., Alves-Filho, José C., Cunha, Thiago M., Cunha, Fernando Q.

“… Background COVID-19 is characterized by severe acute lung injury, which is associated with neutrophil infiltration and the release of neutrophil extracellular …”
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Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia von Silva, Jaqueline R, Lopes, Alexandre H, Talbot, Jhimmy, Cecilio, Nerry T, Rossato, Mateus F, Silva, Rangel L, Souza, Guilherme R, Silva, Cassia R, Lucas, Guilherme, Fonseca, Benedito A, Arruda, Eurico, Alves-Filho, Jose C, Cunha, Fernando Q, Cunha, Thiago M

“… Herpetic neuralgia is the most important symptom of herpes zoster disease, which is caused by Nevertheless, the pathophysiological mechanisms involved in …”
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Crucial role of neutrophils in the development of mechanical inflammatory hypernociception von Cunha, Thiago M., Verri, Waldiceu A., Schivo, Ieda R., Napimoga, Marcelo H., Parada, Carlos A., Poole, Stephen, Teixeira, Mauro M., Ferreira, Sergio H., Cunha, Fernando Q.

“… Neutrophil migration is responsible for tissue damage observed in inflammatory diseases. Neutrophils are also implicated in inflammatory nociception, but …”
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Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Inflammatory and Toxic Response von Almeida, Glaucia M., Souza, Juliano P., Mendes, Niele D., Pontelli, Marjorie C., Pinheiro, Nathalia R., Nogueira, Giovanna O., Cardoso, Ricardo S., Paiva, Isadora M., Ferrari, Gustavo D., Veras, Flávio P., Cunha, Fernando Q., Horta-Junior, Jose A. C., Alberici, Luciane C., Cunha, Thiago M., Podolsky-Gondim, Guilherme G., Neder, Luciano, Arruda, Eurico, Sebollela, Adriano

“… Oropouche virus (OROV) is an emerging arbovirus in South and Central Americas with high spreading potential. OROV infection has been associated with …”
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IL-17 mediates articular hypernociception in antigen-induced arthritis in mice von Pinto, Larissa G, Cunha, Thiago M, Vieira, Silvio M, Lemos, Henrique P, Verri, Jr, Waldiceu A, Cunha, Fernando Q, Ferreira, Sergio H

“… IL-17 is an important cytokine in the physiopathology of rheumatoid arthritis (RA). However, its participation in the genesis of nociception during RA remains …”
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Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice von Pinto, Larissa G., Souza, Guilherme R., Kusuda, Ricardo, Lopes, Alexandre H., Sant’Anna, Morena B., Cunha, Fernando Q., Ferreira, Sérgio H., Cunha, Thiago M.

“… Small nerve fibers that bind the isolectin B4 (IB4 + C-fibers) are a subpopulation of primary afferent neurons that are involved in nociceptive sensory …”
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Molecular basis of carrageenan-induced cytokines production in macrophages von Lopes, Alexandre H., Silva, Rangel L., Fonseca, Miriam D., Gomes, Francisco I., Maganin, Alexandre G., Ribeiro, Lucas S., Marques, Lucas Maciel Mauriz, Cunha, Fernando Q., Alves-Filho, Jose C., Zamboni, Dario S., Lopes, Norberto P., Franklin, Bernardo S., Gombault, Aurélie, Ramalho, Fernando Silva, Quesniaux, Valerie F. J., Couillin, Isabelle, Ryffel, Bernhard, Cunha, Thiago M.

“… Background Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies …”
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Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells von Talbot, Jhimmy, Peres, Raphael S., Pinto, Larissa G., Oliveira, Rene D. R., Lima, Kalil A., Donate, Paula B., Silva, Jaqueline R., Ryffel, Bernard, Cunha, Thiago M., Alves-Filho, José C., Liew, Foo Y., Louzada-Junior, Paulo, de Queiroz Cunha, Fernando

“… Background Epidemiologic studies have highlighted the association of environmental factors with the development and progression of autoimmune and chronic …”
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Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase von Huang, Lei, Ou, Rong, Rabelo de Souza, Guilherme, Cunha, Thiago M., Lemos, Henrique, Mohamed, Eslam, Li, Lingqian, Pacholczyk, Gabriela, Randall, Janice, Munn, David H., Mellor, Andrew L.

“… Increased pain sensitivity is a comorbidity associated with many clinical diseases, though the underlying causes are poorly understood. Recently, chronic pain …”
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The TIGIT+ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation von de Lima, Mikhael Haruo Fernandes, Machado, Caio Cavalcante, Nascimento, Daniele Carvalho, Silva, Camila Meirelles S., Toller-Kawahisa, Juliana Escher, Rodrigues, Tamara Silva, Veras, Flavio Protassio, Pontelli, Marjorie Cornejo, Castro, Italo A., Zamboni, Dario Simões, Filho, José-Carlos A., Cunha, Thiago M., Arruda, Eurico, da Cunha, Larissa Dias, Oliveira, Renê D. R., Cunha, Fernando Q., Louzada-Junior, Paulo

“… The TIGIT + FOXP3 + Treg subset (TIGIT + Tregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic …”
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