Suchergebnisse - "Croucher, David R."

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients von Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R

“… Signaling pathways control cell fate decisions that ultimately determine the behavior of cancer cells. Therefore, the dynamics of pathway activity may contain …”
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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L, Bedo, Justin, McCabe, Mark J, Pajic, Marina, Croucher, David R, Rajal, Alvaro Gonzalez, Junankar, Simon R, Saunders, Darren N, Lobachevsky, Pavel, Papenfuss, Anthony T, Nessem, Danielle, Nobis, Max, Warren, Sean C, Timpson, Paul, Cowley, Mark, Vargas, Ana C, Qiu, Min R, Generali, Daniele G, Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M, Long, Georgina V, Blay, Jean-Yves, Thomas, David M

“… In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes …”
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Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades von Fey, Dirk, Croucher, David R., Kolch, Walter, Kholodenko, Boris N.

“… Mitogen-activated protein kinase (MAPK) cascades control cell fate decisions, such as proliferation, differentiation, and apoptosis by integrating and …”
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Revisiting the biological roles of PAI2 (SERPINB2) in cancer von Croucher, David R., Saunders, Darren N., Lobov, Sergei, Ranson, Marie

“… Tumour expression of the urokinase plasminogen activator correlates with invasive capacity. Consequently, inhibition of this serine protease by physiological …”
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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer von Yang, Xue, Ma, Xiuquan, Zhao, Tianyue, Croucher, David R., Nguyen, Elizabeth V., Clark, Kimberley C., Hu, Changyuan, Latham, Sharissa L., Bayly-Jones, Charles, Nguyen, Bao V., Budnar, Srikanth, Shin, Sung-Young, Nguyen, Lan K., Cotton, Thomas R., Chüeh, Anderly C., Lim Kam Sian, Terry C. C., Stratton, Margaret M., Ellisdon, Andrew M., Daly, Roger J.

“… The PEAK family of pseudokinases, comprising PEAK1-3, play oncogenic roles in several poor prognosis human cancers, including triple negative breast cancer …”
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Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers von Croucher, David R, Iconomou, Mary, Hastings, Jordan F, Kennedy, Sean P, Han, Jeremy Z R, Shearer, Robert F, McKenna, Jessie, Wan, Adrian, Lau, Joseph, Aparicio, Samuel, Saunders, Darren N

“… The dynamic assembly of multiprotein complexes is a central mechanism of many cell signaling pathways. This process is key to maintaining the spatiotemporal …”
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Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases von Trevelyan, Sarah J, Brewster, Jodi L, Burgess, Abigail E, Crowther, Jennifer M, Cadell, Antonia L, Parker, Benjamin L, Croucher, David R, Dobson, Renwick C J, Murphy, James M, Mace, Peter D

“… Apoptosis signal-regulating kinases (ASK1, ASK2, and ASK3) are activators of the p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) …”
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Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells von Hochgräfe, Falko, Zhang, Luxi, O'Toole, Sandra A, Browne, Brigid C, Pinese, Mark, Porta Cubas, Ana, Lehrbach, Gillian M, Croucher, David R, Rickwood, Danny, Boulghourjian, Alice, Shearer, Robert, Nair, Radhika, Swarbrick, Alexander, Faratian, Dana, Mullen, Peter, Harrison, David J, Biankin, Andrew V, Sutherland, Robert L, Raftery, Mark J, Daly, Roger J

“… To identify therapeutic targets and prognostic markers for basal breast cancers, breast cancer cell lines were subjected to mass spectrometry-based profiling …”
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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer von Kennedy, Sean P., Han, Jeremy Z. R., Portman, Neil, Nobis, Max, Hastings, Jordan F., Murphy, Kendelle J., Latham, Sharissa L., Cadell, Antonia L., Miladinovic, Dushan, Marriott, Gabriella R., O’Donnell, Yolande E. I., Shearer, Robert F., Williams, James T., Munoz, Amaya Garcia, Cox, Thomas R., Watkins, D. Neil, Saunders, Darren N., Timpson, Paul, Lim, Elgene, Kolch, Walter, Croucher, David R.

“… Background The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it …”
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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer von Alexandrou, Sarah, Lee, Christine S., Fernandez, Kristine J., Wiharja, Celine E., Eshraghi, Leila, Reeves, John, Reed, Daniel A., Portman, Neil, Phan, Zoe, Milioli, Heloisa H., Nikolic, Iva, Cadell, Antonia L., Croucher, David R., Simpson, Kaylene J., Lim, Elgene, Hickey, Theresa E., Millar, Ewan K. A., Alves, Carla L., Ditzel, Henrik J., Caldon, C. Elizabeth

“… CDK4/6 inhibitors in combination with endocrine therapy are now used as front-line treatment for patients with estrogen-receptor positive (ER+) breast cancer …”
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A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma von Gonzalez Rajal, Alvaro, Marzec, Kamila A, McCloy, Rachael A, Nobis, Max, Chin, Venessa, Hastings, Jordan F, Lai, Kaitao, Kennerson, Marina, Hughes, William E, Vaghjiani, Vijesh, Timpson, Paul, Cain, Jason E, Watkins, D Neil, Croucher, David R, Burgess, Andrew

“… We previously used a pulse-based in vitro assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma …”
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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages von Munoz, Marcia A, Fletcher, Emma K, Skinner, Oliver P, Jurczyluk, Julie, Kristianto, Esther, Hodson, Mark P, Sun, Shuting, Ebetino, Frank H, Croucher, David R, Hansbro, Philip M, Center, Jacqueline R, Rogers, Michael J

“… Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by …”
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Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway von Croucher, David R, Hochgräfe, Falko, Zhang, Luxi, Liu, Ling, Lyons, Ruth J, Rickwood, Danny, Tactacan, Carole M, Browne, Brigid C, Ali, Naveid, Chan, Howard, Shearer, Robert, Gallego-Ortega, David, Saunders, Darren N, Swarbrick, Alexander, Daly, Roger J

“… Basal breast cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pathogenicity of this disease. In this study, we …”
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Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma von Phimmachanh, Monica, Han, Jeremy Z. R., O’Donnell, Yolande E. I., Latham, Sharissa L., Croucher, David R.

“… Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone …”
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The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family von Kennedy, Sean P., Hastings, Jordan F., Han, Jeremy Z. R., Croucher, David R.

“… Each member of the epidermal growth factor receptor (EGFR) family plays a key role in normal development, homeostasis, and a variety of pathophysiological …”
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A zebrafish functional genomics model to investigate the role of human A20 variants in vivo von Cultrone, Daniele, Zammit, Nathan W., Self, Eleanor, Postert, Benno, Han, Jeremy Z. R., Bailey, Jacqueline, Warren, Joanna, Croucher, David R., Kikuchi, Kazu, Bogdanovic, Ozren, Chtanova, Tatyana, Hesselson, Daniel, Grey, Shane T.

“… Germline loss-of-function variation in TNFAIP3 , encoding A20, has been implicated in a wide variety of autoinflammatory and autoimmune conditions, with …”
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Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover von Raftopulos, Nikki L., Washaya, Tinashe C., Niederprüm, Andreas, Egert, Antonia, Hakeem-Sanni, Mariam F., Varney, Bianca, Aishah, Atqiya, Georgieva, Mariya L., Olsson, Ellinor, dos Santos, Diandra Z., Nassar, Zeyad D., Cochran, Blake J., Nagarajan, Shilpa R., Kakani, Meghna S., Hastings, Jordan F., Croucher, David R., Rye, Kerry-Anne, Butler, Lisa M., Grewal, Thomas, Hoy, Andrew J.

“… Background Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens …”
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t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions von Freeman, Roxann, Niego, Be׳eri, R. Croucher, David, Pedersen, Lars O., Medcalf, Robert L.

“… Tissue-type plasminogen activator (t-PA) is the only thrombolytic treatment available for patients with acute ischaemic stroke. However, t-PA can increase …”
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Nedd4 controls animal growth by regulating IGF-1 signaling von Cao, Xiao R, Lill, Nancy L, Boase, Natasha, Shi, Peijun P, Croucher, David R, Shan, Hongbo, Qu, Jing, Sweezer, Eileen M, Place, Trenton, Kirby, Patricia A, Daly, Roger J, Kumar, Sharad, Yang, Baoli

“… The ubiquitin ligase Nedd4 has been proposed to regulate a number of signaling pathways, but its physiological role in mammals has not been characterized. Here …”
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Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma von Hastings, Jordan F, Gonzalez Rajal, Alvaro, Latham, Sharissa L, Han, Jeremy ZR, McCloy, Rachael A, O'Donnell, Yolande EI, Phimmachanh, Monica, Murphy, Alexander D, Nagrial, Adnan, Daneshvar, Dariush, Chin, Venessa, Watkins, D Neil, Burgess, Andrew, Croucher, David R

“… The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by …”
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