Suchergebnisse - "Cronin, Nora B"

Cryo-EM structure of the Smc5/6 holo-complex von Hallett, Stephen T, Campbell Harry, Isabella, Schellenberger, Pascale, Zhou, Lihong, Cronin, Nora B, Baxter, Jonathan, Etheridge, Thomas J, Murray, Johanne M, Oliver, Antony W

“… Abstract The Smc5/6 complex plays an essential role in the resolution of recombination intermediates formed during mitosis or meiosis, or as a result of the …”
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The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin von Winterhalter, Charles, Pelliciari, Simone, Stevens, Daniel, Fenyk, Stepan, Marchand, Elie, Cronin, Nora B, Soultanas, Panos, Costa, Tiago R D, Ilangovan, Aravindan, Murray, Heath

“… Abstract Genome replication is a fundamental biological activity shared by all organisms. Chromosomal replication proceeds bidirectionally from origins, …”
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Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome von Faull, Sarah V., Lau, Andy M. C., Martens, Chloe, Ahdash, Zainab, Hansen, Kjetil, Yebenes, Hugo, Schmidt, Carla, Beuron, Fabienne, Cronin, Nora B., Morris, Edward P., Politis, Argyris

“… Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by …”
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A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases von Southall, Stacey M., Cronin, Nora B., Wilson, Jon R.

“… The delivery of site-specific post-translational modifications to histones generates an epigenetic regulatory network that directs fundamental DNA-mediated …”
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Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures von Barski, Michal S., Vanzo, Teresa, Zhao, Xue Zhi, Smith, Steven J., Ballandras-Colas, Allison, Cronin, Nora B., Pye, Valerie E., Hughes, Stephen H., Burke, Terrence R., Cherepanov, Peter, Maertens, Goedele N.

“… Between 10 and 20 million people worldwide are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). Despite causing life-threatening pathologies …”
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Publisher Correction: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures von Barski, Michal S., Vanzo, Teresa, Zhao, Xue Zhi, Smith, Steven J., Ballandras-Colas, Allison, Cronin, Nora B., Pye, Valerie E., Hughes, Stephen H., Burke, Terrence R., Cherepanov, Peter, Maertens, Goedele N.

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TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry von Baggen, Jim, Jacquemyn, Maarten, Persoons, Leentje, Vanstreels, Els, Pye, Valerie E, Wrobel, Antoni G, Calvaresi, Valeria, Martin, Stephen R, Roustan, Chloë, Cronin, Nora B, Reading, Eamonn, Thibaut, Hendrik Jan, Vercruysse, Thomas, Maes, Piet, De Smet, Frederik, Yee, Angie, Nivitchanyong, Toey, Roell, Marina, Franco-Hernandez, Natalia, Rhinn, Herve, Mamchak, Alusha Andre, Ah Young-Chapon, Maxime, Brown, Eric, Cherepanov, Peter, Daelemans, Dirk

“… SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by the availability of entry receptors on host cells. Here, we show that …”
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A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination von Seow, Jeffrey, Khan, Hataf, Rosa, Annachiara, Calvaresi, Valeria, Graham, Carl, Pickering, Suzanne, Pye, Valerie E., Cronin, Nora B., Huettner, Isabella, Malim, Michael H., Politis, Argyris, Cherepanov, Peter, Doores, Katie J.

“… Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the target for neutralizing antibodies elicited following both infection and vaccination …”
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Structural basis for translocation by AddAB helicase–nuclease and its arrest at χ sites von Krajewski, Wojciech W., Fu, Xin, Wilkinson, Martin, Cronin, Nora B., Dillingham, Mark S., Wigley, Dale B.

“… A dual-function helicase–nuclease, typified by RecBCD in Escherichia coli , acts on free DNA ends during bacterial double-stranded break repair until it …”
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Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain von Cronin, Nora B., Yang, Jing, Zhang, Ziguo, Kulkarni, Kiran, Chang, Leifu, Yamano, Hiroyuki, Barford, David

“… Many essential biological processes are mediated by complex molecular machines comprising multiple subunits. Knowledge on the architecture of individual …”
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Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation von Cronin, Nora B, O'Reilly, Andrias, Duclohier, Hervé, Wallace, B A

“… Voltage-gated sodium channels are dynamic membrane proteins characterized by rapid conformational changes that switch the molecule between closed resting, …”
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Synthesis of a Ribose-Incorporating Medium Ring Scaffold via a Challenging Ring-Closing Metathesis Reaction von Rankin, Stuart S., Caldwell, John J., Cronin, Nora B., van Montfort, Rob L. M., Collins, Ian

“… A practical synthesis of a novel oxabicyclo[6.2.1]undecenetriol useful as a medicinal chemistry scaffold has been developed starting from l‐ribose. The …”
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TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network von Jones, Taylor, Feng, Junjie, Luyties, Olivia, Cozzolino, Kira, Sanford, Lynn, Rimel, Jenna K., Ebmeier, Christopher C., Shelby, Grace S., Watts, Lotte P., Rodino, Jessica, Rajagopal, Nisha, Hu, Shanhu, Brennan, Finn, Maas, Zachary L., Alnemy, Sydney, Richter, William F., Koh, Adrian F., Cronin, Nora B., Madduri, Ameya, Das, Jhuma, Cooper, Elliot, Hamman, Kristin B., Chuaqui, Claudio, Carulli, John P., Allen, Mary A., Spencer, Sabrina, Kotecha, Abhay, Marineau, Jason J., Greber, Basil J., Dowell, Robin D., Taatjes, Dylan J.

“… How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution …”
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Tetrameric bacterial sodium channels: characterization of structure, stability, and drug binding von Nurani, Ghasem, Radford, Matthew, Charalambous, Kalypso, O'Reilly, Andrias O, Cronin, Nora B, Haque, Sharmeen, Wallace, B A

“… NaChBac from Bacillus halodurans is a bacterial homologue of mammalian voltage-gated sodium channels. It has been proposed that a NaChBac monomer corresponds …”
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Effects of deglycosylation of sodium channels on their structure and function von Cronin, Nora B, O'Reilly, Andrias, Duclohier, Hervé, Wallace, B A

“… Voltage-gated sodium channels are important membrane proteins underlying electrical signaling in the nervous and muscular systems. They undergo rapid …”
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Higher-order cryo-EM structures of the full tetrameric type II topoisomerase with bound 18mer dsDNA von Najmudin, Shabir, Pan, Xiao-Su, Beavil, Andrew J., Cronin, Nora B., Ilangovan, Aravindan, Fisher, L. Mark, Sanderson, Mark R.

“… Abstract only …”
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Cryo-EM structure of the Smc5/6 holo-complex von Hallett, Stephen T, Campbell, Isabella, Schellenberger, Pascale, Zhou, Lihong, Cronin, Nora B, Baxter, Jonathan, Etheridge, Thomas J, Murray, Johanne M, Oliver, Antony W

“… The Smc5/6 complex plays an essential role in the resolution of recombination intermediates formed during mitosis or meiosis, or as a result of the cellular …”
Volltext

Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome von Faull, Sarah V, Lau, Andy, Martens, Chloe, Ahdash, Zainab, Yebenes, Hugo, Schmidt, Carla, Beuron, Fabienne, Cronin, Nora B, Morris, Edward P, Politis, Argyris

“… Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by …”
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Structural basis for translocation by AddAB helicase-nuclease and its arrest at [chi] sites von Krajewski, Wojciech W, Fu, Xin, Wilkinson, Martin, Cronin, Nora B, Dillingham, Mark S, Wigley, Dale B

“… A dual-function helicase-nuclease, typified by RecBCD in Escherichia coli, acts on free DNA ends during bacterial double-stranded break repair until it reaches …”
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Positive and negative control of helicase recruitment at a bacterial chromosome origin von Winterhalter, Charles, Stevens, Daniel, Fenyk, Stepan, Pelliciari, Simone, Marchand, Elie, Cronin, Nora B, Soultanas, Panos, Costa, Tiago, Ilangovan, Aravindan, Heath, Murray

“… The mechanisms responsible for helicase loading during the initiation of chromosome replication in bacteria are unclear. Here we report both a positive and a …”
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