Výsledky vyhľadávania - "Cox, Michael C."

Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors Autor Davis, Jessica L, Lockwood, Christina M, Stohr, Bradley, Boecking, Carolin, Al-Ibraheemi, Alyaa, DuBois, Steven G, Vargas, Sara O, Black, Jennifer O, Cox, Michael C, Luquette, Mark, Turpin, Brian, Szabo, Sara, Laetsch, Theodore W, Albert, Catherine M, Parham, David M, Hawkins, Douglas S, Rudzinski, Erin R

“…Pediatric mesenchymal tumors harboring variant NTRK fusions (ETV6-negative) are being increasingly described; however, the histologic and clinical features of…”
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Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long‐Term Survival Autor Mankowski, Robert T., Anton, Stephen D., Ghita, Gabriela L., Brumback, Babette, Cox, Michael C., Mohr, Alicia M., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Efron, Philip A., Brakenridge, Scott C., Moore, Frederick A.

“…Objectives Sepsis has been called a “disease of the elderly,” and as in‐hospital mortality has decreased, more sepsis survivors are progressing into poorly…”
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Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma Autor Ziegler, David S, Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J, Lau, Loretta M S, Reynolds, Mark, Cox, Michael C, Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J, Ekert, Paul G, Marshall, Glenn M, Haber, Michelle

“…Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK…”
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Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis Autor Hollen, McKenzie K., Stortz, Julie A., Darden, Dijoia, Dirain, Marvin L., Nacionales, Dina C., Hawkins, Russell B., Cox, Michael C., Lopez, Maria-Cecilia, Rincon, Jaimar C., Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L., Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A., Baker, Henry V., Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A.

“…Background Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the…”
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Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study Autor Stortz, Julie A., Cox, Michael C., Hawkins, Russell B., Ghita, Gabriela L., Brumback, Babette A., Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A., Brakenridge, Scott C., Moore, Frederick A.

“…Background The role of site of infection in sepsis has been poorly characterized. Additionally, sepsis epidemiology has evolved. Early mortality has decreased,…”
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The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis Autor Cox, Michael C., Booth, Matthew, Ghita, Gabriela, Wang, Zhongkai, Gardner, Anna, Hawkins, Russell B., Darden, Dijoia B., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Moore, Frederick A., Efron, Philip A., Anton, Steven, Brakenridge, Scott C.

“…Background Sarcopenia is a known risk factor for poor outcomes across many chronic diseases. The impact on outcomes of both pre‐existing sarcopenia and acute…”
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Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice Autor Mankowski, Robert T, Thomas, Ryan M, Darden, Dijoia B, Gharaibeh, Raad Z, Hawkins, Russell B, Cox, Michael C, Apple, Camille, Nacionales, Dina C, Ungaro, Ricardo F, Dirain, Marvin L, Moore, Fredrick A, Leeuwenburgh, Christiaan, Brakenridge, Scott C, Clanton, Thomas L, Laitano, Orlando, Moldawer, Lyle L, Mohr, Alicia M, Efron, Philip A

“…Older adults have worse outcomes after sepsis than young adults. Additionally, alterations of the gut microbiota have been demonstrated to contribute to…”
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Herbal remedies in the United States: potential adverse interactions with anticancer agents Autor Sparreboom, Alex, Cox, Michael C, Acharya, Milin R, Figg, William D

“…Interest in the use of herbal products has grown dramatically in the Western world. Recent estimates suggest an overall prevalence for herbal preparation use…”
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Larotrectinib in TRK fusion–positive pediatric B-cell acute lymphoblastic leukemia Autor Schewe, Denis M., Lenk, Lennart, Vogiatzi, Fotini, Winterberg, Dorothee, Rademacher, Annika V., Buchmann, Swantje, Henry, Dahlia, Bergmann, Anke K., Cario, Gunnar, Cox, Michael C.

“…•Larotrectinib can be effective in patients with ETV6-NTRK3–positive B-cell lymphoblastic leukemia, inducing prolonged molecular remission.•Single-agent…”
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Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults Autor Darden, Dijoia B., Stortz, Julie A., Hollen, McKenzie K., Cox, Michael C., Apple, Camille G., Hawkins, Russell B., Rincon, Jaimar C., Lopez, Maria-Cecilia, Wang, Zhongkai, Navarro, Eduardo, Hagen, Jennifer E., Parvataneni, Hari K., Brusko, Maigan A., Kladde, Michael, Bacher, Rhonda, Brumback, Babette A., Brakenridge, Scott C., Baker, Henry V., Cogle, Christopher R., Mohr, Alicia M., Efron, Philip A.

“…Older adults have significantly worse morbidity and mortality after severe trauma than younger cohorts. The competency of the innate immune response decreases…”
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Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study Autor Laetsch, Theodore W, DuBois, Steven G, Mascarenhas, Leo, Turpin, Brian, Federman, Noah, Albert, Catherine M, Nagasubramanian, Ramamoorthy, Davis, Jessica L, Rudzinski, Erin, Feraco, Angela M, Tuch, Brian B, Ebata, Kevin T, Reynolds, Mark, Smith, Steven, Cruickshank, Scott, Cox, Michael C, Pappo, Alberto S, Hawkins, Douglas S

“…Gene fusions involving NTRK1, NTRK2, or NTRK3 (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective…”
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Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101 Autor Nagasubramanian, Ramamoorthy, Wei, Julie, Gordon, Paul, Rastatter, Jeff C., Cox, Michael C., Pappo, Alberto

“…Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and…”
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Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel Autor Cox, Michael C, Low, Jennifer, Lee, James, Walshe, Janice, Denduluri, Neelima, Berman, Arlene, Permenter, Matthew G, Petros, William P, Price, Douglas K, Figg, William D, Sparreboom, Alex, Swain, Sandra M

“…The herbal supplement garlic (Allium sativum) is commonly used by cancer patients. Preclinical studies have shown that allicin, a major component of garlic,…”
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The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas Autor DuBois, Steven G., Laetsch, Theodore W., Federman, Noah, Turpin, Brian K., Albert, Catherine M., Nagasubramanian, Ramamoorthy, Anderson, Megan E., Davis, Jessica L., Qamoos, Hope E., Reynolds, Mark E., Cruickshank, Scott, Cox, Michael C., Hawkins, Douglas S., Mascarenhas, Leo, Pappo, Alberto S.

“…Background The highly selective oral tropomyosin receptor kinase (TRK) inhibitor larotrectinib has demonstrated significant activity in adult and pediatric TRK…”
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Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes Autor Brakenridge, Scott C, Efron, Philip A, Cox, Michael C, Stortz, Julie A, Hawkins, Russell B, Ghita, Gabriela, Gardner, Anna, Mohr, Alicia M, Anton, Stephen D, Moldawer, Lyle L, Moore, Frederick A

“…We sought to compare traditional inpatient outcomes to long-term functional outcomes and mortality of surgical intensive care unit (SICU) patients with sepsis…”
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Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes Autor Cox, Michael C., Brakenridge, Scott C., Stortz, Julie A., Hawkins, Russell B., Darden, Dijoa B., Ghita, Gabriela L., Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A., Moore, Frederick A.

“…As hospital sepsis mortality has decreased, more surgical ICU survivors are progressing into chronic critical illness (CCI). This study documents the incidence…”
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Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma Autor Halalsheh, Hadeel, McCarville, Mary Beth, Neel, Michael, Reynolds, Mark, Cox, Michael C., Pappo, Alberto S.

“…Mesoblastic nephroma is the most frequent renal tumor in newborns and young infants, and the cellular type is characterized by an ETV6–NTRK fusion, which…”
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Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients Autor Polcz, Valerie E., Barrios, Evan L., Cox, Michael C., Rocha, Ivanna, Liang, Muxuan, Hawkins, Russell B., Darden, Dijoia, Ungaro, Ricardo, Dirain, Marvin, Mankowski, Robert, Mohr, Alicia M., Moore, Frederick A., Moldawer, Lyle L., Efron, Philip A., Brakenridge, Scott C., Loftus, Tyler J.

“…Sarcopenia is a known risk factor for adverse outcomes across multiple disease states, including severe trauma. Factors such as age, hyperinflammation,…”
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Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study Autor Darden, Dijoia B, Bacher, Rhonda, Brusko, Maigan A, Knight, Parker, Hawkins, Russell B, Cox, Michael C, Dirain, Marvin L, Ungaro, Ricardo, Nacionales, Dina C, Rincon, Jaimar C, Gauthier, Marie-Pierre L, Kladde, Michael, Bihorac, Azra, Brusko, Todd M, Moore, Frederick A, Brakenridge, Scott C, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

“…Increased circulating myeloid-derived suppressor cells (MDSCs) are independently associated with poor long-term clinical outcomes in sepsis. Studies implicate…”
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Paediatric strategy forum for medicinal product development of cyclin-dependent kinase inhibitors in children and adolescents ACCELERATE in collaboration with the European Medicines Agency With participation of the Food and Drug Administration Autor Pearson, Andrew DJ, Chi, Susan, Laetscht, Theodore W., Marshall, Lynley, Raetz, Elizabeth, George, Rani E., Chesler, Louis, Karres, Dominik, Scobie, Nicole, Knoderer, Holly, Weigel, Brenda, Teachey, David, Sonke, Gabe S., Seibel, Nita, Pappo, Alberto, Nysom, Karsten, Muscal, Jodi, Molenaar, Jan, McDonough, Joe, Macy, Margaret E., Ludwinski, Donna, Lin, Charles, Ligas, Franca, Lesa, Giovanni, Knox, Leona, Kirschbaum, Mark, Kieran, Mark, Kholmanskikh, Olga, Jacobson, Amanda, Heenen, Delphine, Hawkins, Douglas S., Glade Bender, Julia, Fox, Elizabeth, Demolis, Pierre, de Rojas, Teresa, Cox, Michael C., Chauvin, Benedicte, Blanc, Patricia, Vassal, Gilles

“…The twelfth multi-stakeholder Paediatric Strategy focused on cyclin-dependent kinase (CDK) inhibitors. Genetic aberrations in paediatric tumours increase…”
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