Výsledky vyhľadávania - "Cowan, Simone"

Cardiac Rehabilitation During the COVID-19 Era: Guidance on Implementing Virtual Care Autor Moulson, Nathaniel, Bewick, David, Selway, Tracy, Harris, Jennifer, Suskin, Neville, Oh, Paul, Coutinho, Thais, Singh, Gurmeet, Chow, Chi-Ming, Clarke, Brian, Cowan, Simone, Fordyce, Christopher B., Fournier, Anne, Gin, Kenneth, Gupta, Anil, Hardiman, Sean, Jackson, Simon, Lamarche, Yoan, Lau, Benny, Légaré, Jean-François, Leong-Poi, Howard, Mansour, Samer, Marelli, Ariane, Quraishi, Ata ur Rehman, Roifman, Idan, Ruel, Marc, Sapp, John, Small, Gary, Turgeon, Ricky, Wood, David A., Zieroth, Shelley, Virani, Sean, Krahn, Andrew D.

“…Cardiac rehabilitation programs across Canada have suspended in-person services as a result of large-scale physical distancing recommendations designed to…”
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Prescription Drug Coverage of Guideline-Directed Medical Therapy for People Living with Heart Failure with Reduced Ejection Fraction in Canada Autor Cowan, Simone S., Kosar, Lynette, Poon, Stephanie, Bains, Marc, Costigan, Jeannine, Ducharme, Anique, Gewarges, Mena, Groulx, Sharon, MacFarlane, Kendra, Nagpal, Seema, Singer, Alexander, McKelvie, Robert

“…Guideline-directed medical therapy (GDMT) for heart failure (HF) is cost-effective and is associated with significant reductions in morbidity and mortality…”
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Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors Autor Towers, Greg J, Hatziioannou, Theodora, Cowan, Simone, Goff, Stephen P, Luban, Jeremy, Bieniasz, Paul D

“…Many mammalian species express restriction factors that confer host resistance to retroviral infection. Here we show that HIV-1 sensitivity to restriction…”
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Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells Autor Hatziioannou, Theodora, Perez-Caballero, David, Cowan, Simone, Bieniasz, Paul D

“…Cyclophilin A (CypA) is a peptidyl-prolyl isomerase that binds to the capsid protein (CA) of human immunodeficiency virus type 1 (HIV-1) and by doing so…”
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Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity Autor Perez-Caballero, David, Hatziioannou, Theodora, Zhang, Fengwen, Cowan, Simone, Bieniasz, Paul D

“…TRIM-CypA is an owl monkey-specific variant of the retrovirus restriction factor TRIM5alpha. Here, we exploit its modular domain organization and cyclosporine…”
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Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism Autor Cowan, Simone, Hatziioannou, Theodora, Cunningham, Tshaka, Muesing, Mark A, Gottlinger, Heinrich G, Bieniasz, Paul D

“…Many nonhuman primate cells are unable to support the replication of HIV-1, whereas others are nonpermissive for infection by simian immunodeficiency virus…”
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Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid Autor Hatziioannou, Theodora, Cowan, Simone, Von Schwedler, Uta K, Sundquist, Wesley I, Bieniasz, Paul D

“…Retroviral tropism is determined in part by cellular restriction factors that block infection by targeting the incoming viral capsid. Indeed, human…”
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A cost-effectiveness analysis of a proactive management strategy for the Sprint Fidelis recall: a probabilistic decision analysis model Autor Bashir, Jamil, Cowan, Simone, Raymakers, Adam, Yamashita, Michael, Danter, Matthew, Krahn, Andrew, Lynd, Larry D

“…The management of the recall is complicated by the competing risks of lead failure and complications that can occur with lead revision. Many of these patients…”
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Pim serine/threonine kinases regulate the stability of Socs-1 protein Autor Chen, X Peter, Losman, Julie A, Cowan, Simone, Donahue, Elizabeth, Fay, Scott, Vuong, Bao Q, Nawijn, Martijn C, Capece, Danielle, Cohan, Victoria L, Rothman, Paul

“…Studies of SOCS-1-deficient mice have implicated Socs-1 in the suppression of JAK-STAT (Janus tyrosine kinase-signal transducers and activators of…”
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Capsid-dependent and -independent postentry restriction of primate lentivirus tropism in rodent cells Autor Hatziioannou, Theodora, Cowan, Simone, Bieniasz, Paul D

“…Retrovirus tropism can be restricted by cellular factors such as Fv1, Ref1, and Lv1 that inhibit infection by targeting the incoming viral capsid. Here, we…”
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A Population‐Based Evaluation of a Regional Asthma Education Centre Autor Cowan, Simone, Ernst, Pierre, Cartier, André, Boulet, Louis-Philippe

“…BACKGROUND: A population‐based, ecological evaluation was conducted to determine the impact of a regional asthma education centre on reducing asthma‐related…”
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Long COVID-19: A Primer for Cardiovascular Health Professionals, on Behalf of the CCS Rapid Response Team Autor Paterson, Ian, Ramanathan, Krishnan, Aurora, Rakesh, Bewick, David, Chow, Chi-Ming, Clarke, Brian, Cowan, Simone, Ducharme, Anique, Gin, Kenneth, Graham, Michelle, Gupta, Anil, Jassal, Davinder S., Kazmi, Mustapha, Krahn, Andrew, Lamarche, Yoan, Marelli, Ariane, Roifman, Idan, Ruel, Marc, Singh, Gurmeet, Sterns, Larry, Turgeon, Ricky, Virani, Sean, Wong, Kenny K., Zieroth, Shelley

“…It is now widely recognized that COVID-19 illness can be associated with significant intermediate and potentially longer-term physical limitations. The term,…”
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Modified Polyethersulfone (PES) Ultrafiltration Membranes for Enhanced Filtration of Whey Proteins Autor Cowan, Simone, Ritchie, Stephen

“…Application of membrane technology to whey protein separation is an interesting development that has seen growth in recent years. In particular, modification…”
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Cardiovascular Care Delivery During the Second Wave of COVID-19 in Canada Autor Roifman, Idan, Arora, Rakesh C., Bewick, David, Chow, Chi-Ming, Clarke, Brian, Cowan, Simone, Ducharme, Anique, Gin, Kenneth, Graham, Michelle, Gupta, Anil, Hardiman, Sean, Hartleib, Michael, Jackson, Simon, Jassal, Davinder, Kazmi, Mustapha, Lamarche, Yoan, Légaré, Jean-François, Leong-Poi, Howard, Mansour, Samer, Marelli, Ariane, Ruel, Marc, Small, Gary, Sterns, Larry, Turgeon, Ricky, Virani, Sean, Wijeysundera, Harindra C., Wong, Kenny, Wood, David A., Zieroth, Shelley, Singh, Gurmeet, Krahn, Andrew D.

“…Hospitals and ambulatory facilities significantly reduced cardiac care delivery in response to the first wave of the COVID-19 pandemic. The deferral of…”
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Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence Autor Turgeon, Ricky D., Zieroth, Shelley, Bewick, David, Chow, Chi-Ming, Clarke, Brian, Cowan, Simone, Fordyce, Christopher B., Fournier, Anne, Gin, Kenneth, Gupta, Anil, Hardiman, Sean, Jackson, Simon, Lau, Benny, Leong-Poi, Howard, Mansour, Samer, Marelli, Ariane, Quraishi, Ata Rehman, Roifman, Idan, Ruel, Marc, Sapp, John, Singh, Gurmeet, Small, Gary, Virani, Sean, Wood, David A., Krahn, Andrew

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Guiding Cardiac Care During the COVID-19 Pandemic: How Ethics Shapes Our Health System Response Autor Virani, Alice, Singh, Gurmeet, Bewick, David, Chow, Chi-Ming, Clarke, Brian, Cowan, Simone, Fordyce, Christopher B., Fournier, Anne, Gin, Kenneth, Gupta, Anil, Hardiman, Sean, Jackson, Simon, Lamarche, Yoan, Lau, Benny, Légaré, Jean-François, Leong-Poi, Howard, Mansour, Samer, Marelli, Ariane, Quraishi, Ata, Roifman, Idan, Ruel, Marc, John Sapp, Small, Gary, Turgeon, Ricky, Wood, David A., Zieroth, Shelley, Virani, Sean, Krahn, Andrew D.

“…The COVID-19 pandemic has raised ethical questions for the cardiovascular leader and practitioner. Attention has been redirected from a system that focuses on…”
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Mineralocorticoid receptor antagonists and mortality in heart failure with concurrent atrial fibrillation Autor McCullough, Peter A, Cowan, Simone

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Restriction of multiple divergent retroviruses by Lv1 and Ref1 Autor Hatziioannou, Theodora, Cowan, Simone, Goff, Stephen P., Bieniasz, Paul D., Towers, Greg J.

“…The mouse gene Fv1 encodes a saturable restriction factor that selectively blocks infection by N‐tropic or B‐tropic murine leukemia virus (MLV) strains…”
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Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells Autor Tau, G Z, Cowan, S N, Weisburg, J, Braunstein, N S, Rothman, P B

“…Previous studies have demonstrated that, as naive murine CD4(+) cells differentiate into Th1 cells, they lose expression of the second chain of IFN-gammaR…”
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Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity Autor Perez-Caballero, David, Hatziioannou, Theodora, Yang, Annie, Cowan, Simone, Bieniasz, Paul D

“…The tripartite motif 5alpha protein (TRIM5alpha) is one of several factors expressed by mammalian cells that inhibit retrovirus replication. Human TRIM5alpha…”
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