Výsledky vyhľadávania - "Conner, Sarah C"

Comparison of Treatment Effects Measured by the Hazard Ratio and by the Ratio of Restricted Mean Survival Times in Oncology Randomized Controlled Trials Autor Trinquart, Ludovic, Jacot, Justine, Conner, Sarah C, Porcher, Raphaël

“…We aimed to compare empirically the treatment effects measured by the hazard ratio (HR) and by the difference (and ratio) of restricted mean survival times…”
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Clinical Burden and Healthcare Resource Utilization Associated With Managing Transfusion-dependent β-Thalassemia in England Autor Udeze, Chuka, Ly, Nelly F., Ingleby, Fiona C., Fleming, Sophia D., Conner, Sarah C., Howard, Jo, Li, Nanxin, Shah, Farrukh

“…•Endocrine complications are common in transfusion-dependent β-thalassemia.•Use of healthcare resources is high in transfusion-dependent β-thalassemia compared…”
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Clinical Burden and Health Care Resource Utilization Associated With Managing Sickle Cell Disease With Recurrent Vaso-occlusive Crises in England Autor Udeze, Chuka, Ly, Nelly F., Ingleby, Fiona C., Fleming, Sophia D., Conner, Sarah C., Howard, Jo, Li, Nanxin, Shah, Farrukh

“…•Sickle cell disease is associated with substantial clinical burden.•Mean age of death in patients with recurrent vaso-occlusive crises is 40.17…”
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Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study Autor McGrath, Emer R., Himali, Jayandra J., Levy, Daniel, Conner, Sarah C., Pase, Matthew P., Abraham, Carmela R., Courchesne, Paul, Satizabal, Claudia L., Vasan, Ramachandran S., Beiser, Alexa S., Seshadri, Sudha

“…Fibroblast growth factor 23 is an emerging vascular biomarker, recently associated with cerebral small vessel disease and poor cognition in patients on…”
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Growth Differentiation Factor 15 and NT‐proBNP as Blood‐Based Markers of Vascular Brain Injury and Dementia Autor McGrath, Emer R., Himali, Jayandra J., Levy, Daniel, Conner, Sarah C., DeCarli, Charles, Pase, Matthew P., Ninomiya, Toshiharu, Ohara, Tomoyuki, Courchesne, Paul, Satizabal, Claudia L., Vasan, Ramachandran S., Beiser, Alexa S., Seshadri, Sudha

“…Background GDF15 (growth differentiation factor 15) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) may offer promise as biomarkers for cognitive…”
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Insulin-Like Growth Factor, Inflammation, and MRI Markers of Alzheimer's Disease in Predominantly Middle-Aged Adults Autor Wittfeld, Katharina, Raman, Mekala R, Conner, Sarah C, Aslam, Asra, Teumer, Alexander, Nauck, Matthias, Hosten, Norbert, Habes, Mohamad, DeCarli, Charles, Vasan, Ramachandran S, Beiser, Alexa S, Himali, Jayandra J, Seshadri, Sudha, Grabe, Hans J, Satizabal, Claudia L

“…Insulin-like growth factor 1 (IGF-1) signaling has been implicated in Alzheimer's disease pathogenesis, and further evidence suggests inflammation can be a…”
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Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults Autor Raman, Mekala R, Himali, Jayandra J, Conner, Sarah C, DeCarli, Charles, Vasan, Ramachandran S, Beiser, Alexa S, Seshadri, Sudha, Maillard, Pauline, Satizabal, Claudia L

“…Background and Purpose- Little is known about associations between vascular growth factors and magnetic resonance imaging (MRI) markers in midlife. We…”
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Circulating IGFBP‐2: a novel biomarker for incident dementia Autor McGrath, Emer R., Himali, Jayandra J., Levy, Daniel, Conner, Sarah C., DeCarli, Charles S., Pase, Matthew P., Courchesne, Paul, Satizabal, Claudia L., Vasan, Ramachandran S., Beiser, Alexa S., Seshadri, Sudha

“…Objective To determine the association between plasma insulin‐like growth factor binding protein 2 (IGFBP‐2) and cognitive outcomes. Methods We measured plasma…”
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Estimation and modeling of the restricted mean time lost in the presence of competing risks Autor Conner, Sarah C., Trinquart, Ludovic

“…Survival data with competing or semi‐competing risks are common in observational studies. As an alternative to cause‐specific and subdistribution hazard…”
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Refining the Association Between Body Mass Index and Atrial Fibrillation: G‐Formula and Restricted Mean Survival Times Autor Conner, Sarah C., Lodi, Sara, Lunetta, Kathryn L., Casas, Juan P., Lubitz, Steven A., Ellinor, Patrick T., Anderson, Christopher D., Huang, Qiuxi, Coleman, Justin, White, Wendy B., Benjamin, Emelia J., Trinquart, Ludovic

“…Background Previous studies assessing the association between body mass index (BMI) and atrial fibrillation (AF) did not account for time-varying covariates,…”
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Mid‐life and late‐life vascular risk factor burden and neuropathology in old age Autor Conner, Sarah C., Pase, Matthew P., Carneiro, Herman, Raman, Mekala R., McKee, Ann C., Alvarez, Victor E., Walker, Jamie M., Satizabal, Claudia L., Himali, Jayandra J., Stein, Thor D., Beiser, Alexa, Seshadri, Sudha

“…Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a…”
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Adjusted restricted mean survival times in observational studies Autor Conner, Sarah C., Sullivan, Lisa M., Benjamin, Emelia J., LaValley, Michael P., Galea, Sandro, Trinquart, Ludovic

“…In observational studies with censored data, exposure‐outcome associations are commonly measured with adjusted hazard ratios from multivariable Cox…”
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Marginal versus conditional rate estimation for count and recurrent event data with an estimand framework Autor Conner, Sarah C., Zhou, Yijie, Xu, Tu

“…Count and recurrent event endpoints are common key efficacy endpoints in clinical research. For example, in clinical research of pulmonary diseases such as…”
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Correction: Adjusted restricted mean survival times in observational studies Autor Conner, Sarah C., Trinquart, Ludovic

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Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study Autor Echouffo-Tcheugui, Justin B, Conner, Sarah C, Himali, Jayandra J, Maillard, Pauline, DeCarli, Charles S, Beiser, Alexa S, Vasan, Ramachandran S, Seshadri, Sudha

“…To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged…”
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Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community Autor Satizabal, Claudia L, Himali, Jayandra Jung, Conner, Sarah C, Beiser, Alexa S, Maillard, Pauline, Vasan, Ramachandran S, DeCarli, Charles, Seshadri, Sudha

“…Midlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this…”
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A comparison of statistical methods to predict the residual lifetime risk Autor Conner, Sarah C., Beiser, Alexa, Benjamin, Emelia J., LaValley, Michael P., Larson, Martin G., Trinquart, Ludovic

“…Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the…”
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Survivorship Bias in Analyses of Immune Checkpoint Inhibitor Trials Autor Conner, Sarah C, Trinquart, Ludovic

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Reply to K.H. Eng et al Autor Trinquart, Ludovic, Jacot, Justine, Conner, Sarah C, Porcher, Raphael

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Author response: Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study Autor Echouffo-Tcheugui, Justin, Conner, Sarah C, Himali, Jayandra J, Beiser, Alexa S, Seshadri, Sudha

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