Výsledky vyhledávání - "Computational and structural biotechnology journal"

Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer Autor Győrffy, Balázs

“…[Display omitted] Extensive research is directed to uncover new biomarkers capable to stratify breast cancer patients into clinically relevant cohorts…”
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UCell: Robust and scalable single-cell gene signature scoring Autor Andreatta, Massimo, Carmona, Santiago J.

“…UCell is an R package for evaluating gene signatures in single-cell datasets. UCell signature scores, based on the Mann-Whitney U statistic, are robust to…”
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Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model Autor Beck, Bo Ram, Shin, Bonggun, Choi, Yoonjung, Park, Sungsoo, Kang, Keunsoo

“…•The MT-DTI deep learning model was used to identify potent drugs for SARS-CoV-2.•Atazanavir, remdesivir, and Kaletra were predicted to inhibit…”
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The DisGeNET cytoscape app: Exploring and visualizing disease genomics data Autor Piñero, Janet, Saüch, Josep, Sanz, Ferran, Furlong, Laura I.

“…Thanks to the unbiased exploration of genomic variants at large scale, hundreds of thousands of disease-associated loci have been uncovered. In parallel,…”
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Integration strategies of multi-omics data for machine learning analysis Autor Picard, Milan, Scott-Boyer, Marie-Pier, Bodein, Antoine, Périn, Olivier, Droit, Arnaud

“…Schematic representation of the main strategies for multi-omics datasets integration. A) Early integration concatenates all omics datasets into a single matrix…”
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From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways Autor Wang, Yaqiu, Kanneganti, Thirumala-Devi

“…[Display omitted] Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed cell death (PCD) pathways, and they are intricately…”
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The oralome and its dysbiosis: New insights into oral microbiome-host interactions Autor Radaic, Allan, Kapila, Yvonne L.

“…[Display omitted] The oralome is the summary of the dynamic interactions orchestrated between the ecological community of oral microorganisms (comprised of up…”
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Statistical methods for Mendelian randomization in genome-wide association studies: A review Autor Boehm, Frederick J., Zhou, Xiang

“…[Display omitted] Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The…”
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The language of proteins: NLP, machine learning & protein sequences Autor Ofer, Dan, Brandes, Nadav, Linial, Michal

“…Natural language processing (NLP) is a field of computer science concerned with automated text and language analysis. In recent years, following a series of…”
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Review on circular RNAs and new insights into their roles in cancer Autor Tang, Xiaozhu, Ren, Hongyan, Guo, Mengjie, Qian, Jinjun, Yang, Ye, Gu, Chunyan

“…[Display omitted] Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by…”
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Machine Learning Methods for Histopathological Image Analysis Autor Komura, Daisuke, Ishikawa, Shumpei

“…Abundant accumulation of digital histopathological images has led to the increased demand for their analysis, such as computer-aided diagnosis using machine…”
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Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis Autor Menyhárt, Otília, Győrffy, Balázs

“…•Single-level data analysis produced by high-throughput technologies is limited by showing only a narrow window of cellular functions.•Data integration across…”
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A review on machine learning approaches and trends in drug discovery Autor Carracedo-Reboredo, Paula, Liñares-Blanco, Jose, Rodríguez-Fernández, Nereida, Cedrón, Francisco, Novoa, Francisco J., Carballal, Adrian, Maojo, Victor, Pazos, Alejandro, Fernandez-Lozano, Carlos

“…[Display omitted] •Machine Learning in drug discovery has greatly benefited the pharmaceutical industry.•Application of machine algorithms must entail a robust…”
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Application of PD-1 Blockade in Cancer Immunotherapy Autor Wu, Xiaomo, Gu, Zhongkai, Chen, Yang, Chen, Borui, Chen, Wei, Weng, Liqiang, Liu, Xiaolong

“…The programmed cell death protein 1 (PD-1) pathway has received considerable attention due to its role in eliciting the immune checkpoint response of T cells,…”
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Machine Learning and Data Mining Methods in Diabetes Research Autor Kavakiotis, Ioannis, Tsave, Olga, Salifoglou, Athanasios, Maglaveras, Nicos, Vlahavas, Ioannis, Chouvarda, Ioanna

“…The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical…”
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Network analysis methods for studying microbial communities: A mini review Autor Matchado, Monica Steffi, Lauber, Michael, Reitmeier, Sandra, Kacprowski, Tim, Baumbach, Jan, Haller, Dirk, List, Markus

“…Microorganisms including bacteria, fungi, viruses, protists and archaea live as communities in complex and contiguous environments. They engage in numerous…”
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Prediction of HER2-positive breast cancer recurrence and metastasis risk from histopathological images and clinical information via multimodal deep learning Autor Yang, Jialiang, Ju, Jie, Guo, Lei, Ji, Binbin, Shi, Shufang, Yang, Zixuan, Gao, Songlin, Yuan, Xu, Tian, Geng, Liang, Yuebin, Yuan, Peng

“…[Display omitted] HER2-positive breast cancer is a highly heterogeneous tumor, and about 30% of patients still suffer from recurrence and metastasis after…”
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Blockchain Technology for Healthcare: Facilitating the Transition to Patient-Driven Interoperability Autor Gordon, William J., Catalini, Christian

“…Interoperability in healthcare has traditionally been focused around data exchange between business entities, for example, different hospital systems. However,…”
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The genomics of oxidative DNA damage, repair, and resulting mutagenesis Autor Poetsch, Anna R.

“…[Display omitted] Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of disrupting genome function, inducing genome…”
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FHIRChain: Applying Blockchain to Securely and Scalably Share Clinical Data Autor Zhang, Peng, White, Jules, Schmidt, Douglas C., Lenz, Gunther, Rosenbloom, S. Trent

“…Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which…”
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