Výsledky vyhledávání - "Complement C3"

Modulating the complement system through epitope-specific inhibition by complement C3 inhibitors Autor Chen, Zhidong, Wang, Mingshuang, Duan, Wenqian, Xia, Yi, Liu, Huiqin, Qian, Feng

“…As an integral part of the innate immune system, the complement system is a tightly regulated proteolytic cascade, playing a critical role in microbial…”
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Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome Autor Frimat, Marie, Tabarin, Fanny, Dimitrov, Jordan D, Poitou, Caroline, Halbwachs-Mecarelli, Lise, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T

“…Atypical hemolytic uremic syndrome (aHUS) is characterized by genetic and acquired abnormalities of the complement system leading to alternative pathway (AP)…”
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C3 ‐dependent effector functions of complement Autor Zarantonello, Alessandra, Revel, Margot, Grunenwald, Anne, Roumenina, Lubka T.

“…C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding…”
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C5 nephritic factors drive the biological phenotype of C3 glomerulopathies Autor Marinozzi, Maria-Chiara, Chauvet, Sophie, Le Quintrec, Moglie, Mignotet, Morgane, Petitprez, Florent, Legendre, Christophe, Cailliez, Mathilde, Deschenes, Georges, Fischbach, Michel, Karras, Alexandre, Nobili, Francois, Pietrement, Christine, Dragon-Durey, Marie-Agnes, Fakhouri, Fadi, Roumenina, Lubka T, Fremeaux-Bacchi, Veronique

“…C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase…”
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Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis Autor Boire, Adrienne, Zou, Yilong, Shieh, Jason, Macalinao, Danilo G, Pentsova, Elena, Massagué, Joan

“…We molecularly dissected leptomeningeal metastasis, or spread of cancer to the cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by…”
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Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline Autor Shi, Qiaoqiao, Colodner, Kenneth J, Matousek, Sarah B, Merry, Katherine, Hong, Soyon, Kenison, Jessica E, Frost, Jeffrey L, Le, Kevin X, Li, Shaomin, Dodart, Jean-Cosme, Caldarone, Barbara J, Stevens, Beth, Lemere, Cynthia A

“…The complement system is part of the innate immune response responsible for removing pathogens and cellular debris, in addition to helping to refine CNS…”
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The role of complement in C3 glomerulopathy Autor Zipfel, Peter F., Skerka, Christine, Chen, Qian, Wiech, Thorsten, Goodship, Tim, Johnson, Sally, Fremeaux-Bacchi, Veronique, Nester, Clara, Córdoba, Santiago Rodríguez de, Noris, Marina, Pickering, Matthew, Smith, Richard

“…•C3 glomerulopathy is a complement mediated kidney disease.•It is caused by defective alternative pathway regulation frequently on the level of the C3…”
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Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy Autor Mastellos, Dimitrios C., Pires da Silva, Bruno G.P., Fonseca, Benedito A.L., Fonseca, Natasha P., Auxiliadora-Martins, Maria, Mastaglio, Sara, Ruggeri, Annalisa, Sironi, Marina, Radermacher, Peter, Chrysanthopoulou, Akrivi, Skendros, Panagiotis, Ritis, Konstantinos, Manfra, Ilenia, Iacobelli, Simona, Huber-Lang, Markus, Nilsson, Bo, Yancopoulou, Despina, Connolly, E. Sander, Garlanda, Cecilia, Ciceri, Fabio, Risitano, Antonio M., Calado, Rodrigo T., Lambris, John D.

“…Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven…”
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Complement pathway activation mediates pancreatic cancer–induced muscle wasting and pathological remodeling Autor D’Lugos, Andrew C., Ducharme, Jeremy B., Callaway, Chandler S., Trevino, Jose G., Atkinson, Carl, Judge, Sarah M., Judge, Andrew R.

“…Cancer cachexia is a multifactorial condition characterized by skeletal muscle wasting that impairs quality of life and longevity for many cancer patients. A…”
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Complement genes contribute sex-biased vulnerability in diverse disorders Autor Kamitaki, Nolan, Sekar, Aswin, Handsaker, Robert E., de Rivera, Heather, Tooley, Katherine, Morris, David L., Taylor, Kimberly E., Whelan, Christopher W., Tombleson, Philip, Loohuis, Loes M. Olde, Boehnke, Michael, Kimberly, Robert P., Kaufman, Kenneth M., Harley, John B., Langefeld, Carl D., Seidman, Christine E., Pato, Michele T., Pato, Carlos N., Ophoff, Roel A., Graham, Robert R., Criswell, Lindsey A., Vyse, Timothy J., McCarroll, Steven A.

“…Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus…”
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Alternative complement pathway assessment in patients with atypical HUS Autor Roumenina, Lubka T., Loirat, Chantal, Dragon-Durey, Marie-Agnes, Halbwachs-Mecarelli, Lise, Sautes-Fridman, Catherine, Fremeaux-Bacchi, Veronique

“…The atypical Hemolytic Uremic Syndrome (aHUS) is a rare thrombotic microangiopathy leading to end stage renal disease in approximately 60% of patients. Over…”
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Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model Autor Du, Miaomiao, Wang, Yujia, Wang, Xinyuan, Liu, Yifei, Xiao, Fuchuan, Zhang, Jing, Meng, Xia, Ma, Kunhe, Wu, Na, Chen, Baian, Lu, Jing

“…ABSTRACT Aging is the greatest risk factor for learning and memory disorders; dementia prevalence significantly increases with age due to numerous molecular…”
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Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis Autor Xavier, Sandhya, Sahu, Ranjit K, Landes, Susan G, Yu, Jing, Taylor, Ronald P, Ayyadevara, Srinivas, Megyesi, Judit, Stallcup, William B, Duffield, Jeremy S, Reis, Edimara S, Lambris, John D, Portilla, Didier

“…We have examined the pathogenic role of increased complement expression and activation during kidney fibrosis. Here, we show that PDGFRβ-positive pericytes…”
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Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion Autor Yamamoto, Tsunehisa, Tamaki, Kayoko, Shirakawa, Kohsuke, Ito, Kentaro, Yan, Xiaoxiang, Katsumata, Yoshinori, Anzai, Atsushi, Matsuhashi, Tomohiro, Endo, Jin, Inaba, Takaaki, Tsubota, Kazuo, Sano, Motoaki, Fukuda, Keiichi, Shinmura, Ken

“…Caloric restriction (CR) confers cardioprotection against ischemia-reperfusion (I/R) injury. We previously found the essential roles of endothelial nitric…”
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Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells Autor Kolev, Martin, West, Erin E, Kunz, Natalia, Chauss, Daniel, Moseman, E Ashley, Rahman, Jubayer, Freiwald, Tilo, Balmer, Maria L, Lötscher, Jonas, Dimeloe, Sarah, Rosser, Elizabeth C, Wedderburn, Lucy R, Mayer-Barber, Katrin D, Bohrer, Andrea, Lavender, Paul, Cope, Andrew, Wang, Luopin, Kaplan, Mariana J, Moutsopoulos, Niki M, McGavern, Dorian, Holland, Steven M, Hess, Christoph, Kazemian, Majid, Afzali, Behdad, Kemper, Claudia

“…Intrinsic complement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell responses. Increased or decreased intracellular C3 results in…”
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Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages Autor Francisco da Silva, Tiago, Akemi Amamura, Thaís, Cordeiro Valadão, Iuri, Carvalho Carneiro, Milena, Morais Freitas, Vanessa, Paula Lepique, Ana, Isaac, Lourdes

“…[Display omitted] •The lack of C3 causes morphological alterations in peritoneal macrophages.•The lack of C3 increases the levels of CD11c in macrophages.•The…”
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Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia Autor Scott‐Hewitt, Nicole, Perrucci, Fabio, Morini, Raffaella, Erreni, Marco, Mahoney, Matthew, Witkowska, Agata, Carey, Alanna, Faggiani, Elisa, Schuetz, Lisa Theresia, Mason, Sydney, Tamborini, Matteo, Bizzotto, Matteo, Passoni, Lorena, Filipello, Fabia, Jahn, Reinhard, Stevens, Beth, Matteoli, Michela

“…Neuronal circuit assembly requires the fine balance between synapse formation and elimination. Microglia, through the elimination of supernumerary synapses,…”
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Improved immunocompatibility of active targeting liposomes by attenuating nucleophilic attack of cyclic RGD peptides on complement 3 Autor Meng, Nana, Lu, Jiasheng, Zhou, Jianfen, Yang, Shengmin, Zhang, Chen, Jia, Ruiyi, Ding, Yuan, Bao, Yanning, Wang, Jun, Ma, Xiaopei, Chen, Ruohan, Jiang, Zhixuan, Xie, Cao, Lu, Linwei, Lu, Weiyue

“…One of the challenges for the clinical translation of active targeting nanomedicines is the adverse interactions between targeting ligands and blood…”
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Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease Autor Werneburg, Sebastian, Jung, Jonathan, Kunjamma, Rejani B, Ha, Seung-Kwon, Luciano, Nicholas J, Willis, Cory M, Gao, Guangping, Biscola, Natalia P, Havton, Leif A, Crocker, Stephen J, Popko, Brian, Reich, Daniel S, Schafer, Dorothy P

“…Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on myelin and axon loss in MS, less is…”
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Marginal zone B cells acquire dendritic cell functions by trogocytosis Autor Schriek, Patrick, Ching, Alan C, Moily, Nagaraj S, Moffat, Jessica, Beattie, Lynette, Steiner, Thiago M, Hosking, Laine M, Thurman, Joshua M, Holers, V Michael, Ishido, Satoshi, Lahoud, Mireille H, Caminschi, Irina, Heath, William R, Mintern, Justine D, Villadangos, Jose A

“…Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, antibody production requires MZ B…”
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