Search Results - "Cold Spring Harbor perspectives in biology"

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases by Erkkinen, Michael G, Kim, Mee-Ohk, Geschwind, Michael D

“…Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in older adults. Most clinicians who care for the elderly are not trained…”
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Pathology of Neurodegenerative Diseases by Dugger, Brittany N, Dickson, Dennis W

“…Neurodegenerative disorders are characterized by progressive loss of selectively vulnerable populations of neurons, which contrasts with select static neuronal…”
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Glycolysis by Chandel, Navdeep S

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What Are 3' UTRs Doing? by Mayr, Christine

“…3' untranslated regions (3' UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and…”
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TGF-β1 Signaling and Tissue Fibrosis by Kim, Kevin K, Sheppard, Dean, Chapman, Harold A

“…Activation of TGF-β1 initiates a program of temporary collagen accumulation important to wound repair in many organs. However, the outcome of temporary…”
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Interleukin-6 Family Cytokines by Rose-John, Stefan

“…The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor…”
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Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity by Alspach, Elise, Lussier, Danielle M, Schreiber, Robert D

“…Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now known to represent a distinct member of the IFN family…”
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Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease by Buckley, Aaron, Turner, Jerrold R

“…Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a selectively permeable barrier that supports nutrient absorption…”
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The Actin Cytoskeleton and Actin-Based Motility by Svitkina, Tatyana

“…The actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It…”
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Cytokines in Cancer Immunotherapy by Waldmann, Thomas A

“…Cytokines that control the immune response were shown to have efficacy in preclinical murine cancer models. Interferon (IFN)-α is approved for treatment of…”
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Epigenetic Determinants of Cancer by Baylin, Stephen B, Jones, Peter A

“…SUMMARYEpigenetic changes are present in all human cancers and are now known to cooperate with genetic alterations to drive the cancer phenotype. These changes…”
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TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology by Morikawa, Masato, Derynck, Rik, Miyazono, Kohei

“…The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals…”
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Microtubules and Microtubule-Associated Proteins by Goodson, Holly V, Jonasson, Erin M

“…Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the…”
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Functional Amyloids by Otzen, Daniel, Riek, Roland

“…When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long…”
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Stress Granules and Processing Bodies in Translational Control by Ivanov, Pavel, Kedersha, Nancy, Anderson, Paul

“…Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA granules that dynamically sequester translationally inactive messenger…”
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The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family by Negishi, Hideo, Taniguchi, Tadatsugu, Yanai, Hideyuki

“…Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense and are essential for mobilizing immune responses to pathogens…”
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Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress by Wek, Ronald C

“…A central mechanism regulating translation initiation in response to environmental stress involves phosphorylation of the α subunit of eukaryotic initiation…”
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Cilia and Mucociliary Clearance by Bustamante-Marin, Ximena M, Ostrowski, Lawrence E

“…Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface…”
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Non-Smad Signaling Pathways of the TGF-β Family by Zhang, Ying E

“…Transforming growth factor β (TGF-β) and structurally related factors use several intracellular signaling pathways in addition to Smad signaling to regulate a…”
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TGF-β Signaling from Receptors to Smads by Hata, Akiko, Chen, Ye-Guang

“…Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic factors that play critical roles in embryogenesis and adult tissue…”
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