Suchergebnisse - "Clinical trials"

Medical Research for Hire: The Political Economy of Pharmaceutical Clinical Trials von Fisher, Jill A

“… , they are attracted to pharmaceutical contract research for its lucrative return. Clinical trials also provide limited medical access to individuals who have no or inadequate …”
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Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (ID‐COSM) international consensus report von Tonetti, Maurizio S., Sanz, Mariano, Avila‐Ortiz, Gustavo, Berglundh, Tord, Cairo, Francesco, Derks, Jan, Figuero, Elena, Graziani, Filippo, Guerra, Fernando, Heitz‐Mayfield, Lisa, Jung, Ronald E., Lai, Hongchang, Needleman, Ian, Papapanou, Panos N., Sailer, Irena, Sanz‐Sanchez, Ignacio, Schwarz, Frank, Shi, Junyu, Thoma, Daniel

“… The objective of this initiative was to develop a core outcome set (COS) and measurements for implant dentistry clinical trials (ID‐COSM …”
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COVID-19, Clinical Trials, and QT-Prolonging Prophylactic Therapy in Healthy Subjects: First, Do No Harm von Gollob, Michael H

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The Increasing Weight of Crohnʼs Disease Subjects in Clinical Trials: A Hypothesis-generatings Time-trend Analysis von Moran, Gordon W., Dubeau, Marie-France, Kaplan, Gilaad G., Panaccione, Remo, Ghosh, Subrata

“… We report on an analysis of body weight in CD clinical trials between 1991 and 2008. MEDLINE-based databases were searched for randomized controlled trials pertaining to CD …”
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Clinical trials in children von Joseph, Pathma D., Craig, Jonathan C., Caldwell, Patrina H.Y.

“… ‐use of beneficial therapies. Clinical trials provide reliable evidence of treatment effects by rigorous controlled testing of interventions on human subjects …”
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Non-publication of large randomized clinical trials: cross sectional analysis von Jones, Christopher W, Handler, Lara, Crowell, Karen E, Keil, Lukas G, Weaver, Mark A, Platts-Mills, Timothy F

“… Objective To estimate the frequency with which results of large randomized clinical trials registered …”
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Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials von Svarovskaia, Evguenia S, Dvory-Sobol, Hadas, Parkin, Neil, Hebner, Christy, Gontcharova, Viktoria, Martin, Ross, Ouyang, Wen, Han, Bin, Xu, Simin, Ku, Karin, Chiu, Sophia, Gane, Edward, Jacobson, Ira M, Nelson, David R, Lawitz, Eric, Wyles, David L, Bekele, Neby, Brainard, Diana, Symonds, William T, McHutchison, John G, Miller, Michael D, Mo, Hongmei

“… NS5B sequencing and susceptibility testing of HCV from subjects infected with genotypes 1-6 who participated in phase 2 and 3 sofosbuvir clinical trials was performed …”
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Participation of Women in Clinical Trials: Not Yet Time to Rest on Our Laurels von Pilote, Louise, Raparelli, Valeria

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Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I–III Clinical Trials von Klünder, Ben, Mittapalli, Rajendar K., Mohamed, Mohamed-Eslam F., Friedel, Anna, Noertersheuser, Peter, Othman, Ahmed A.

“… I–III clinical trials using data for immediate-release (IR) and extended-release (ER) formulations. Methods Pharmacokinetic data from 4170 subjects taking IR doses of 1 …”
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Effectiveness and Ethics of Incentives for Research Participation: 2 Randomized Clinical Trials von Halpern, Scott D, Chowdhury, Marzana, Bayes, Brian, Cooney, Elizabeth, Hitsman, Brian L, Schnoll, Robert A, Lubitz, Su Fen, Reyes, Celine, Patel, Mitesh S, Greysen, S Ryan, Mercede, Ashley, Reale, Catherine, Barg, Frances K, Volpp, Kevin G, Karlawish, Jason, Stephens-Shields, Alisa J

“… To determine whether incentives improve enrollment in real randomized clinical trials (RCTs) or serve as undue or unjust inducements …”
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Analysis of Female Enrollment and Participant Sex by Burden of Disease in US Clinical Trials Between 2000 and 2020 von Steinberg, Jecca R, Turner, Brandon E, Weeks, Brannon T, Magnani, Christopher J, Wong, Bonnie O, Rodriguez, Fatima, Yee, Lynn M, Cullen, Mark R

“… IMPORTANCE: Although female representation has increased in clinical trials, little is known about how clinical trial representation compares with burden of disease or is associated with clinical trial features …”
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Participants’ understanding of informed consent in clinical trials over three decades: systematic review and meta-analysis von Tam, Nguyen Thanh, Huy, Nguyen Tien, Thoa, Le Thi Bich, Long, Nguyen Phuoc, Trang, Nguyen Thi Huyen, Hirayama, Kenji, Karbwang, Juntra

“… To estimate the proportion of participants in clinical trials who understand different components of informed consent …”
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Inorganic nanoparticles in clinical trials and translations von Huang, Hui, Feng, Wei, Chen, Yu, Shi, Jianlin

“… [Display omitted] •The status quo of inorganic nanoparticles in clinical trials and translation is highlighted and summarized …”
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Minimizing Patient Burden Through the Use of Historical Subject-Level Data in Innovative Confirmatory Clinical Trials: Review of Methods and Opportunities von Lim, Jessica, Walley, Rosalind, Yuan, Jiacheng, Liu, Jeen, Dabral, Abhishek, Best, Nicky, Grieve, Andrew, Hampson, Lisa, Wolfram, Josephine, Woodward, Phil, Yong, Florence, Zhang, Xiang, Bowen, Ed

“… The goal of clinical trial research is to deliver safe and efficacious new treatments to patients in need in a timely and cost-effective manner …”
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Diversity in Clinical Trials — Next Steps von Rosen, Clifford J., Cook, Nakela L., Wilkins, Consuelo H.

“… What are the next steps in ensuring that participants in clinical trials reflect the diversity of the populations affected by the diseases under study …”
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Credibility assessment of in silico clinical trials for medical devices von Pathmanathan, Pras, Aycock, Kenneth, Badal, Andreu, Bighamian, Ramin, Bodner, Jeff, Craven, Brent A., Niederer, Steven

“… In silico clinical trials (ISCTs) are an emerging method in modeling and simulation where medical interventions are evaluated using computational models of patients …”
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Relevant domains, core outcome sets and measurements for implant dentistry clinical trials: The Implant Dentistry Core Outcome Set and Measurement (ID‐COSM) international consensus report von Tonetti, Maurizio S., Sanz, Mariano, Avila‐Ortiz, Gustavo, Berglundh, Tord, Cairo, Francesco, Derks, Jan, Figuero, Elena, Graziani, Filippo, Guerra, Fernando, Heitz‐Mayfield, Lisa, Jung, Ronald E., Lai, Hongchang, Needleman, Ian, Papapanou, Panos N., Sailer, Irena, Sanz‐Sanchez, Ignacio, Schwarz, Frank, Shi, Junyu, Thoma, Daniel

“… The objective of this initiative was to develop a core outcome set (COS) and measurements for implant dentistry clinical trials (ID‐COSM …”
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Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects With Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, or Atopic Dermatitis: Population Analyses of Phase 1 and 2 Clinical Trials von Nader, Ahmed, Stodtmann, Sven, Friedel, Anna, Mohamed, Mohamed‐Eslam F., Othman, Ahmed A.

“… A population pharmacokinetic model was developed for upadacitinib using 11,658 plasma concentrations from 1145 subjects from 4 phase 1 and 5 phase 2 studies in healthy subjects and subjects …”
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Characteristics of academic publications, preprints, and registered clinical trials on the COVID-19 pandemic von Gianola, Silvia, Jesus, Tiago S., Bargeri, Silvia, Castellini, Greta

“… of COVID-19-related academic articles and preprints and the number of ongoing clinical trials and systematic reviews …”
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Adequacy of Inclusion of Older Adults in NIH‐Funded Phase III Clinical Trials von Lockett, Jaron, Sauma, Samir, Radziszewska, Barbara, Bernard, Marie A.

“… However, it was reported that older adults are excluded or underrepresented in clinical trials for several diseases …”
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