Výsledky vyhledávání - "Clinical Trials and Supportive Activities"

Venetoclax Plus Gilteritinib for FLT3 -Mutated Relapsed/Refractory Acute Myeloid Leukemia Autor Daver, Naval, Perl, Alexander E, Maly, Joseph, Levis, Mark, Ritchie, Ellen, Litzow, Mark, McCloskey, James, Smith, Catherine C, Schiller, Gary, Bradley, Terrence, Tiu, Ramon V, Naqvi, Kiran, Dail, Monique, Brackman, Deanna, Siddani, Satya, Wang, Jing, Chyla, Brenda, Lee, Paul, Altman, Jessica K

“…The FMS-related tyrosine kinase 3 (FLT3) inhibitor gilteritinib is standard therapy for relapsed/refractory -mutated ( ) acute myeloid leukemia (AML) but…”
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Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209) Autor Miller, David S, Filiaci, Virginia L, Mannel, Robert S, Cohn, David E, Matsumoto, Takashi, Tewari, Krishnansu S, DiSilvestro, Paul, Pearl, Michael L, Argenta, Peter A, Powell, Matthew A, Zweizig, Susan L, Warshal, David P, Hanjani, Parviz, Carney, Michael E, Huang, Helen, Cella, David, Zaino, Richard, Fleming, Gini F

“…Limitations of the paclitaxel-doxorubicin-cisplatin (TAP) regimen in the treatment of endometrial cancer include tolerability and cumbersome scheduling. The…”
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Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer Autor Modi, Shanu, Saura, Cristina, Yamashita, Toshinari, Park, Yeon Hee, Kim, Sung-Bae, Tamura, Kenji, Andre, Fabrice, Iwata, Hiroji, Ito, Yoshinori, Tsurutani, Junji, Sohn, Joohyuk, Denduluri, Neelima, Perrin, Christophe, Aogi, Kenjiro, Tokunaga, Eriko, Im, Seock-Ah, Lee, Keun Seok, Hurvitz, Sara A, Cortes, Javier, Lee, Caleb, Chen, Shuquan, Zhang, Lin, Shahidi, Javad, Yver, Antoine, Krop, Ian

“…In this single-group, phase 2 study, the use of trastuzumab deruxtecan resulted in a response in 60% of women with HER2-positive advanced breast cancer who had…”
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Atezolizumab and nab-Paclitaxel in Advanced Triple-Negative Breast Cancer: Biomarker Evaluation of the IMpassion130 Study Autor Emens, Leisha A, Molinero, Luciana, Loi, Sherene, Rugo, Hope S, Schneeweiss, Andreas, Diéras, Véronique, Iwata, Hiroji, Barrios, Carlos H, Nechaeva, Marina, Nguyen-Duc, Anh, Chui, Stephen Y, Husain, Amreen, Winer, Eric P, Adams, Sylvia, Schmid, Peter

“…Abstract Background Understanding the impact of the tumor immune microenvironment and BRCA1/2-related DNA repair deficiencies on the clinical activity of…”
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A Randomized, Placebo‐Controlled Phase III Extension Trial of the Long‐Term Safety and Tolerability of Anifrolumab in Active Systemic Lupus Erythematosus Autor Kalunian, Kenneth C., Furie, Richard, Morand, Eric F., Bruce, Ian N., Manzi, Susan, Tanaka, Yoshiya, Winthrop, Kevin, Hupka, Ihor, Zhang, Lijin (Jinny), Werther, Shanti, Abreu, Gabriel, Hultquist, Micki, Tummala, Raj, Lindholm, Catharina, Al‐Mossawi, Hussein

“…Objective To explore long‐term safety and tolerability of anifrolumab 300 mg compared with placebo in patients with systemic lupus erythematosus (SLE) who…”
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Global challenges of radiotherapy for the treatment of locally advanced cervical cancer Autor Mayadev, Jyoti S, Ke, Guihao, Mahantshetty, Umesh, Pereira, Marcos David, Tarnawski, Rafal, Toita, Takafumi

“…Cervical cancer represents a significant portion of the global cancer burden for women, with low- and middle-income countries carrying the bulk of this burden…”
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Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel Autor Ference, Brian A, Ginsberg, Henry N, Graham, Ian, Ray, Kausik K, Packard, Chris J, Bruckert, Eric, Hegele, Robert A, Krauss, Ronald M, Raal, Frederick J, Schunkert, Heribert, Watts, Gerald F, Borén, Jan, Fazio, Sergio, Horton, Jay D, Masana, Luis, Nicholls, Stephen J, Nordestgaard, Børge G, van de Sluis, Bart, Taskinen, Marja-Riitta, Tokgözoglu, Lale, Landmesser, Ulf, Laufs, Ulrich, Wiklund, Olov, Stock, Jane K, Chapman, M John, Catapano, Alberico L

“…To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD). We assessed whether…”
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Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults Autor LeBoff, Meryl S., Chou, Sharon H., Ratliff, Kristin A., Cook, Nancy R., Khurana, Bharti, Kim, Eunjung, Cawthon, Peggy M., Bauer, Douglas C., Black, Dennis, Gallagher, J. Chris, Lee, I-Min, Buring, Julie E., Manson, JoAnn E.

“…A study ancillary to a large trial showed that supplemental vitamin D 3 did not lower the risk of fractures among generally healthy midlife and older adults…”
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Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers Autor Dunican, Eleanor M, Elicker, Brett M, Henry, Travis, Gierada, David S, Schiebler, Mark L, Anderson, Wayne, Barjaktarevic, Igor, Barr, R Graham, Bleecker, Eugene R, Boucher, Richard C, Bowler, Russell, Christenson, Stephanie A, Comellas, Alejandro, Cooper, Christopher B, Couper, David, Criner, Gerard J, Dransfield, Mark, Doerschuk, Claire M, Drummond, M Bradley, Hansel, Nadia N, Han, MeiLan K, Hastie, Annette T, Hoffman, Eric A, Krishnan, Jerry A, Lazarus, Stephen C, Martinez, Fernando J, McCulloch, Charles E, O'Neal, Wanda K, Ortega, Victor E, Paine, 3rd, Robert, Peters, Stephen, Schroeder, Joyce D, Woodruff, Prescott G, Fahy, John V

“…The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD)…”
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Induced pluripotent stem cell technology: a decade of progress Autor Shi, Yanhong, Inoue, Haruhisa, Wu, Joseph C., Yamanaka, Shinya

“…Key Points Human induced pluripotent stem cell (iPSC) technology has evolved rapidly since its inception in 2007. Human iPSC technology has been widely used…”
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Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study Autor Walker, Joan L, Brady, Mark F, Wenzel, Lari, Fleming, Gini F, Huang, Helen Q, DiSilvestro, Paul A, Fujiwara, Keiichi, Alberts, David S, Zheng, Wenxin, Tewari, Krishnansu S, Cohn, David E, Powell, Matthew A, Van Le, Linda, Davidson, Susan A, Gray, Heidi J, Rose, Peter G, Aghajanian, Carol, Myers, Tashanna, Alvarez Secord, Angeles, Rubin, Stephen C, Mannel, Robert S

“…To evaluate the impact of two different intraperitoneal (IP) chemotherapy regimens on progression-free survival (PFS) among women with newly diagnosed advanced…”
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Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2 Autor Piccart, M, Hortobagyi, G N, Campone, M, Pritchard, K I, Lebrun, F, Ito, Y, Noguchi, S, Perez, A, Rugo, H S, Deleu, I, Burris, 3rd, H A, Provencher, L, Neven, P, Gnant, M, Shtivelband, M, Wu, C, Fan, J, Feng, W, Taran, T, Baselga, J

“…The BOLERO-2 study previously demonstrated that adding everolimus (EVE) to exemestane (EXE) significantly improved progression-free survival (PFS) by more than…”
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Enzalutamide in Metastatic Prostate Cancer before Chemotherapy Autor Beer, Tomasz M, Armstrong, Andrew J, Rathkopf, Dana E, Loriot, Yohann, Sternberg, Cora N, Higano, Celestia S, Iversen, Peter, Bhattacharya, Suman, Carles, Joan, Chowdhury, Simon, Davis, Ian D, de Bono, Johann S, Evans, Christopher P, Fizazi, Karim, Joshua, Anthony M, Kim, Choung-Soo, Kimura, Go, Mainwaring, Paul, Mansbach, Harry, Miller, Kurt, Noonberg, Sarah B, Perabo, Frank, Phung, De, Saad, Fred, Scher, Howard I, Taplin, Mary-Ellen, Venner, Peter M, Tombal, Bertrand

“…In this study, the androgen-receptor inhibitor enzalutamide improved progression-free and overall survival in men with castration-resistant metastatic prostate…”
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Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract Autor Mach, François, Ray, Kausik K, Wiklund, Olov, Corsini, Alberto, Catapano, Alberico L, Bruckert, Eric, De Backer, Guy, Hegele, Robert A, Hovingh, G Kees, Jacobson, Terry A, Krauss, Ronald M, Laufs, Ulrich, Leiter, Lawrence A, März, Winfried, Nordestgaard, Børge G, Raal, Frederick J, Roden, Michael, Santos, Raul D, Stein, Evan A, Stroes, Erik S, Thompson, Paul D, Tokgözoğlu, Lale, Vladutiu, Georgirene D, Gencer, Baris, Stock, Jane K, Ginsberg, Henry N, Chapman, M John

“…Abstract Aims To objectively appraise evidence for possible adverse effects of long-term statin therapy on glucose homeostasis, cognitive, renal and hepatic…”
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Global connectivity and local excitability changes underlie antidepressant effects of repetitive transcranial magnetic stimulation Autor Eshel, Neir, Keller, Corey J, Wu, Wei, Jiang, Jing, Mills-Finnerty, Colleen, Huemer, Julia, Wright, Rachael, Fonzo, Gregory A, Ichikawa, Naho, Carreon, David, Wong, Melinda, Yee, Andrew, Shpigel, Emmanuel, Guo, Yi, McTeague, Lisa, Maron-Katz, Adi, Etkin, Amit

“…Repetitive transcranial magnetic stimulation (rTMS) is a commonly- used treatment for major depressive disorder (MDD). However, our understanding of the…”
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Neurodevelopmental outcomes after cardiac surgery in infancy Autor Gaynor, J William, Stopp, Christian, Wypij, David, Andropoulos, Dean B, Atallah, Joseph, Atz, Andrew M, Beca, John, Donofrio, Mary T, Duncan, Kim, Ghanayem, Nancy S, Goldberg, Caren S, Hövels-Gürich, Hedwig, Ichida, Fukiko, Jacobs, Jeffrey P, Justo, Robert, Latal, Beatrice, Li, Jennifer S, Mahle, William T, McQuillen, Patrick S, Menon, Shaji C, Pemberton, Victoria L, Pike, Nancy A, Pizarro, Christian, Shekerdemian, Lara S, Synnes, Anne, Williams, Ismee, Bellinger, David C, Newburger, Jane W

“…Neurodevelopmental disability is the most common complication for survivors of surgery for congenital heart disease (CHD). We analyzed individual participant…”
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Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial Autor Dam, Tien, Boxer, Adam L., Golbe, Lawrence I., Höglinger, Günter U., Morris, Huw R., Litvan, Irene, Lang, Anthony E., Corvol, Jean-Christophe, Aiba, Ikuko, Grundman, Michael, Yang, Lili, Tidemann-Miller, Beth, Kupferman, Joseph, Harper, Kristine, Kamisoglu, Kubra, Wald, Michael J., Graham, Danielle L., Gedney, Liz, O’Gorman, John, Haeberlein, Samantha Budd

“…A randomized, double-blind, placebo-controlled, 52-week study (no. NCT03068468) evaluated gosuranemab, an anti-tau monoclonal antibody, in the treatment of…”
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Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2 Autor Hortobagyi, Gabriel N, Chen, David, Piccart, Martine, Rugo, Hope S, Burris, 3rd, Howard A, Pritchard, Kathleen I, Campone, Mario, Noguchi, Shinzaburo, Perez, Alejandra T, Deleu, Ines, Shtivelband, Mikhail, Masuda, Norikazu, Dakhil, Shaker, Anderson, Ian, Robinson, Douglas M, He, Wei, Garg, Abhishek, McDonald, 3rd, E Robert, Bitter, Hans, Huang, Alan, Taran, Tetiana, Bachelot, Thomas, Lebrun, Fabienne, Lebwohl, David, Baselga, José

“…To explore the genetic landscape of tumors from patients enrolled on the BOLERO-2 trial to identify potential correlations between genetic alterations and…”
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Estetrol‐Drospirenone combination oral contraceptive: a clinical study of contraceptive efficacy, bleeding pattern and safety in Europe and Russia Autor Gemzell‐Danielsson, K, Apter, D, Zatik, J, Weyers, S, Piltonen, T, Suturina, L, Apolikhina, I, Jost, M, Creinin, MD, Foidart, J‐M

“…Objectives To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone…”
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A Fifty‐Two–Week, Randomized, Placebo‐Controlled Trial of Certolizumab Pegol in Nonradiographic Axial Spondyloarthritis Autor Deodhar, Atul, Gensler, Lianne S., Kay, Jonathan, Maksymowych, Walter P., Haroon, Nigil, Landewé, Robert, Rudwaleit, Martin, Hall, Stephen, Bauer, Lars, Hoepken, Bengt, Peyrecave, Natasha, Kilgallen, Brian, Heijde, Désirée

“…Objective The natural history of nonradiographic axial spondyloarthritis (SpA) is incompletely characterized, and there are concerns that nonsteroidal…”
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