Suchergebnisse - "Claessen, Nike"

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity von Stokman, Geurt, Kors, Lotte, Bakker, Pieter J, Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J D, Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A, Larsen, Per W B, Dessing, Mark C, Zuurbier, Coert J, Girardin, Stephen E, Florquin, Sandrine, Leemans, Jaklien C

“… Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system …”
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Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury von Emal, Diba, Rampanelli, Elena, Stroo, Ingrid, Butter, Loes M, Teske, Gwendoline J, Claessen, Nike, Stokman, Geurt, Florquin, Sandrine, Leemans, Jaklien C, Dessing, Mark C

“… An accumulating body of evidence shows that gut microbiota fulfill an important role in health and disease by modulating local and systemic immunity. The …”
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Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-β signaling pathway von Rustiasari, Ukhti Jamil, Uil, Melissa, Zhang, Xiaomeng, Claessen, Nike, Butter, Loes, Florquin, Sandrine, Tammaro, Alessandra, Roelofs, Joris J.T.H.

“… Background Management of chronic kidney disease (CKD) remains a major challenge due limited therapeutic options to reverse fibrosis, which is a critical …”
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Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection von Emal, Diba, Rampanelli, Elena, Claessen, Nike, Bemelman, Frederike J., Leemans, Jaklien C., Florquin, Sandrine, Dessing, Mark C.

“… Calcineurin inhibitor Tacrolimus, is a potent immunosuppressive drug widely used in order to prevent acute graft rejection. Urinary tract infection (UTI) is …”
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A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion von Bakker, Pieter J, Butter, Loes M, Claessen, Nike, Teske, Gwendoline J D, Sutterwala, Fayyaz S, Florquin, Sandrine, Leemans, Jaklien C

“… Ischemia/reperfusion injury is a major cause of acute kidney injury. Improving renal repair would represent a therapeutic strategy to prevent renal …”
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TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury von Pulskens, Wilco P, Rampanelli, Elena, Teske, Gwendoline J, Butter, Loes M, Claessen, Nike, Luirink, Ilse K, van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C

“… Toll-like receptors (TLRs) can orchestrate an inflammatory response upon activation by pathogen-associated motifs and release of endogenous stress ligands …”
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The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion von Dessing, Mark C., Tammaro, Alessandra, Pulskens, Wilco P., Teske, Gwendoline J., Butter, Loes M., Claessen, Nike, van Eijk, Marco, van der Poll, Tom, Vogl, Thomas, Roth, Johannes, Florquin, Sandrine, Leemans, Jaklien C.

“… Upon ischemia/reperfusion (I/R)-induced injury, several damage-associated molecular patterns are expressed including the calcium-binding protein S100A8/A9 …”
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Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney von Rampanelli, Elena, Ochodnicky, Peter, Vissers, Johannes PC, Butter, Loes M, Claessen, Nike, Calcagni, Alessia, Kors, Lotte, Gethings, Lee A, Bakker, Stephan JL, de Borst, Martin H, Navis, Gerjan J, Liebisch, Gerhard, Speijer, Dave, van den Bergh Weerman, Marius A, Jung, Bettina, Aten, Jan, Steenbergen, Eric, Schmitz, Gerd, Ballabio, Andrea, Florquin, Sandrine, Aerts, Johannes MFG, Leemans, Jaklien C

“… Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic …”
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Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney von Leemans, Jaklien C., Stokman, Geurt, Claessen, Nike, Rouschop, Kasper M., Teske, Gwendoline J.D., Kirschning, Carsten J., Akira, Shizuo, van der Poll, Tom, Weening, Jan J., Florquin, Sandrine

“… TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA …”
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Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation von Rampanelli, Elena, Orsó, Evelyn, Ochodnicky, Peter, Liebisch, Gerhard, Bakker, Pieter J., Claessen, Nike, Butter, Loes M., van den Bergh Weerman, Marius A., Florquin, Sandrine, Schmitz, Gerd, Leemans, Jaklien C.

“… The collateral effects of obesity/metabolic syndrome include inflammation and renal function decline. As renal disease in obesity can occur independently of …”
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Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease von Marques, André R. A., Gabriel, Tanit L., Aten, Jan, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Claessen, Nike, Alfonso, Pilar, Irún, Pilar, Giraldo, Pilar, Aerts, Johannes M. F. G., van Eijk, Marco

“… Impaired function of NPC1 or NPC2 lysosomal proteins leads to the intracellular accumulation of unesterified cholesterol, the primary defect underlying …”
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Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction von Gabriel, Tanit L, Tol, Marc J, Ottenhof, Roelof, van Roomen, Cindy, Aten, Jan, Claessen, Nike, Hooibrink, Berend, de Weijer, Barbara, Serlie, Mireille J, Argmann, Carmen, van Elsenburg, Leonie, Aerts, Johannes M F G, van Eijk, Marco

“… In obesity, adipose tissue (AT) contains crown-like structures where macrophages surround nonviable adipocytes. To understand how AT macrophages (ATMs) …”
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Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice von Marques, André R. A., Aten, Jan, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Herrera Moro, Daniela, Claessen, Nike, Vinueza Veloz, María Fernanda, Zhou, Kuikui, Lin, Zhanmin, Mirzaian, Mina, Boot, Rolf G., De Zeeuw, Chris I., Overkleeft, Herman S., Yildiz, Yildiz, Aerts, Johannes M. F. G.

“… The enzyme glucocerebrosidase (GBA) hydrolyses glucosylceramide (GlcCer) in lysosomes. Markedly reduced GBA activity is associated with severe manifestations …”
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TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion von Bakker, Pieter J., Scantlebery, Angelique M., Butter, Loes M., Claessen, Nike, Teske, Gwendoline J. D., van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C.

“… Ischemia reperfusion injury is a common cause of acute kidney injury and is characterized by tubular damage. Mitochondrial DNA is released upon severe tissue …”
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TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells von Tammaro, Alessandra, Scantlebery, Angelique M. L., Rampanelli, Elena, Borrelli, Cristiana, Claessen, Nike, Butter, Loes M., Soriani, Alessandra, Colonna, Marco, Leemans, Jaklien C., Dessing, Mark C., Florquin, Sandrine

“… Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), …”
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Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction von Pulskens, Wilco P., Butter, Loes M., Teske, Gwendoline J., Claessen, Nike, Dessing, Mark C., Flavell, Richard A., Sutterwala, Fayyaz S., Florquin, Sandrine, Leemans, Jaklien C.

“… Progressive renal disease is characterized by tubulo-interstitial injury with ongoing inflammation and fibrosis. The Nlrp3 inflammasome contributes to these …”
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Deficiency for the Chemokine Monocyte Chemoattractant Protein-1 Aggravates Tubular Damage after Renal Ischemia/Reperfusion Injury von Stroo, Ingrid, Claessen, Nike, Teske, Gwendoline J. D., Butter, Loes M., Florquin, Sandrine, Leemans, Jaklien C.

“… Temporal expression of chemokines is a crucial factor in the regulation of renal ischemia/reperfusion (I/R) injury and repair. Beside their role in the …”
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NLRX1 does not play a role in diabetes nor the development of diabetic nephropathy induced by multiple low doses of streptozotocin von Scantlebery, Angelique M. L., Uil, Melissa, Butter, Loes M., Poelman, Renée, Claessen, Nike, Girardin, Stephen E., Florquin, Sandrine, Roelofs, Joris J. T. H., Leemans, Jaklien C.

“… Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus that results in both tubular and glomerular injury. Low-grade inflammation and …”
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NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy von Liu, Ye, Kors, Lotte, Butter, Loes M., Stokman, Geurt, Claessen, Nike, Zuurbier, Coert J., Girardin, Stephen E., Leemans, Jaklien C., Florquin, Sandrine, Tammaro, Alessandra

“… Background: Chronic kidney disease often leads to kidney dysfunction due to renal fibrosis, regardless of the initial cause of kidney damage. Macrophages are …”
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The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury von Leemans, Jaklien C., Butter, Loes M., Pulskens, Wilco P. C., Teske, Gwendoline J. D., Claessen, Nike, van der Poll, Tom, Florquin, Sandrine

“… Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological …”
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