Search Results - "Citterio, Elisabetta"

Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work by Citterio, Elisabetta

“…Ubiquitination is a reversible protein modification broadly implicated in cellular functions. Signaling processes mediated by ubiquitin (ub) are crucial for…”
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COUP-TFII regulates hemoglobin switching by activating the BCL11A-XL repressor Lin28B and directly binding δ and β globin promoters in fetal versus adult erythroid cells by Frigo, Carlotta, Pastori, Valentina, Zambanini, Gianluca, Fabiano, Martina, Ahmed, Sajeela, Citterio, Elisabetta, Cantù, Claudio, Ronchi, Antonella Ellena

“…The reactivation of fetal globin genes is the most promising treatment for β-hemoglobinopathies. This implies the reversal of the naturally occurring…”
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DNA damage tolerance in hematopoietic stem and progenitor cells in mice by Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul, Lancini, Cesare, Song, Ji-Ying, Citterio, Elisabetta, Jacobs, Heinz

“…DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage…”
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BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair by Ginjala, Vasudeva, Nacerddine, Karim, Kulkarni, Atul, Oza, Jay, Hill, Sarah J., Yao, Ming, Citterio, Elisabetta, van Lohuizen, Maarten, Ganesan, Shridar

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6 by Pastori, Valentina, Zambanini, Gianluca, Citterio, Elisabetta, Weiss, Tamina, Nakamura, Yukio, Cantù, Claudio, Ronchi, Antonella Ellena

“…The identification of regulatory networks contributing to fetal/adult gene expression switches is a major challenge in developmental biology and key to…”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells by Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“…Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification…”
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DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A by Bergink, Steven, Salomons, Florian A, Hoogstraten, Deborah, Groothuis, Tom A M, de Waard, Harm, Wu, Junxin, Yuan, Li, Citterio, Elisabetta, Houtsmuller, Adriaan B, Neefjes, Jacques, Hoeijmakers, Jan H J, Vermeulen, Wim, Dantuma, Nico P

“…Chromatin changes within the context of DNA repair remain largely obscure. Here we show that DNA damage induces monoubiquitylation of histone H2A in the…”
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Np95 is a histone-binding protein endowed with ubiquitin ligase activity by Citterio, Elisabetta, Papait, Roberto, Nicassio, Francesco, Vecchi, Manuela, Gomiero, Paola, Mantovani, Roberto, Di Fiore, Pier Paolo, Bonapace, Ian Marc

“…Np95 is an important determinant in cell cycle progression. Its expression is tightly regulated and becomes detectable shortly before the entry of cells into S…”
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ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor by Citterio, E, Van Den Boom, V, Schnitzler, G, Kanaar, R, Bonte, E, Kingston, R E, Hoeijmakers, J H, Vermeulen, W

“…The Cockayne syndrome B protein (CSB) is required for coupling DNA excision repair to transcription in a process known as transcription-coupled repair (TCR)…”
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The many faces of ubiquitinated histone H2A: insights from the DUBs by Vissers, Joseph HA, Nicassio, Francesco, van Lohuizen, Maarten, Di Fiore, Pier Paolo, Citterio, Elisabetta

“…Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in…”
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Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation by Citterio, Elisabetta, Ronchi, Antonella Ellena

“…Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the…”
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Quantitative analysis by next generation sequencing of hematopoietic stem and progenitor cells (LSK) and of splenic B cells transcriptomes from wild-type and Usp3-knockout mice by Lancini, Cesare, Gargiulo, Gaetano, van den Berk, Paul C.M., Citterio, Elisabetta

“…The data described here provide genome-wide expression profiles of murine primitive hematopoietic stem and progenitor cells (LSK) and of B cell populations,…”
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UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II by Rockx, D A, Mason, R, van Hoffen, A, Barton, M C, Citterio, E, Bregman, D B, van Zeeland, A A, Vrieling, H, Mullenders, L H

“…Cells from patients with Cockayne syndrome (CS) are hypersensitive to DNA-damaging agents and are unable to restore damage-inhibited RNA synthesis. On the…”
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Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair by Kamiuchi, Shinya, Saijo, Masafumi, Citterio, Elisabetta, de Jager, Martijn, Hoeijmakers, Jan H J, Tanaka, Kiyoji

“…Transcription-coupled repair (TCR) efficiently removes a variety of lesions from the transcribed strand of active genes. By allowing rapid resumption of RNA…”
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Elisabetta Citterio brings together science and art with "STEM Passion" by Ruffell, Daniela

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XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription by Nakatsu, Y, Asahina, H, Citterio, E, Rademakers, S, Vermeulen, W, Kamiuchi, S, Yeo, J P, Khaw, M C, Saijo, M, Kodo, N, Matsuda, T, Hoeijmakers, J H, Tanaka, K

“…Nucleotide excision repair is a highly versatile DNA repair system responsible for elimination of a wide variety of lesions from the genome. It is comprised of…”
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Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein by Citterio, E, Rademakers, S, van der Horst, G T, van Gool, A J, Hoeijmakers, J H, Vermeulen, W

“…Cockayne syndrome (CS) is a nucleotide excision repair disorder characterized by sun (UV) sensitivity and severe developmental problems. Two genes have been…”
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RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling by Mattiroli, Francesca, Vissers, Joseph H A, van Dijk, Willem J, Ikpa, Pauline, Citterio, Elisabetta, Vermeulen, Wim, Marteijn, Jurgen A, Sixma, Titia K

“…Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting…”
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Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer by Serresi, Michela, Gargiulo, Gaetano, Proost, Natalie, Siteur, Bjorn, Cesaroni, Matteo, Koppens, Martijn, Xie, Huafeng, Sutherland, Kate D, Hulsman, Danielle, Citterio, Elisabetta, Orkin, Stuart, Berns, Anton, van Lohuizen, Maarten

“…Polycomb repressive complexes (PRC) are frequently implicated in human cancer, acting either as oncogenes or tumor suppressors. Here, we show that PRC2 is a…”
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Transcription Factors, R-Loops and Deubiquitinating Enzymes: Emerging Targets in Myelodysplastic Syndromes and Acute Myeloid Leukemia by Barabino, Silvia M. L., Citterio, Elisabetta, Ronchi, Antonella Ellena

“…Myeloid neoplasms encompass a very heterogeneous family of diseases characterized by the failure of the molecular mechanisms that ensure a balanced equilibrium…”
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