Suchergebnisse - "Cisplatin - pharmacology"

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy von Lin, Changwei, Chen, Yifei, Zhang, Fan, Liu, Baiying, Xie, Canbin, Song, Yexun

“… In our research, the HSCC cell line FaDu and the DDP-resistant cell line FaDu/DDP were used as subjects …”
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FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer von Zhou, Jinhua, Wang, Yunfei, Wang, You, Yin, Xia, He, Yifeng, Chen, Lilan, Wang, Wenwen, Liu, Ting, Di, Wen

“… Cisplatin is commonly used in ovarian cancer chemotherapy, however, chemoresistance to cisplatin remains a great clinical challenge. Oncogenic transcriptional …”
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The unique Pt(II)-induced nucleolar stress response and its deviation from DNA damage response pathways von Pigg, Hannah C., Alley, Katelyn R., Griffin, Christopher R., Moon, Caleb H., Kraske, Sarah J., DeRose, Victoria J.

“… ) and oxaliplatin utilizing a nucleolar stress–based cell death pathway. While cisplatin-induced DDR has been subject to much research, the mechanisms …”
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Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance von Johnson, Neil, Johnson, Shawn F, Yao, Wei, Li, Yu-Chen, Choi, Young-Eun, Bernhardy, Andrea J, Wang, Yifan, Capelletti, Marzia, Sarosiek, Kristopher A, Moreau, Lisa A, Chowdhury, Dipanjan, Wickramanayake, Anneka, Harrell, Maria I, Liu, Joyce F, D'Andrea, Alan D, Miron, Alexander, Swisher, Elizabeth M, Shapiro, Geoffrey I

“… ) domain of BRCA1 frequently create protein products unable to fold that are subject to protease-mediated degradation …”
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Relevance of Comet Assay and Phosphorylated-Hsp90α in Cancer Patients' Peripheral Blood Leukocytes as Tools to Assess Cisplatin-based Chemotherapy Clinical Response and Disease Outcome von Sottile, Mayra L, Gómez, Laura C, Redondo, Analía, Ibarra, Jorge, García, María B, Gonzalez, Lucía, Vargas-Roig, Laura M, Nadin, Silvina B

“… ) hr post-drug removal. Healthy subjects were also included. Baseline DNA damage was elevated in cancer patients …”
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Quantitative determination and subcellular mapping of Pt-based drugs in single breast tumour cells via laser ablation-ICP-mass spectrometry von Colina-Vegas, Legna, Van Acker, Thibaut, Villarreal, Wilmer, De Wever, Olivier, Batista, Alzir Azevedo, Nóbrega, Joaquim Araújo, Vanhaecke, Frank

“… ). Both compounds are essential in modern chemotherapy and continue to be the subject of research to optimize their therapeutic properties and minimize adverse effects …”
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Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity von Awuah, Samuel G, Riddell, Imogen A, Lippard, Stephen J

“… ). The hypersensitivity of TGCTs to cisplatin is a subject of widespread interest. Here, we show that high-mobility group box protein 4 (HMGB4 …”
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Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancer von Schuler, Patrick J, Harasymczuk, Malgorzata, Schilling, Bastian, Saze, Zenichiro, Strauss, Laura, Lang, Stephan, Johnson, Jonas T, Whiteside, Theresa L

“… ]. All treated subjects had no evident disease (NED) at the time of phlebotomy. In an additional cohort of 40 subjects with AD (n = 15), NED (n = 10), and NC (n = 15 …”
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The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours von Hannon Barroeta, Patricia, O’Sullivan, Maureen J., Zisterer, Daniela M.

“… The balance between oxidative stress mediated by reactive oxygen species (ROS) and the antioxidant system has become a subject of interest in cancer therapy research …”
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The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury von Mapuskar, Kranti A., Pulliam, Casey F., Tomanek-Chalkley, Ann, Rastogi, Prerna, Wen, Hsiang, Dayal, Sanjana, Griffin, Benjamin R., Zepeda-Orozco, Diana, Sindler, Amy L., Anderson, Carryn M., Beardsley, Robert, Kennedy, Eugene P., Spitz, Douglas R., Allen, Bryan G.

“… Cisplatin contributes to acute kidney injury (AKI) and chronic kidney disease (CKD) that occurs with greater frequency and severity in older patients …”
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Increased HRD score in cisplatin resistant penile cancer cells von Winkelmann, Ria, Bankov, Katrin, Döring, Claudia, Cinatl, Jaroslav, Grothe, Sebastian, Rothweiler, Florian, Michaelis, Martin, Schmitt, Christina, Wild, Peter J., Demes, Melanie, Cinatl, Jindrich, Vallo, Stefan

“… ) negative penile squamous cell carcinoma (UKF-PEC-1). This cell line was subject to chronic exposure to chemotherapy with CDDP and / or 5-FU to induce acquired resistance in the newly established chemo-resistant sublines …”
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Induction chemotherapy and concurrent chemoradiotherapy with cisplatin for T4 nasoethmoidal squamous cell carcinoma: The value of paclitaxel, carboplatin and cetuximab (PCE) von Tanaka, Nobukazu, Enokida, Tomohiro, Okano, Susumu, Fujisawa, Takao, Tanaka, Hideki, Onaga, Ryutaro, Hoshi, Yuta, Kishida, Takuma, Wada, Akihisa, Sato, Masanobu, Takeshita, Naohiro, Fujisawa, Takeshi, Motegi, Atsushi, Zenda, Sadamoto, Akimoto, Tetsuo, Tahara, Makoto

“… •The optimal therapy for locally advanced sinonasal SCC is still undetermined.•Induction chemotherapy in non-surgically-treated T4 sinonasal SCC was …”
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Ofranergene obadenovec (VB-111) in platinum-resistant ovarian cancer; favorable response rates in a phase I/II study are associated with an immunotherapeutic effect von Arend, Rebecca C., Beer, Hannah M., Cohen, Yael C., Berlin, Suzanne, Birrer, Michael J., Campos, Susana M., Rachmilewitz Minei, Tamar, Harats, Dror, Wall, Jaclyn A., Foxall, McKenzie E., Penson, Richard T.

“… Report final results of a phase I/II study of VB-111, a targeted anti-cancer gene therapy with a dual mechanism: anti angiogenic/vascular disruption and …”
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Protective Effect of Quercetin 3-O-Glucuronide against Cisplatin Cytotoxicity in Renal Tubular Cells von Muñoz-Reyes, Daniel, Casanova, Alfredo G., González-Paramás, Ana María, Martín, Ángel, Santos-Buelga, Celestino, Morales, Ana I., López-Hernández, Francisco J., Prieto, Marta

“… Quercetin, a flavonoid with promising therapeutic potential, has been shown to protect from cisplatin nephrotoxicity in rats following intraperitoneal …”
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Intratumoral STING activations overcome negative impact of cisplatin on antitumor immunity by inflaming tumor microenvironment in squamous cell carcinoma von Harabuchi, Shohei, Kosaka, Akemi, Yajima, Yuki, Nagata, Marino, Hayashi, Ryusuke, Kumai, Takumi, Ohara, Kenzo, Nagato, Toshihiro, Oikawa, Kensuke, Ohara, Mizuho, Harabuchi, Yasuaki, Ohkuri, Takayuki, Kobayashi, Hiroya

“… by comparing T-cell functions between human subjects treated and untreated with CDDP. The immune responses and the efficacy of combination therapy using CDDP and cGAMP …”
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Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1 von Wei, Wujun, Li, Jiaxing, Huang, Jingjing, Jiang, Qi, Lin, Cheng, Hu, Rentong, Wei, Jiazhu, Li, Qiao, Xu, Guidan, Chang, Zhengyi

“… Cisplatin (DDP) is a key chemotherapeutic agent in the treatment of gastric cancer; however, its efficacy is often limited by chemoresistance, a notable …”
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Sequence-dependent effects of hematoporphyrin derivatives (HPD) photodynamic therapy and cisplatin on lung adenocarcinoma cells von Li, Nana, Cui, Shichao, Yang, Aizhen, Xiao, Baohong, Cao, Yiwei, Yang, Xiaohui, Lin, Cunzhi

“… •The order of the combination therapy (PDT + DDP / DDP + PDT) was important.•The cell viability in the PDT+DDP (HPD-PDT followed by DDP) group was …”
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MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma von Bissey, Pierre-Antoine, Teng, Mona, Law, Jacqueline H., Shi, Wei, Bruce, Jeff P., Petit, Valentin, Tsao, Sai W., Yip, Kenneth W., Liu, Fei-Fei

“… Methods Two hundred forty-six NPC patient biopsy samples were subject to comprehensive miRNA profiling and immunohistochemistry (IHC …”
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Cross-linking of the DNA repair protein O 6 -alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin von Ming, Xun, Michaelson-Richie, Erin D, Groehler, 4th, Arnold S, Villalta, Peter W, Campbell, Colin, Tretyakova, Natalia Y

“… 1,1,2,2-cis-diamminedichloroplatinum (II) (cisplatin) is a chemotherapeutic agent widely used in the clinic to treat various cancers. The antitumor activity of …”
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The Role of Heat Shock Proteins in Cisplatin Resistance von Krawczyk, Zdzisław, Gogler-Pigłowska, Agnieszka, Sojka, Damian R, Scieglinska, Dorota

“… Cisplatin (CDDP), a small molecule platinum-based compound, is an effective anticancer drug used against a wide range of human neoplasms. Long-term clinical …”
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