Suchergebnisse - "Cipponi, Arcadi"

Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases von Cipponi, Arcadi, Mercier, Marjorie, Seremet, Teofila, Baurain, Jean-François, Théate, Ivan, van den Oord, Joost, Stas, Marguerite, Boon, Thierry, Coulie, Pierre G, van Baren, Nicolas

“… Lymphoid neogenesis, or the development of lymphoid structures in nonlymphoid organs, is frequently observed in chronically inflamed tissues, during the course …”
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MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer von Cipponi, Arcadi, Goode, David L, Bedo, Justin, McCabe, Mark J, Pajic, Marina, Croucher, David R, Rajal, Alvaro Gonzalez, Junankar, Simon R, Saunders, Darren N, Lobachevsky, Pavel, Papenfuss, Anthony T, Nessem, Danielle, Nobis, Max, Warren, Sean C, Timpson, Paul, Cowley, Mark, Vargas, Ana C, Qiu, Min R, Generali, Daniele G, Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M, Long, Georgina V, Blay, Jean-Yves, Thomas, David M

“… In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes …”
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Monogenic and polygenic determinants of sarcoma risk: an international genetic study von Ballinger, Mandy L, Goode, David L, Ray-Coquard, Isabelle, James, Paul A, Mitchell, Gillian, Niedermayr, Eveline, Puri, Ajay, Schiffman, Joshua D, Dite, Gillian S, Cipponi, Arcadi, Maki, Robert G, Brohl, Andrew S, Myklebost, Ola, Stratford, Eva W, Lorenz, Susanne, Ahn, Sung-Min, Ahn, Jin-Hee, Kim, Jeong Eun, Shanley, Sue, Beshay, Victoria, Randall, Robert Lor, Judson, Ian, Seddon, Beatrice, Campbell, Ian G, Young, Mary-Anne, Sarin, Rajiv, Blay, Jean-Yves, O'Donoghue, Seán I, Thomas, David M

“… Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately affect the young. Outside rare syndromes, the nature, extent, and clinical …”
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A universal molecular control for DNA, mRNA and protein expression von Gunter, Helen M., Youlten, Scott E., Reis, Andre L. M., McCubbin, Tim, Madala, Bindu Swapna, Wong, Ted, Stevanovski, Igor, Cipponi, Arcadi, Deveson, Ira W., Santini, Nadia S., Kummerfeld, Sarah, Croucher, Peter I., Marcellin, Esteban, Mercer, Tim R.

“… The expression of genes encompasses their transcription into mRNA followed by translation into protein. In recent years, next-generation sequencing and mass …”
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Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why? von Cipponi, Arcadi, Wieers, Grégoire, van Baren, Nicolas, Coulie, Pierre G.

“… Tumor-infiltrating T lymphocytes (TILs) are observed in a number of human primary or metastatic tumors. Recently, gene expression profiling experiments …”
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High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort von Mitchell, Gillian, Ballinger, Mandy L., Wong, Stephen, Hewitt, Chelsee, James, Paul, Young, Mary-Anne, Cipponi, Arcadi, Pang, Tiffany, Goode, David L., Dobrovic, Alex, Thomas, David M.

“… Sarcomas are a key feature of Li-Fraumeni and related syndromes (LFS/LFL), associated with germline TP53 mutations. Current penetrance estimates for TP53 …”
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Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity von Russo, Vincenzo, Cipponi, Arcadi, Raccosta, Laura, Rainelli, Cristina, Fontana, Raffaella, Maggioni, Daniela, Lunghi, Francesca, Mukenge, Sylvain, Ciceri, Fabio, Bregni, Marco, Bordignon, Claudio, Traversari, Catia

“… The exploitation of the physiologic processing and presenting machinery of DCs by in vivo loading of tumor-associated antigens may improve the immunogenic …”
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Expression of CXCR4, the receptor for stromal cell‐derived factor‐1 on fetal and adult human lymphohematopoietic progenitors von Aiuti, Alessandro, Tavian, Manuela, Cipponi, Arcadi, Ficara, Francesca, Zappone, Elisabetta, Hoxie, James, Peault, Bruno, Bordignon, Claudio

“… Stromal cell‐derived factor‐1 (SDF‐1) is a CXC chemokine produced by stromal cells that acts as a chemoattractant for human CD34+ progenitor cells. We …”
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Stress-induced cellular adaptive strategies: Ancient evolutionarily conserved programs as new anticancer therapeutic targets von Cipponi, Arcadi, Thomas, David M.

“… Despite the remarkable achievements of novel targeted anti‐cancer drugs, most therapies only produce remission for a limited time, resistance to treatment, and …”
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A quantitative model to predict pathogenicity of missense variants in the TP53 gene von Fortuno, Cristina, Cipponi, Arcadi, Ballinger, Mandy L., Tavtigian, Sean V., Olivier, Magali, Ruparel, Vatsal, Haupt, Ygal, Haupt, Sue, Study, International Sarcoma Kindred, Tucker, Kathy, Spurdle, Amanda B., Thomas, David M., James, Paul A.

“… Germline pathogenic variants in the TP53 gene cause Li‐Fraumeni syndrome, a condition that predisposes individuals to a wide range of cancer types …”
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Development and validation of a targeted gene sequencing panel for application to disparate cancers von McCabe, Mark J., Gauthier, Marie-Emilie A., Chan, Chia-Ling, Thompson, Tanya J., De Sousa, Sunita M.C., Puttick, Clare, Grady, John P., Gayevskiy, Velimir, Tao, Jiang, Ying, Kevin, Cipponi, Arcadi, Deng, Niantao, Swarbrick, Alex, Thomas, Melissa L., Lord, Reginald V., Johns, Amber L., Kohonen-Corish, Maija, O’Toole, Sandra A., Clark, Jonathan, Mueller, Simon A., Gupta, Ruta, McCormack, Ann I., Dinger, Marcel E., Cowley, Mark J.

“… Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a …”
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Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients von Fontana, Raffaella, Bregni, Marco, Cipponi, Arcadi, Raccosta, Laura, Rainelli, Cristina, Maggioni, Daniela, Lunghi, Francesca, Ciceri, Fabio, Mukenge, Sylvain, Doglioni, Claudio, Colau, Didier, Coulie, Pierre G, Bordignon, Claudio, Traversari, Catia, Russo, Vincenzo

“… Dendritic cell (DC) targeting in vivo has recently been shown to confer strong and protective cytotoxic T lymphocyte (CTL)-based immunity in tumor murine …”
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Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus von Aiuti, A, Turchetto, L, Cota, M, Cipponi, A, Brambilla, A, Arcelloni, C, Paroni, R, Vicenzi, E, Bordignon, C, Poli, G

“… Human CD34(+) hematopoietic progenitor cells obtained from bone marrow (BM), umbilical cord blood (UCB), and mobilized peripheral blood (MPB) were purified and …”
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Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion von Valentinis, Barbara, Bianchi, Alessandro, Zhou, Dan, Cipponi, Arcadi, Catalanotti, Federica, Russo, Vincenzo, Traversari, Catia

“… Polymyxin B is a lipopolysaccharide binding antibiotic used to inactivate potential lipopolysaccharide contaminations when evaluating the activity of different …”
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High-performance liquid chromatographic purification and capillary electrophoresis quantification of the chemokine stromal cell-derived factor-1 von Arcelloni, Cinzia, Aiuti, Alessandro, Cipponi, Arcadi, Paroni, Rita

“… Chemokines are members of the chemotactic cytokines family implicated in various immunoregulatory functions. The CXC–chemokine stromal cell derived factor-1 …”
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