Suchergebnisse - "Chu, Yaping"

Disease duration and the integrity of the nigrostriatal system in Parkinson's disease von Kordower, Jeffrey H, Olanow, C Warren, Dodiya, Hemraj B, Chu, Yaping, Beach, Thomas G, Adler, Charles H, Halliday, Glenda M, Bartus, Raymond T

“… The pace of nigrostriatal degeneration, both with regards to striatal denervation and loss of melanin and tyrosine hydroxylase-positive neurons, is poorly …”
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Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease von Kordower, Jeffrey H, Chu, Yaping, Hauser, Robert A, Freeman, Thomas B, Olanow, C Warren

“… Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body–like …”
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Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? von Chu, Yaping, Kordower, Jeffrey H.

“… α-Synuclein is a synaptic protein that has been directly linked to both the etiology and pathogenesis of Parkinson's disease. We have previously shown that …”
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GDNF signaling in subjects with minimal motor deficits and Parkinson's disease von Chu, Yaping, Kordower, Jeffrey H.

“… The failure of glial cell derived neurotropic factor to be efficacious in blinded clinical trials for Parkinson's disease may be due to alterations in …”
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Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease von Chu, Yaping, Morfini, Gerardo A, Langhamer, Lori B, He, Yinzhen, Brady, Scott T, Kordower, Jeffrey H

“… The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's disease. As terminal field loss seems to precede cell body loss, …”
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Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions von Chu, Yaping, Dodiya, Hemraj, Aebischer, Patrick, Olanow, C. Warren, Kordower, Jeffrey H.

“… We explored the relationship between ubiquitin proteasome system (UPS) and lysosomal markers and the formation of α-synuclein (α-syn) inclusions in nigral …”
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PGC−1α Promoter Methylation in Parkinson’s Disease von Su, Xiaomin, Chu, Yaping, Kordower, Jeffrey H., Li, Bin, Cao, Hong, Huang, Liang, Nishida, Maki, Song, Lei, Wang, Difei, Federoff, Howard J.

“… The etiopathogenesis of sporadic Parkinson's disease (PD) remains elusive although mitochondrial dysfunction has long been implicated. Recent evidence revealed …”
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Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders von Chu, Yaping, Harms, Ashley S., Boehringer, Ashley, Kordower, Jeffrey H.

“… Chronic neuroinflammation is a persistent feature of individuals with Parkinson's disease (PD). Dopaminergic neurodegeneration is partially associated with …”
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Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA von Becker, Katelyn, Wang, Xinhe, Vander Stel, Kayla, Chu, Yaping, Kordower, Jeffrey, Ma, Jiyan

“… Alpha synuclein (α-syn) is central to the pathogenesis of a group of neurodegenerative disorders known as synucleinopathies, including Parkinson’s disease …”
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Transplanted dopaminergic neurons develop PD pathologic changes: A second case report von Kordower, Jeffrey H., Chu, Yaping, Hauser, Robert A., Olanow, C.Warren, Freeman, Thomas B.

“… This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation …”
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A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease von Rafii, Michael S, Baumann, Tiffany L, Bakay, Roy A E, Ostrove, Jeffrey M, Siffert, Joao, Fleisher, Adam S, Herzog, Christopher D, Barba, David, Pay, Mary, Salmon, David P, Chu, Yaping, Kordower, Jeffrey H, Bishop, Kathie, Keator, David, Potkin, Steven, Bartus, Raymond T

“… Nerve growth factor (NGF) is an endogenous neurotrophic-factor protein with the potential to restore function and to protect degenerating cholinergic neurons …”
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Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease von Chu, Yaping, Goldman, Jennifer G., Kelly, Leo, He, Yinzhen, Waliczek, Tracy, Kordower, Jeffrey H.

“… Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship …”
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Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains von Bartus, Raymond T., Herzog, Christopher D., Chu, Yaping, Wilson, Alistair, Brown, Lamar, Siffert, Joao, Johnson Jr, Eugene M., Olanow, C. Warren, Mufson, Elliott J., Kordower, Jeffrey H.

“… Background: AAV2‐neurturin (CERE‐120) is designed to deliver the neurotrophic‐factor, neurturin, to the striatum to restore and protect degenerating …”
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Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease von Gatto, Rodolfo G, Chu, Yaping, Ye, Allen Q, Price, Steven D, Tavassoli, Ehsan, Buenaventura, Andrea, Brady, Scott T, Magin, Richard L, Kordower, Jeffrey H, Morfini, Gerardo A

“… Cumulative evidence indicates that the onset and severity of Huntington's disease (HD) symptoms correlate with connectivity deficits involving specific …”
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Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis von Killinger, Bryan A., Mercado, Gabriela, Choi, Solji, Tittle, Tyler, Chu, Yaping, Brundin, Patrik, Kordower, Jeffrey H.

“… Synucleinopathies are neurodegenerative diseases characterized by pathological inclusions called “Lewy pathology” (LP) that consist of aggregated …”
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Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease von Choi, Solji G., Tittle, Tyler R., Barot, Raj R., Betts, Dakota J., Gallagher, Johnie J., Kordower, Jeffrey H., Chu, Yaping, Killinger, Bryan A.

“… Synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are neurodegenerative diseases with …”
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Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity von Wahlberg, Lars U., Bintz, Briannan, Thanos, Chris, Chu, Yaping, Kordower, Jeffrey H., Emerich, Dwaine F., Paolone, Giovanna

“… Methods. Human ARPE-19 cells engineered to secrete high levels of the glial cell line-derived neurotrophic factor (GDNF) were encapsulated into hollow fiber …”
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Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer’s disease model mice and macaques von Zhou, Feng-Qin, Jiang, Juan, Griffith, Chelsea M., Patrylo, Peter R., Cai, Huaibin, Chu, Yaping, Yan, Xiao-Xin

“… Background Alzheimer’s disease (AD) is a devastating neurodegenerative disorder bearing multiple pathological hallmarks suggestive of complex …”
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Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups von Cai, Yan, Xiong, Kun, Chu, Yaping, Luo, Duan-Wu, Luo, Xue-Gang, Yuan, Xian-Yui, Struble, Robert G., Clough, Richard W., Spencer, Dennis D., Williamson, Anne, Kordower, Jeffrey H., Patrylo, Peter R., Yan, Xiao-Xin

“… DCX-immunoreactive (DCX+) cells occur in the piriform cortex in adult mice and rats, but also in the neocortex in adult guinea pigs and rabbits. Here we …”
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Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism von Collier, Timothy J., Lipton, Jack, Daley, Brian F., Palfi, Stephane, Chu, Yaping, Sortwell, Caryl, Bakay, Roy A.E., Sladek, John R., Kordower, Jeffrey H.

“… Aging is the most prominent risk factor for Parkinson’s disease. Yet, consensus of how advancing age may predispose the dopamine (DA) system to parkinsonism is …”
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