Suchergebnisse - "Chepyala, Divyabharathi"

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators von Nishiguchi, Gisele, Keramatnia, Fatemeh, Min, Jaeki, Chang, Yunchao, Jonchere, Barbara, Das, Sourav, Actis, Marisa, Price, Jeanine, Chepyala, Divyabharathi, Young, Brandon, McGowan, Kevin, Slavish, P Jake, Mayasundari, Anand, Jarusiewicz, Jamie A, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H, Papizan, James B, Kodali, Kiran, Peng, Junmin, Pruett Miller, Shondra M, Roussel, Martine F, Mullighan, Charles, Fischer, Marcus, Rankovic, Zoran

“… Whereas the PROTAC approach to target protein degradation greatly benefits from rational design, the discovery of small-molecule degraders relies mostly on …”
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Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia von Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A, Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J, Roberts, Kathryn G, Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S, Pruett-Miller, Shondra M, Paietta, Elisabeth M, Litzow, Mark R, Qu, Chunxu, Yang, Jun J, Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G

“… CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL and is associated with a …”
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The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia von Chang, Yunchao, Keramatnia, Fatemeh, Ghate, Pankaj S, Nishiguchi, Gisele, Gao, Qingsong, Iacobucci, Ilaria, Yang, Lei, Chepyala, Divyabharathi, Mishra, Ashutosh, High, Anthony A, Goto, Hiroaki, Akahane, Koshi, Peng, Junmin, Yang, Jun J, Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G

“… Advancing cure rates for high-risk acute lymphoblastic leukemia (ALL) has been limited by the lack of agents that effectively kill leukemic cells, sparing …”
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Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy von Zuckermann, Marc, He, Chen, Andrews, Jared, Bagchi, Aditi, Sloan-Henry, Roketa, Bianski, Brandon, Xie, Jia, Wang, Yingzhe, Twarog, Nathaniel, Onar-Thomas, Arzu, Ernst, Kati J., Yang, Lei, Li, Yong, Zhu, Xiaoyan, Ocasio, Jennifer K., Budd, Kaitlin M., Dalton, James, Li, Xiaoyu, Chepyala, Divyabharathi, Zhang, Junyuan, Xu, Ke, Hover, Laura, Roach, Jordan T., Chan, Kenneth Chun-Ho, Hofmann, Nina, McKinnon, Peter J., Pfister, Stefan M., Shelat, Anang A., Rankovic, Zoran, Freeman, Burgess B., Chiang, Jason, Jones, David T. W., Tinkle, Christopher L., Baker, Suzanne J.

“… Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple …”
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Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia von Hu, Jianzhong, Jarusiewicz, Jamie, Du, Guoqing, Nishiguchi, Gisele, Yoshimura, Satoshi, Panetta, John C, Li, Zhenhua, Min, Jaeki, Yang, Lei, Chepyala, Divyabharathi, Actis, Marisa, Reyes, Noemi, Smart, Brandon, Pui, Ching-Hon, Teachey, David T, Rankovic, Zoran, Yang, Jun J

“… T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and there is an unmet need for targeted therapies, especially for …”
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Using matrix-induced ion suppression combined with LC-MS/MS for quantification of trimethylamine-N-oxide, choline, carnitine and acetylcarnitine in dried blood spot samples von Lu, Wan-Hui, Chiu, Huai-Hsuan, Kuo, Han-Chun, Chen, Guan-Yuan, Chepyala, Divyabharathi, Kuo, Ching-Hua

“… Recently, there has been significant interest in the influences of the human gut microbiota on many diseases, such as cardiovascular disease (CVD) and …”
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Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations von Maillard, Maud, Nishii, Rina, Yang, Wenjian, Hoshitsuki, Keito, Chepyala, Divyabharathi, Lee, Shawn H R, Nguyen, Jenny Q, Relling, Mary V, Crews, Kristine R, Leggas, Mark, Singh, Meenu, Suang, Joshua L Y, Yeoh, Allen E J, Jeha, Sima, Inaba, Hiroto, Pui, Ching-Hon, Karol, Seth E, Trehan, Amita, Bhatia, Prateek, Antillon Klussmann, Federico G, Bhojwani, Deepa, Haidar, Cyrine E, Yang, Jun J

“… Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase …”
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POSTER: ALL-594 Preclinical Assessment of Dual FLT3 and BCL-2 Inhibition in Lineage Ambiguous Leukemia von Montefiori, Lindsey, Iacobucci, Ilaria, Budhraja, Amit, Moore, Jamila, Baskin-Doerfler, Rebekah, DeVries, Rebekah, Backhaus, Emily, Johnson, Melissa, Chepyala, Divyabharathi, Mehr, Cyrus, Mead, Paul, Opferman, Joseph, Mullighan, Charles

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ALL-594 Preclinical Assessment of Dual FLT3 and BCL-2 Inhibition in Lineage Ambiguous Leukemia von Montefiori, Lindsey, Iacobucci, Ilaria, Budhraja, Amit, Moore, Jamila, Baskin-Doerfler, Rebekah, DeVries, Rebekah, Backhaus, Emily, Johnson, Melissa, Chepyala, Divyabharathi, Mehr, Cyrus, Mead, Paul, Opferman, Joseph, Mullighan, Charles

“… Lineage ambiguous leukemias pose diagnostic and treatment challenges and have historically poor outcomes. The BCL11B-activated (“BCL11B-a”) subtype of lineage …”
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Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method von Chepyala, Divyabharathi, Kuo, Han-Chun, Su, Kang-Yi, Liao, Hsiao-Wei, Wang, San-Yuan, Chepyala, Surendhar Reddy, Chang, Lin-Chau, Kuo, Ching-Hua

“… Dried blood spots (DBSs) have gained increasing attention recently with their growing importance in precision medicine. DBS-based metabolomics analysis …”
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Development and validation of a high-performance liquid chromatography-fluorescence detection method for the accurate quantification of colistin in human plasma von Chepyala, Divyabharathi, Tsai, I-Lin, Sun, Hsin-Yun, Lin, Shu-Wen, Kuo, Ching-Hua

“… •A HPLC-FLD method was developed for colistin quantification in human plasma.•In-SPE derivatization method was applied for plasma sample preparation.•The …”
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Sensitive screening of abused drugs in dried blood samples using ultra-high-performance liquid chromatography-ion booster-quadrupole time-of-flight mass spectrometry von Chepyala, Divyabharathi, Tsai, I-Lin, Liao, Hsiao-Wei, Chen, Guan-Yuan, Chao, Hsi-Chun, Kuo, Ching-Hua

“… •An efficient UHPLC-IB-QTOF-MS method was developed to screen 57 abused drugs on DBS samples.•IB source with an extra heated spray zone provides sensitive …”
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Poster: ALL-090 Highly Effective Combination of FLT3 and BCL2 Inhibitors in a Preclinical Model of Lineage Ambiguous Leukemia von Montefiori, Lindsey, Iacobucci, Ilaria, Budhraja, Amit, Moore, Jamila, Baskin, Rebekah, DeVries, Rebekah, Backhaus, Emily, Johnson, Melissa, Akers, Walter, Chepyala, Divyabharathi, Mehr, Cyrus, Seth, Aman, Mead, Paul, Opferman, Joseph, Mullighan, Charles

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ALL-090 Highly Effective Combination of FLT3 and BCL2 Inhibitors in a Preclinical Model of Lineage Ambiguous Leukemia von Montefiori, Lindsey, lacobucci, Ilaria, Budhraja, Amit, Moore, Jamila, Baskin, Rebekah, DeVries, Rebekah, Backhaus, Emily, Johnson, Melissa, Akers, Walter, Chepyala, Divyabharathi, Mehr, Cyrus, Seth, Aman, Mead, Paul, Opferman, Joseph, Mullighan, Charles

“… Context: Lineage ambiguous leukemias are rare leukemia subtypes with diagnostic and treatment challenges and poor outcomes. We recently described a new subtype …”
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An on-spot internal standard addition approach for accurately determining colistin A and colistin B in dried blood spots using ultra high-performance liquid chromatography–tandem mass spectrometry von Tsai, I-Lin, Kuo, Ching-Hua, Sun, Hsin-Yun, Chuang, Yu-Chung, Chepyala, Divyabharathi, Lin, Shu-Wen, Tsai, Yun-Jung

“… [Display omitted] •A stable and accurate method was developed for colistin quantification from DBS.•On-spot internal standard addition was applied for accurate …”
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