Suchergebnisse - "Chauhan, Jagat"

GlycoPP: A Webserver for Prediction of N- and O-Glycosites in Prokaryotic Protein Sequences von Chauhan, Jagat S., Bhat, Adil H., Raghava, Gajendra P. S., Rao, Alka

“… Glycosylation is one of the most abundant post-translational modifications (PTMs) required for various structure/function modulations of proteins in a living …”
Volltext

An in silico platform for predicting, screening and designing of antihypertensive peptides von Kumar, Ravi, Chaudhary, Kumardeep, Singh Chauhan, Jagat, Nagpal, Gandharva, Kumar, Rahul, Sharma, Minakshi, Raghava, Gajendra P.S.

“… High blood pressure or hypertension is an affliction that threatens millions of lives worldwide. Peptides from natural origin have been shown recently to be …”
Volltext

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity von Vivas-García, Yurena, Falletta, Paola, Liebing, Jana, Louphrasitthiphol, Pakavarin, Feng, Yongmei, Chauhan, Jagat, Scott, David A, Glodde, Nicole, Chocarro-Calvo, Ana, Bonham, Sarah, Osterman, Andrei L, Fischer, Roman, Ronai, Ze'ev, García-Jiménez, Custodia, Hölzel, Michael, Goding, Colin R

“… Phenotypic and metabolic heterogeneity within tumors is a major barrier to effective cancer therapy. How metabolism is implicated in specific phenotypes and …”
Weitere Angaben

Identification of ATP binding residues of a protein from its primary sequence von Chauhan, Jagat S, Mishra, Nitish K, Raghava, Gajendra PS

“… Background One of the major challenges in post-genomic era is to provide functional annotations for large number of proteins arising from genome sequencing …”
Volltext

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma von Falletta, Paola, Sanchez-Del-Campo, Luis, Chauhan, Jagat, Effern, Maike, Kenyon, Amy, Kershaw, Christopher J, Siddaway, Robert, Lisle, Richard, Freter, Rasmus, Daniels, Matthew J, Lu, Xin, Tüting, Thomas, Middleton, Mark, Buffa, Francesca M, Willis, Anne E, Pavitt, Graham, Ronai, Ze'ev A, Sauka-Spengler, Tatjana, Hölzel, Michael, Goding, Colin R

“… The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and …”
Weitere Angaben

The MITF regulatory network in melanoma von Chauhan, Jagat S., Hölzel, Michael, Lambert, Jean‐Philippe, Buffa, Francesca M., Goding, Colin R.

“… Bidirectional interactions between plastic tumor cells and the microenvironment critically impact tumor evolution and metastatic dissemination by enabling …”
Volltext

MITF controls the TCA cycle to modulate the melanoma hypoxia response von Louphrasitthiphol, Pakavarin, Ledaki, Ioanna, Chauhan, Jagat, Falletta, Paola, Siddaway, Robert, Buffa, Francesca M., Mole, David R., Soga, Tomoyoshi, Goding, Colin R.

“… In response to the dynamic intra‐tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the …”
Volltext

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73 von Papaspyropoulos, Angelos, Bradley, Leanne, Thapa, Asmita, Leung, Chuen Yan, Toskas, Konstantinos, Koennig, Delia, Pefani, Dafni-Eleftheria, Raso, Cinzia, Grou, Claudia, Hamilton, Garth, Vlahov, Nikola, Grawenda, Anna, Haider, Syed, Chauhan, Jagat, Buti, Ludovico, Kanapin, Alexander, Lu, Xin, Buffa, Francesca, Dianov, Grigory, von Kriegsheim, Alex, Matallanas, David, Samsonova, Anastasia, Zernicka-Goetz, Magdalena, O’Neill, Eric

“… Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a …”
Volltext

TBX2 controls a proproliferative gene expression program in melanoma von Lu, Sizhu, Louphrasitthiphol, Pakavarin, Goradia, Nishit, Lambert, Jean-Philippe, Schmidt, Johannes, Chauhan, Jagat, Rughani, Milap G, Larue, Lionel, Wilmanns, Matthias, Goding, Colin R

“… Senescence shapes embryonic development, plays a key role in aging, and is a critical barrier to cancer initiation, yet how senescence is regulated remains …”
Weitere Angaben

Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State von Carena, Maria Cristina, Badi, Ileana, Polkinghorne, Murray, Akoumianakis, Ioannis, Psarros, Costas, Wahome, Elizabeth, Kotanidis, Christos P, Akawi, Nadia, Antonopoulos, Alexios S, Chauhan, Jagat, Sayeed, Rana, Krasopoulos, George, Srivastava, Vivek, Farid, Shakil, Walcot, Nicholas, Douglas, Gillian, Channon, Keith M, Casadei, Barbara, Antoniades, Charalambos

“… Visceral obesity is directly linked to increased cardiovascular risk, including heart failure. This study explored the ability of human epicardial adipose …”
Weitere Angaben

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer von Gutiérrez-Salmerón, María, García-Martínez, José Manuel, Martínez-Useros, Javier, Fernández-Aceñero, María Jesús, Viollet, Benoit, Olivier, Severine, Chauhan, Jagat, Lucena, Silvia R., De la Vieja, Antonio, Goding, Colin R., Chocarro-Calvo, Ana, García-Jiménez, Custodia

“… Coordination of gene expression with nutrient availability supports proliferation and homeostasis and is shaped by protein acetylation. Yet how …”
Volltext

Prediction of GTP interacting residues, dipeptides and tripeptides in a protein from its evolutionary information von Chauhan, Jagat S, Mishra, Nitish K, Raghava, Gajendra PS

“… Background Guanosine triphosphate (GTP)-binding proteins play an important role in regulation of G-protein. Thus prediction of GTP interacting residues in a …”
Volltext

In silico Platform for Prediction of N-, O- and C-Glycosites in Eukaryotic Protein Sequences von Chauhan, Jagat Singh, Rao, Alka, Raghava, Gajendra P. S.

“… Glycosylation is one of the most abundant and an important post-translational modification of proteins. Glycosylated proteins (glycoproteins) are involved in …”
Volltext

In Silico Designing and Screening of Antagonists against Cancer Drug Target XIAP von Kumar, Rahul, Chauhan, Jagat Singh, Raghava, Gajendra Pal Singh

“… X-linked inhibitor of apoptosis (XIAP) is a member of inhibitor of apoptosis (IAP) family and involved in the suppression of apoptosis in cancer cells. This …”
Weitere Angaben

Prospects of Aloe vera and its Bioactive Compounds in Diabetes: Critical Review von Sharma, Mukesh Kumar, Chauhan, Jagat, Kumar, Mohan, Joshi, Chetan Kumar, Sharma, Sandeep, Lal, Chhagan

“… Diabetes is a significant public health issue. The global diabetes epidemic has had a tremendous impact on India, and the disease burden has increased …”
Volltext

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF von Fane, Mitchell E., Chhabra, Yash, Hollingsworth, David E.J., Simmons, Jacinta L., Spoerri, Loredana, Oh, Tae Gyu, Chauhan, Jagat, Chin, Toby, Harris, Lachlan, Harvey, Tracey J., Muscat, George E.O., Goding, Colin R., Sturm, Richard A, Haass, Nikolas K., Boyle, Glen M., Piper, Michael, Smith, Aaron G.

“… While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain …”
Volltext

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression von Kalkavan, Halime, Sharma, Piyush, Kasper, Stefan, Helfrich, Iris, Pandyra, Aleksandra A., Gassa, Asmae, Virchow, Isabel, Flatz, Lukas, Brandenburg, Tim, Namineni, Sukumar, Heikenwalder, Mathias, Höchst, Bastian, Knolle, Percy A., Wollmann, Guido, von Laer, Dorothee, Drexler, Ingo, Rathbun, Jessica, Cannon, Paula M., Scheu, Stefanie, Bauer, Jens, Chauhan, Jagat, Häussinger, Dieter, Willimsky, Gerald, Löhning, Max, Schadendorf, Dirk, Brandau, Sven, Schuler, Martin, Lang, Philipp A., Lang, Karl S.

“… Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour …”
Volltext

Analysis and prediction of cancerlectins using evolutionary and domain information von Kumar, Ravi, Panwar, Bharat, Chauhan, Jagat S, Raghava, Gajendra PS

“… Background Predicting the function of a protein is one of the major challenges in the post-genomic era where a large number of protein sequences of unknown …”
Volltext

ProGlycProt: a repository of experimentally characterized prokaryotic glycoproteins von Bhat, Aadil H., Mondal, Homchoru, Chauhan, Jagat S., Raghava, Gajendra P. S., Methi, Amrish, Rao, Alka

“… ProGlycProt (http://www.proglycprot.org/) is an open access, manually curated, comprehensive repository of bacterial and archaeal glycoproteins with at least …”
Volltext

QSAR-Based Models for Designing Quinazoline/Imidazothiazoles/Pyrazolopyrimidines Based Inhibitors against Wild and Mutant EGFR von Chauhan, Jagat Singh, Dhanda, Sandeep Kumar, Singla, Deepak, Agarwal, Subhash M., Raghava, Gajendra P. S.

“… Overexpression of EGFR is responsible for causing a number of cancers, including lung cancer as it activates various downstream signaling pathways. Thus, it is …”
Volltext