Suchergebnisse - "Chard, Declan T"

Clinically isolated syndromes von Miller, David H, Chard, Declan T, Ciccarelli, Olga

“… Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with features suggestive of multiple sclerosis (MS). It usually occurs in …”
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A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes von Chung, Karen K., Altmann, Daniel, Barkhof, Frederik, Miszkiel, Katherine, Brex, Peter A., O'Riordan, Jonathan, Ebner, Michael, Prados, Ferran, Cardoso, M. Jorge, Vercauteren, Tom, Ourselin, Sebastien, Thompson, Alan, Ciccarelli, Olga, Chard, Declan T.

“… Objective Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early …”
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Cortical involvement determines impairment 30 years after a clinically isolated syndrome von Haider, Lukas, Prados, Ferran, Chung, Karen, Goodkin, Olivia, Kanber, Baris, Sudre, Carole, Yiannakas, Marios, Samson, Rebecca S, Mangesius, Stephanie, Thompson, Alan J, Gandini Wheeler-Kingshott, Claudia A M, Ciccarelli, Olga, Chard, Declan T, Barkhof, Frederik

“… Many studies report an overlap of MRI and clinical findings between patients with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive …”
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Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes von Chard, Declan T., Jackson, Jonathan S., Miller, David H., Wheeler-Kingshott, Claudia A.M.

“… Purpose: To develop an automated lesion‐filling technique (LEAP; LEsion Automated Preprocessing) that would reduce lesion‐associated brain tissue segmentation …”
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Gray matter atrophy is related to long-term disability in multiple sclerosis von Fisniku, Leonora K., Chard, Declan T., Jackson, Jonathan S., Anderson, Valerie M., Altmann, Daniel R., Miszkiel, Katherine A., Thompson, Alan J., Miller, David H.

“… Objective To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first …”
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Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis von Liu, Zheng, Pardini, Matteo, Yaldizli, Özgür, Sethi, Varun, Muhlert, Nils, Wheeler-Kingshott, Claudia A M, Samson, Rebecca S, Miller, David H, Chard, Declan T

“… In multiple sclerosis, there is increasing evidence that demyelination, and neuronal damage occurs preferentially in cortical grey matter next to the outer …”
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SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis von Wottschel, Viktor, Chard, Declan T., Enzinger, Christian, Filippi, Massimo, Frederiksen, Jette L., Gasperini, Claudio, Giorgio, Antonio, Rocca, Maria A., Rovira, Alex, De Stefano, Nicola, Tintoré, Mar, Alexander, Daniel C., Barkhof, Frederik, Ciccarelli, Olga

“… •RFE-SVMs predict future outcome of CIS patients with conservative accuracy estimates between 64.9% and 88.1%.•Recursive feature selection improves …”
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Diagnosing Multiple Sclerosis: An Imperfect but Evolving Process von Chard, Declan T

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Normal cerebral perfusion measurements using arterial spin labeling: Reproducibility, stability, and age and gender effects von Parkes, Laura M., Rashid, Waqar, Chard, Declan T., Tofts, Paul S.

“… Before meaningful conclusions can be drawn from clinical measures of cerebral blood perfusion, the precision of the measurement must be determined and set in …”
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Chronically Active Lesions as a Trial Outcome in Multiple Sclerosis: A New Perspective on an Old Foe von Chard, Declan T

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MS Cortical Lesions on DIR: Not Quite What They Seem? von Sethi, Varun, Muhlert, Nils, Ron, Maria, Golay, Xavier, Wheeler-Kingshott, Claudia A., Miller, David H., Chard, Declan T., Yousry, Tarek A.

“… Accurate identification and localization of cortical gray matter (CGM) lesions in MS is important when determining their clinical relevance. Double inversion …”
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To halt disease progression rehabilitation in MS should start early: No von Chard, Declan T

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Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent von McMurran, Christopher E., Mukherjee, Trisha, Brown, J William L., Michell, Andrew W., Chard, Declan T., Franklin, Robin J. M., Coles, Alasdair J., Cunniffe, Nick G.

“… Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that …”
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Clinical commentary on 'Cortical ischemic lesions from atrial myxoma as a mimic of disease activity in a RRMS antiCD20-treated patient' von Chard, Declan T

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Spatial patterns of brain lesions assessed through covariance estimations of lesional voxels in multiple Sclerosis: The SPACE-MS technique von Tur, Carmen, Grussu, Francesco, De Angelis, Floriana, Prados, Ferran, Kanber, Baris, Calvi, Alberto, Eshaghi, Arman, Charalambous, Thalis, Cortese, Rosa, Chard, Declan T., Chataway, Jeremy, Thompson, Alan J., Ciccarelli, Olga, Gandini Wheeler-Kingshott, Claudia A.M.

“… [Display omitted] •We present SPACE-MS, a tool to assess the spatial distribution of brain lesions.•SPACE-MS metrics mainly reflect caudality and spatial …”
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Surface-in pathology in multiple sclerosis: a new view on pathogenesis? von Pardini, Matteo, Brown, J William L, Magliozzi, Roberta, Reynolds, Richard, Chard, Declan T

“… While multiple sclerosis can affect any part of the CNS, it does not do so evenly. In white matter it has long been recognized that lesions tend to occur …”
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An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression von Ananthavarathan, Piriyankan, Sahi, Nitin, Chard, Declan T

“… While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity in multiple sclerosis (MS), its utility in predicting and …”
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Unlocking Multiple Sclerosis Genetics: From Susceptibility to Severity von Sahi, Nitin, Ciccarelli, Olga, Houlden, Henry, Chard, Declan T

“… Multiple sclerosis (MS) is a clinically diverse and unpredictable CNS disorder. The considerable heterogeneity in disease course between people with MS is …”
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Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis von Calvi, Alberto, Carrasco, Ferran Prados, Tur, Carmen, Chard, Declan T, Stutters, Jonathan, De Angelis, Floriana, John, Nevin, Williams, Thomas, Doshi, Anisha, Samson, Rebecca S, MacManus, David, Gandini Wheeler-Kingshott, Claudia A, Ciccarelli, Olga, Chataway, Jeremy, Barkhof, Frederik

“… To explore the relationship between slowly expanding lesions (SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS). We …”
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Commentary on Al Hussona et al. 'New-onset seizures as a sole clinical presentation of multiple sclerosis' von Chard, Declan T

“… Despite the now significant contribution of magnetic resonance imaging, the accurate and timely diagnosis of multiple sclerosis (MS) is still clinically …”
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