Suchergebnisse - "Chapuis, Aude G"

Immunotherapy for skin cancer von Paulson, Kelly G, Lahman, Miranda C, Chapuis, Aude G, Brownell, Isaac

“… Among all tumor types, skin cancers are profoundly sensitive to immunotherapy. Indeed, the recently reported response rates for anti-PD-1 …”
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γ-Secretase inhibitor in combination with BCMA chimeric antigen receptor T-cell immunotherapy for individuals with relapsed or refractory multiple myeloma: a phase 1, first-in-human trial von Cowan, Andrew J, Pont, Margot J, Sather, Blythe D, Turtle, Cameron J, Till, Brian G, Libby, Edward N, Coffey, David G, Tuazon, Sherilyn A, Wood, Brent, Gooley, Ted, Wu, Vicky Q, Voutsinas, Jenna, Song, Xiaoling, Shadman, Mazyar, Gauthier, Jordan, Chapuis, Aude G, Milano, Filippo, Maloney, David G, Riddell, Stanley R, Green, Damian J

“… γ-Secretase inhibitors (GSIs) increase B cell maturation antigen (BCMA) density on malignant plasma cells and enhance antitumour activity of BCMA chimeric …”
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Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient von Chapuis, Aude G, Lee, Sylvia M, Thompson, John A, Roberts, Ilana M, Margolin, Kim A, Bhatia, Shailender, Sloan, Heather L, Lai, Ivy, Wagener, Felecia, Shibuya, Kendall, Cao, Jianhong, Wolchok, Jedd D, Greenberg, Philip D, Yee, Cassian

“… Adoptive transfer of peripheral blood-derived, melanoma-reactive CD8(+) cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky …”
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Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype von Chapuis, Aude G, Thompson, John A, Margolin, Kim A, Rodmyre, Rebecca, Lai, Ivy P, Dowdy, Kaye, Farrar, Erik A, Bhatia, Shailender, Sabath, Daniel E, Cao, Jianhong, Li, Yongqing, Yee, Cassian

“… Adoptively transferred tumor-specific T cells offer the potential for non-cross-resistant therapy and long-term immunoprotection. Strategies to enhance in vivo …”
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A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence von Mazziotta, Francesco, Martin, Lauren E., Egan, Daniel N., Bar, Merav, Kinsella, Sinéad, Paulson, Kelly G., Voillet, Valentin, Lahman, Miranda C., Hunter, Daniel, Schmitt, Thomas M., Duerkopp, Natalie, Yeung, Cecilia C. S., Tang, Tzu-Hao, Gottardo, Raphael, Asano, Yuta, Wilcox, Elise C., Lee, Bo, Zhang, Tianzi, Lopedote, Paolo, Penter, Livius, Wu, Catherine J., Milano, Filippo, Greenberg, Philip D., Chapuis, Aude G.

“… Relapsed and/or refractory acute myeloid leukemia (AML) post-allogeneic hematopoietic cell transplantation (HCT) is usually fatal. We previously reported that …”
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Real-world comparison of lisocabtagene maraleucel and axicabtagene ciloleucel in large B-cell lymphoma: an inverse probability of treatment weighting analysis with 3-year follow up von Portuguese, Andrew J., Huang, Jennifer J., Jeon, Yein, Taheri, Mahnoosh, Albittar, Aya, Liang, Emily C., Hirayama, Alexandre V., Kimble, Erik L., Iovino, Lorenzo, Poh, Christina, Gopal, Ajay K., Shadman, Mazyar, Till, Brian G., Milano, Filippo, Chapuis, Aude G., Otegbeye, Folashade, Cassaday, Ryan D., Basom, Ryan S., Wu, Qian Vicky, Maloney, David G., Gauthier, Jordan

“… Lisocabtagene maraleucel (liso-cel) and axicabtagene ciloleucel (axi-cel) are FDA- and EMAapproved chimeric antigen receptor (CAR) T-cell therapies for …”
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An In Vivo Model of Human Macrophages in Metastatic Melanoma von Voillet, Valentin, Berger, Trisha R, McKenna, Kelly M, Paulson, Kelly G, Tan, Wei Hong, Smythe, Kimberly S, Hunter, Daniel S, Valente, William J, Weaver, Stephanie, Campbell, Jean S, Kim, Teresa S, Byrd, David R, Bielas, Jason H, Pierce, Robert H, Chapuis, Aude G, Gottardo, Raphaël, Rongvaux, Anthony

“… Despite recent therapeutic progress, advanced melanoma remains lethal for many patients. The composition of the immune tumor microenvironment (TME) has …”
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Enhancing immunogenic responses through CDK4/6 and HIF2α inhibition in Merkel cell carcinoma von Lee, Jung Hyun, Lee, Justin Daho, Paulson, Kelly, Voillet, Valentin, Berndt, Andre, Church, Candice, Lachance, Kristina, Park, Song Y., Yamamoto, Naomi K., Cromwell, Elizabeth A., Gottardo, Raphael, Chapuis, Aude G., Nghiem, Paul

“… Approximately 50% of Merkel cell carcinoma (MCC) patients facing this highly aggressive skin cancer initially respond positively to PD-1-based immunotherapy …”
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MR1-restricted T cell clonotypes are associated with “resistance” to Mycobacterium tuberculosis infection von Cross, Deborah L., Layton, Erik D., Yu, Krystle K.Q., Smith, Malisa T., Aguilar, Melissa S., Li, Shamin, Wilcox, Elise C., Chapuis, Aude G., Mayanja-Kizza, Harriet, Stein, Catherine M., Boom, W. Henry, Hawn, Thomas R., Bradley, Philip, Newell, Evan W., Seshadri, Chetan

“… T cells are required for protective immunity against Mycobacterium tuberculosis. We recently described a cohort of Ugandan household contacts of tuberculosis …”
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Expansion of the HSV-2–specific T cell repertoire in skin after immunotherapeutic HSV-2 vaccine von Ford, Emily S., Li, Alvason Z., Laing, Kerry J., Dong, Lichun, Diem, Kurt, Jing, Lichen, Mayer-Blackwell, Koshlan, Basu, Krithi, Ott, Mariliis, Tartaglia, Jim, Gurunathan, Sanjay, Reid, Jack L., Ecsedi, Matyas, Chapuis, Aude G., Huang, Meei-Li, Magaret, Amalia S., Johnston, Christine, Zhu, Jia, Koelle, David M., Corey, Lawrence

“… The skin at the site of HSV-2 reactivation is enriched for HSV-2-specific T cells. To evaluate whether an immunotherapeutic vaccine could elicit skin-based …”
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Development and validation of predictive models of early immune effector cell–associated hematotoxicity von Liang, Emily C., Huang, Jennifer J., Portuguese, Andrew J., Ortiz-Maldonado, Valentín, Albittar, Aya, Wuliji, Natalie, Basom, Ryan, Jeon, Yein, Wu, Qian, Torkelson, Aiko, Kirchmeier, Delaney, Chutnik, Abigail, Pender, Barbara, Sorror, Mohamed, Hill, Joshua A., Kopmar, Noam E., Banerjee, Rahul, Cowan, Andrew J., Green, Damian, Gopal, Ajay K., Poh, Christina, Shadman, Mazyar, Hirayama, Alexandre V., Till, Brian G., Kimble, Erik L., Iovino, Lorenzo, Chapuis, Aude G., Otegbeye, Folashade, Cassaday, Ryan D., Milano, Filippo, Turtle, Cameron J., Maloney, David G., Gauthier, Jordan

“… •Disease type, baseline cytopenia, lymphodepletion intensity, and systemic inflammation were strongly associated with severe eICAHT.•We validated 2 prediction …”
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Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics von Paulson, Kelly G., Park, Song Youn, Vandeven, Natalie A., Lachance, Kristina, Thomas, Hannah, Chapuis, Aude G., Harms, Kelly L., Thompson, John A., Bhatia, Shailender, Stang, Andreas, Nghiem, Paul

“… Merkel cell carcinoma (MCC) incidence rates are rising and strongly age-associated, relevant for an aging population. Determine MCC incidence in the United …”
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Age-Specific Incidence of Melanoma in the United States von Paulson, Kelly G, Gupta, Deepti, Kim, Teresa S, Veatch, Joshua R, Byrd, David R, Bhatia, Shailender, Wojcik, Katherine, Chapuis, Aude G, Thompson, John A, Madeleine, Margaret M, Gardner, Jennifer M

“… Melanoma is epidemiologically linked to UV exposure, particularly childhood sunburn. Public health campaigns are increasing sun-protective behavior in the …”
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Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy von Hay, Kevin A, Gauthier, Jordan, Hirayama, Alexandre V, Voutsinas, Jenna M, Wu, Qian, Li, Daniel, Gooley, Ted A, Cherian, Sindhu, Chen, Xueyan, Pender, Barbara S, Hawkins, Reed M, Vakil, Aesha, Steinmetz, Rachel N, Schoch, Gary, Chapuis, Aude G, Till, Brian G, Kiem, Hans-Peter, Ramos, Jorge D, Shadman, Mazyar, Cassaday, Ryan D, Acharya, Utkarsh H, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J

“… Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease-negative …”
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Genome Editing in Engineered T Cells for Cancer Immunotherapy von Bonini, Chiara, Chapuis, Aude G, Hudecek, Michael, Guedan, Sonia, Magnani, Chiara, Qasim, Waseem

“… Advanced gene transfer technologies and profound immunological insights have enabled substantial increases in the efficacy of anticancer adoptive cellular …”
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T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant von Chapuis, Aude G, Egan, Daniel N, Bar, Merav, Schmitt, Thomas M, McAfee, Megan S, Paulson, Kelly G, Voillet, Valentin, Gottardo, Raphael, Ragnarsson, Gunnar B, Bleakley, Marie, Yeung, Cecilia C, Muhlhauser, Petri, Nguyen, Hieu N, Kropp, Lara A, Castelli, Luca, Wagener, Felecia, Hunter, Daniel, Lindberg, Marcus, Cohen, Kristen, Seese, Aaron, McElrath, M Juliana, Duerkopp, Natalie, Gooley, Ted A, Greenberg, Philip D

“… Relapse after allogeneic hematopoietic cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) entering HCT with …”
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The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells von Hirayama, Alexandre V, Gauthier, Jordan, Hay, Kevin A, Voutsinas, Jenna M, Wu, Qian, Gooley, Ted, Li, Daniel, Cherian, Sindhu, Chen, Xueyan, Pender, Barbara S, Hawkins, Reed M, Vakil, Aesha, Steinmetz, Rachel N, Acharya, Utkarsh H, Cassaday, Ryan D, Chapuis, Aude G, Dhawale, Tejaswini M, Hendrie, Paul C, Kiem, Hans-Peter, Lynch, Ryan C, Ramos, Jorge, Shadman, Mazyar, Till, Brian G, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J

“… Factors associated with durable remission after CD19 chimeric antigen receptor (CAR)-modified T-cell immunotherapy for aggressive B-cell non-Hodgkin lymphoma …”
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Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies von Gauthier, Jordan, Bezerra, Evandro D, Hirayama, Alexandre V, Fiorenza, Salvatore, Sheih, Alyssa, Chou, Cassie K, Kimble, Erik L, Pender, Barbara S, Hawkins, Reed M, Vakil, Aesha, Phi, Tinh-Doan, Steinmetz, Rachel N, Jamieson, Abby W, Bar, Merav, Cassaday, Ryan D, Chapuis, Aude G, Cowan, Andrew J, Green, Damian J, Kiem, Hans-Peter, Milano, Filippo, Shadman, Mazyar, Till, Brian G, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J

“… CD19-targeted chimeric antigen receptor-engineered (CD19 CAR) T-cell therapy has shown significant efficacy for relapsed or refractory (R/R) B-cell …”
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Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo von Chapuis, Aude G., Paolo Rizzardi, G., D'Agostino, Claudia, Attinger, Antoine, Knabenhans, Christian, Fleury, Sylvain, Acha-Orbea, Hans, Pantaleo, Giuseppe

“… Mycophenolic acid, a selective inhibitor of the de novo synthesis of guanosine nucleotides in T and B lymphocytes, has been proposed to inhibit human …”
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A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia von Oda, Shannon K, Daman, Andrew W, Garcia, Nicolas M, Wagener, Felecia, Schmitt, Thomas M, Tan, Xiaoxia, Chapuis, Aude G, Greenberg, Philip D

“… Acute myeloid leukemia (AML), the most common adult acute leukemia in the United States, has the poorest survival rate, with 26% of patients surviving 5 years …”
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