Suchergebnisse - "Chandra, Tamir"

Epigenetic age prediction von Simpson, Daniel J., Chandra, Tamir

“… Advanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more is known about the molecular basis of any of …”
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Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity von Olova, Nelly, Simpson, Daniel J., Marioni, Riccardo E., Chandra, Tamir

“… Induced pluripotent stem cells (IPSCs), with their unlimited regenerative capacity, carry the promise for tissue replacement to counter age‐related decline …”
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Functional heterogeneity in senescence von Kirschner, Kristina, Rattanavirotkul, Nattaphong, Quince, Megan F, Chandra, Tamir

“… Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to …”
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Cellular reprogramming and epigenetic rejuvenation von Simpson, Daniel J., Olova, Nelly N., Chandra, Tamir

“… Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered …”
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Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease von Conway, Bryan R, O'Sullivan, Eoin D, Cairns, Carolynn, O'Sullivan, James, Simpson, Daniel J, Salzano, Angela, Connor, Katie, Ding, Peng, Humphries, Duncan, Stewart, Kevin, Teenan, Oliver, Pius, Riinu, Henderson, Neil C, Bénézech, Cécile, Ramachandran, Prakash, Ferenbach, David, Hughes, Jeremy, Chandra, Tamir, Denby, Laura

“… Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells …”
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Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation von Mohammed, Hisham, Hernando-Herraez, Irene, Savino, Aurora, Scialdone, Antonio, Macaulay, Iain, Mulas, Carla, Chandra, Tamir, Voet, Thierry, Dean, Wendy, Nichols, Jennifer, Marioni, John C., Reik, Wolf

“… The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast …”
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Global Reorganization of the Nuclear Landscape in Senescent Cells von Chandra, Tamir, Ewels, Philip Andrew, Schoenfelder, Stefan, Furlan-Magaril, Mayra, Wingett, Steven William, Kirschner, Kristina, Thuret, Jean-Yves, Andrews, Simon, Fraser, Peter, Reik, Wolf

“… Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming …”
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Polymer Modeling Predicts Chromosome Reorganization in Senescence von Chiang, Michael, Michieletto, Davide, Brackley, Chris A., Rattanavirotkul, Nattaphong, Mohammed, Hisham, Marenduzzo, Davide, Chandra, Tamir

“… Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape …”
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Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development von Crosse, Edie I, Gordon-Keylock, Sabrina, Rybtsov, Stanislav, Binagui-Casas, Anahi, Felchle, Hannah, Nnadi, Nneka C, Kirschner, Kristina, Chandra, Tamir, Tamagno, Sara, Webb, David J, Rossi, Fiona, Anderson, Richard A, Medvinsky, Alexander

“… Hematopoietic stem cells (HSCs) first emerge in the embryonic aorta-gonad-mesonephros (AGM) region. Studies of model organisms defined intersecting signaling …”
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Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells von Collinson, Adam, Collier, Amanda J., Morgan, Natasha P., Sienerth, Arnold R., Chandra, Tamir, Andrews, Simon, Rugg-Gunn, Peter J.

“… Through the histone methyltransferase EZH2, the Polycomb complex PRC2 mediates H3K27me3 and is associated with transcriptional repression. PRC2 regulates …”
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Notch Signaling Mediates Secondary Senescence von Teo, Yee Voan, Rattanavirotkul, Nattaphong, Olova, Nelly, Salzano, Angela, Quintanilla, Andrea, Tarrats, Nuria, Kiourtis, Christos, Müller, Miryam, Green, Anthony R., Adams, Peter D., Acosta, Juan-Carlos, Bird, Thomas G., Kirschner, Kristina, Neretti, Nicola, Chandra, Tamir

“… Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors …”
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Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence von Sadaie, Mahito, Salama, Rafik, Carroll, Thomas, Tomimatsu, Kosuke, Chandra, Tamir, Young, Andrew R J, Narita, Masako, Pérez-Mancera, Pedro A, Bennett, Dorothy C, Chong, Heung, Kimura, Hiroshi, Narita, Masashi

“… Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the …”
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An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells von Berrens, Rebecca V, Andrews, Simon, Spensberger, Dominik, Santos, Fátima, Dean, Wendy, Gould, Poppy, Sharif, Jafar, Olova, Nelly, Chandra, Tamir, Koseki, Haruhiko, von Meyenn, Ferdinand, Reik, Wolf

“… Erasure of DNA methylation and repressive chromatin marks in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs) …”
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Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis von O'Sullivan, Eoin D, Mylonas, Katie J, Xin, Cuiyan, Baird, David P, Carvalho, Cyril, Docherty, Marie-Helena, Campbell, Ross, Matchett, Kylie P, Waddell, Scott H, Walker, Alexander D, Gallagher, Kevin M, Jia, Siyang, Leung, Steve, Laird, Alexander, Wilflingseder, Julia, Willi, Michaela, Reck, Maximilian, Finnie, Sarah, Pisco, Angela, Gordon-Keylock, Sabrina, Medvinsky, Alexander, Boulter, Luke, Henderson, Neil C, Kirschner, Kristina, Chandra, Tamir, Conway, Bryan R, Hughes, Jeremy, Denby, Laura, Bonventre, Joseph V, Ferenbach, David A

“… Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 …”
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Purifying stem cell‐derived red blood cells: a high‐throughput label‐free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration von Guzniczak, Ewa, Otto, Oliver, Whyte, Graeme, Chandra, Tamir, Robertson, Neil A., Willoughby, Nik, Jimenez, Melanie, Bridle, Helen

“… Cell‐based therapeutics, such as in vitro manufactured red blood cells (mRBCs), are different to traditional biopharmaceutical products (the final product …”
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Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype von Reck, Maximilian, Baird, David P., Veizades, Stefan, Sutherland, Callum, Bell, Rachel M. B., Hur, Heeyoun, Cairns, Carolynn, Janas, Piotr P., Campbell, Ross, Nam, Andy, Yang, Wei, Schurman, Nathan, Williams, Claire, O’Sullivan, Eoin, Beniazza, Meryam, Corsinotti, Andrea, Bellamy, Christopher, Hughes, Jeremy, Laird, Alexander, Denby, Laura, Chandra, Tamir, Ferenbach, David A., Conway, Bryan R.

“… Maladaptive proximal tubular (PT) epithelial cells have been implicated in progression of chronic kidney disease (CKD), however the complexity of epithelial …”
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An epigenome-wide association study of sex-specific chronological ageing von McCartney, Daniel L., Zhang, Futao, Hillary, Robert F., Zhang, Qian, Stevenson, Anna J., Walker, Rosie M., Bermingham, Mairead L., Boutin, Thibaud, Morris, Stewart W., Campbell, Archie, Murray, Alison D., Whalley, Heather C., Porteous, David J., Hayward, Caroline, Evans, Kathryn L., Chandra, Tamir, Deary, Ian J., McIntosh, Andrew M., Yang, Jian, Visscher, Peter M., McRae, Allan F., Marioni, Riccardo E.

“… Background Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life …”
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High-order chromatin structure and the epigenome in SAHFs von Chandra, Tamir, Narita, Masashi

“… It is almost ten years since senescence associated heterochromatic foci (SAHFs) were first described in human diploid fibroblasts (HDFs). Since then, a number …”
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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment von Kirschner, Kristina, Chandra, Tamir, Kiselev, Vladimir, Flores-Santa Cruz, David, Macaulay, Iain C., Park, Hyun Jun, Li, Juan, Kent, David G., Kumar, Rupa, Pask, Dean C., Hamilton, Tina L., Hemberg, Martin, Reik, Wolf, Green, Anthony R.

“… Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely …”
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Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation von Coupland, Paul, Chandra, Tamir, Quail, Mike, Reik, Wolf, Swerdlow, Harold

“… We have developed a sequencing method on the Pacific Biosciences RS sequencer (the PacBio) for small DNA molecules that avoids the need for a standard library …”
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