Výsledky vyhledávání - "Cellular Reprogramming Techniques/methods"

Generation of human oogonia from induced pluripotent stem cells in vitro Autor Yamashiro, Chika, Sasaki, Kotaro, Yabuta, Yukihiro, Kojima, Yoji, Nakamura, Tomonori, Okamoto, Ikuhiro, Yokobayashi, Shihori, Murase, Yusuke, Ishikura, Yukiko, Shirane, Kenjiro, Sasaki, Hiroyuki, Yamamoto, Takuya, Saitou, Mitinori

“…Human in vitro gametogenesis may transform reproductive medicine. Human pluripotent stem cells (hPSCs) have been induced into primordial germ cell-like cells…”
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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity Autor Funk, Christopher Ronald, Wang, Shuhua, Chen, Kevin Z, Waller, Alexandra, Sharma, Aditi, Edgar, Claudia L, Gupta, Vikas A, Chandrakasan, Shanmuganathan, Zoine, Jaquelyn T, Fedanov, Andrew, Raikar, Sunil S, Koff, Jean L, Flowers, Christopher R, Coma, Silvia, Pachter, Jonathan A, Ravindranathan, Sruthi, Spencer, H Trent, Shanmugam, Mala, Waller, Edmund K

“…Current limitations in using chimeric antigen receptor T(CART) cells to treat patients with hematological cancers include limited expansion and persistence…”
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A decade of transcription factor-mediated reprogramming to pluripotency Autor Takahashi, Kazutoshi, Yamanaka, Shinya

“…This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming…”
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Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success Autor Gascón, Sergio, Masserdotti, Giacomo, Russo, Gianluca Luigi, Götz, Magdalena

“…The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent…”
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Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures Autor Li, Ronghui, Zhong, Cuiqing, Yu, Yang, Liu, Haisong, Sakurai, Masahiro, Yu, Leqian, Min, Zheying, Shi, Lei, Wei, Yulei, Takahashi, Yuta, Liao, Hsin-Kai, Qiao, Jie, Deng, Hongkui, Nuñez-Delicado, Estrella, Rodriguez Esteban, Concepcion, Wu, Jun, Izpisua Belmonte, Juan Carlos

“…A single mouse blastomere from an embryo until the 8-cell stage can generate an entire blastocyst. Whether laboratory-cultured cells retain a similar…”
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A comprehensive library of human transcription factors for cell fate engineering Autor Ng, Alex H. M., Khoshakhlagh, Parastoo, Rojo Arias, Jesus Eduardo, Pasquini, Giovanni, Wang, Kai, Swiersy, Anka, Shipman, Seth L., Appleton, Evan, Kiaee, Kiavash, Kohman, Richie E., Vernet, Andyna, Dysart, Matthew, Leeper, Kathleen, Saylor, Wren, Huang, Jeremy Y., Graveline, Amanda, Taipale, Jussi, Hill, David E., Vidal, Marc, Melero-Martin, Juan M., Busskamp, Volker, Church, George M.

“…Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types and tissues. To enable systematic exploration of the…”
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Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models Autor Lee, C Y Daniel, Daggett, Anthony, Gu, Xiaofeng, Jiang, Lu-Lin, Langfelder, Peter, Li, Xiaoguang, Wang, Nan, Zhao, Yingjun, Park, Chang Sin, Cooper, Yonatan, Ferando, Isabella, Mody, Istvan, Coppola, Giovanni, Xu, Huaxi, Yang, X William

“…Variants of TREM2 are associated with Alzheimer's disease (AD). To study whether increasing TREM2 gene dosage could modify the disease pathogenesis, we…”
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Epigenetic control of CD8 + T cell differentiation Autor Henning, Amanda N, Roychoudhuri, Rahul, Restifo, Nicholas P

“…Upon stimulation, small numbers of naive CD8 T cells proliferate and differentiate into a variety of memory and effector cell types. CD8 T cells can persist…”
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Cardiac Tissues From Stem Cells: New Routes to Maturation and Cardiac Regeneration Autor Campostrini, Giulia, Windt, Laura M, van Meer, Berend J, Bellin, Milena, Mummery, Christine L

“…The ability of human pluripotent stem cells to form all cells of the body has provided many opportunities to study disease and produce cells that can be used…”
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Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex Autor Mattugini, Nicola, Bocchi, Riccardo, Scheuss, Volker, Russo, Gianluca Luigi, Torper, Olof, Lao, Chu Lan, Götz, Magdalena

“…Astrocytes are particularly promising candidates for reprogramming into neurons, as they maintain some of the original patterning information from their radial…”
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Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease Autor Wu, Zheng, Parry, Matthew, Hou, Xiao-Yi, Liu, Min-Hui, Wang, Hui, Cain, Rachel, Pei, Zi-Fei, Chen, Yu-Chen, Guo, Zi-Yuan, Abhijeet, Sambangi, Chen, Gong

“…Huntington’s disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss of striatal GABAergic neurons and motor functional deficits. We…”
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Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model Autor Rivetti di Val Cervo, Pia, Romanov, Roman A, Spigolon, Giada, Masini, Débora, Martín-Montañez, Elisa, Toledo, Enrique M, La Manno, Gioele, Feyder, Michael, Pifl, Christian, Ng, Yi-Han, Sánchez, Sara Padrell, Linnarsson, Sten, Wernig, Marius, Harkany, Tibor, Fisone, Gilberto, Arenas, Ernest

“…In vivo reprogramming of astrocytes to dopamine neurons improves motor behavior in a mouse model of Parkinson's disease. Cell replacement therapies for…”
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Strategies for Improving the Maturity of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Autor Tu, Chengyi, Chao, Benjamin S, Wu, Joseph C

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Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells Autor Weinberg, Benjamin H, Pham, N T Hang, Caraballo, Leidy D, Lozanoski, Thomas, Engel, Adrien, Bhatia, Swapnil, Wong, Wilson W

“…Genetic circuits that are reliable, robust, and scalable are built without the need for optimization using a recombinase-based system. Engineered genetic…”
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Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells: Methods, Applications, and Considerations Autor Shen, Mengcheng, Quertermous, Thomas, Fischbein, Michael P, Wu, Joseph C

“…The developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly recognized as a major determinant for regional susceptibility or…”
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Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors Autor Lalit, Pratik A, Salick, Max R, Nelson, Daryl O, Squirrell, Jayne M, Shafer, Christina M, Patel, Neel G, Saeed, Imaan, Schmuck, Eric G, Markandeya, Yogananda S, Wong, Rachel, Lea, Martin R, Eliceiri, Kevin W, Hacker, Timothy A, Crone, Wendy C, Kyba, Michael, Garry, Daniel J, Stewart, Ron, Thomson, James A, Downs, Karen M, Lyons, Gary E, Kamp, Timothy J

“…Several studies have reported reprogramming of fibroblasts into induced cardiomyocytes; however, reprogramming into proliferative induced cardiac progenitor…”
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Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue Autor Gallego-Perez, Daniel, Pal, Durba, Ghatak, Subhadip, Malkoc, Veysi, Higuita-Castro, Natalia, Gnyawali, Surya, Chang, Lingqian, Liao, Wei-Ching, Shi, Junfeng, Sinha, Mithun, Singh, Kanhaiya, Steen, Erin, Sunyecz, Alec, Stewart, Richard, Moore, Jordan, Ziebro, Thomas, Northcutt, Robert G., Homsy, Michael, Bertani, Paul, Lu, Wu, Roy, Sashwati, Khanna, Savita, Rink, Cameron, Sundaresan, Vishnu Baba, Otero, Jose J., Lee, L. James, Sen, Chandan K.

“…Arrayed nanochannels can be used to controllably transfect and reprogram tissues in vivo for applications in regenerative medicine and cell-based therapies…”
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Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2 Autor Lee, Sangho, Park, Changwon, Han, Ji Woong, Kim, Ju Young, Cho, Kyuwon, Kim, Eun Jae, Kim, Sangsung, Lee, Shin-Jeong, Oh, Se Yeong, Tanaka, Yoshiaki, Park, In-Hyun, An, Hyo Jae, Shin, Claire Min, Sharma, Shraya, Yoon, Young-Sup

“…Direct conversion or reprogramming of human postnatal cells into endothelial cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative…”
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High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling Autor Zhao, Yuanbiao, Londono, Pilar, Cao, Yingqiong, Sharpe, Emily J., Proenza, Catherine, O’Rourke, Rebecca, Jones, Kenneth L., Jeong, Mark Y., Walker, Lori A., Buttrick, Peter M., McKinsey, Timothy A., Song, Kunhua

“…Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C,…”
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The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation Autor Gross-Thebing, Theresa, Yigit, Sargon, Pfeiffer, Jana, Reichman-Fried, Michal, Bandemer, Jan, Ruckert, Christian, Rathmer, Christin, Goudarzi, Mehdi, Stehling, Martin, Tarbashevich, Katsiaryna, Seggewiss, Jochen, Raz, Erez

“…Maintaining cell fate relies on robust mechanisms that prevent the differentiation of specified cells into other cell types. This is especially critical during…”
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