Výsledky vyhledávání - "Cellular Reprogramming - genetics"

Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming Autor Chondronasiou, Dafni, Gill, Diljeet, Mosteiro, Lluc, Urdinguio, Rocio G., Berenguer‐Llergo, Antonio, Aguilera, Mònica, Durand, Sylvere, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Abad, Maria, Martin‐Herranz, Daniel E., Stephan‐Otto Attolini, Camille, Prats, Neus, Kroemer, Guido, Fraga, Mario F., Reik, Wolf, Serrano, Manuel

“… However, little is known about the mechanisms involved. Here, we have studied changes in the DNA methylome, transcriptome, and metabolome in naturally aged mice subject to a single period of transient OSKM expression…”
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Genomic imprinting in development, growth, behavior and stem cells Autor Plasschaert, Robert N, Bartolomei, Marisa S

“…Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele…”
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Age reprogramming: cell rejuvenation by partial reprogramming Autor Singh, Prim B, Zhakupova, Assem

“…'Age reprogramming' refers to the process by which the molecular and cellular pathways of a cell that are subject to age-related decline are rejuvenated without passage through an embryonic stage…”
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Reprogramming of murine and human somatic cells using a single polycistronic vector Autor Carey, Bryce W, Markoulaki, Styliani, Hanna, Jacob, Saha, Kris, Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf

“…Directed reprogramming of somatic cells by defined factors provides a novel method for the generation of patient-specific stem cells with the potential to…”
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Targeted removal of epigenetic barriers during transcriptional reprogramming Autor Baumann, Valentin, Wiesbeck, Maximilian, Breunig, Christopher T., Braun, Julia M., Köferle, Anna, Ninkovic, Jovica, Götz, Magdalena, Stricker, Stefan H.

“…Master transcription factors have the ability to direct and reverse cellular identities, and consequently their genes must be subject to particular transcriptional control…”
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Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition Autor Silva, Jose, Barrandon, Ornella, Nichols, Jennifer, Kawaguchi, Jitsutaro, Theunissen, Thorold W, Smith, Austin

“… Tissue stem cells may be subject to less-stringent epigenetic restrictions than other cells and might therefore be more amenable to deprogramming…”
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Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL -Deficient Kidney Tissue Autor Nguyen-Tran, Hieu-Huy, Nguyen, Thi-Ngoc, Chen, Chen-Yun, Hsu, Tien

“…Clear-cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma (RCC), and its progression has been linked to chronic…”
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The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells Autor Sharma, Amit, Diecke, Sebastian, Zhang, Wendy Y, Lan, Feng, He, Chunjiang, Mordwinkin, Nicholas M, Chua, Katrin F, Wu, Joseph C

“…) from older human subjects were more resistant to reprogramming by classic Yamanaka factors than those from younger human subjects, but the addition of SIRT6 during reprogramming improved…”
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Blockade of senescence‐associated microRNA‐195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells Autor Kondo, Hideyuki, Kim, Ha Won, Wang, Lei, Okada, Motoi, Paul, Christian, Millard, Ronald W., Wang, Yigang

“…Summary The low reprogramming efficiency in cells from elderly patients is a challenge that must be overcome. Recently, it has been reported that…”
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Eight-gene metabolic signature related with tumor-associated macrophages predicting overall survival for hepatocellular carcinoma Autor Huo, Junyu, Wu, Liqun, Zang, Yunjin, Dong, Hongjing, Liu, Xiaoqiang, He, Fu, Zhang, Xiao

“…) in the Cancer Genome Atlas (TCGA) as study subjects. Kaplan-Meier survival analysis assisted in determining the relationship between macrophage infiltration and overall survival (OS…”
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Telomere Dynamics in Human Cells Reprogrammed to Pluripotency Autor Suhr, Steven T., Chang, Eun Ah, Rodriguez, Ramon M., Wang, Kai, Ross, Pablo J., Beyhan, Zeki, Murthy, Shashanka, Cibelli, Jose B.

“… A question remains as to the biological age of IPSCs, in particular when isolated from older subjects…”
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A Link between Genetic Disorders and Cellular Impairment, Using Human Induced Pluripotent Stem Cells to Reveal the Functional Consequences of Copy Number Variations in the Central Nervous System—A Close Look at Chromosome 15 Autor Casamassa, Alessia, Ferrari, Daniela, Gelati, Maurizio, Carella, Massimo, Vescovi, Angelo Luigi, Rosati, Jessica

“…Recent cutting-edge human genetics technology has allowed us to identify copy number variations (CNVs) and has provided new insights for understanding…”
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Absence of an embryonic stem cell DNA methylation signature in human cancer Autor Zhang, Ze, Wiencke, John K., Koestler, Devin C., Salas, Lucas A., Christensen, Brock C., Kelsey, Karl T.

“…Background Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal…”
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Establishment of a human iPSC line (MUSIi007-A) from peripheral blood of normal individual using Sendai viral vectors Autor Potirat, Ponthip, Wattanapanitch, Methichit, Kheolamai, Pakpoom, Issaragrisil, Surapol

“…) isolated from a 26-year-old healthy subject to use as a control group for the iPSC line carrying compound heterozygote for mutation in KLF1 gene…”
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Epigenetic regulation of genetic integrity is reprogrammed during cloning Autor Murphey, Patricia, Yamazaki, Yukiko, McMahan, C Alex, Walter, Christi A, Yanagimachi, Ryuzo, McCarrey, John R

“…Cloning by somatic cell nuclear transfer (SCNT) circumvents processes that normally function during gametogenesis to prepare the gamete genomes to support…”
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