Výsledky vyhľadávania - "Cellular Reprogramming/genetics"

Nobel Prize in Physiology or Medicine 2012. The daring adventure of reprogramming cells Autor Etcheverry, Guillermo Jaim

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Lineage tracing: The gold standard to claim direct reprogramming in vivo Autor Svendsen, Clive N, Sofroniew, Michael V

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Induced Pluripotent Stem Cells Meet Genome Editing Autor Hockemeyer, Dirk, Jaenisch, Rudolf

“…It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how…”
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Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming Autor Schiebinger, Geoffrey, Shu, Jian, Tabaka, Marcin, Cleary, Brian, Subramanian, Vidya, Solomon, Aryeh, Gould, Joshua, Liu, Siyan, Lin, Stacie, Berube, Peter, Lee, Lia, Chen, Jenny, Brumbaugh, Justin, Rigollet, Philippe, Hochedlinger, Konrad, Jaenisch, Rudolf, Regev, Aviv, Lander, Eric S

“…Understanding the molecular programs that guide differentiation during development is a major challenge. Here, we introduce Waddington-OT, an approach for…”
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Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity Autor Skrypek, Nicolas, Goossens, Steven, De Smedt, Eva, Vandamme, Niels, Berx, Geert

“…Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their junctions and polarity to gain a motile mesenchymal phenotype. EMT…”
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Deterministic reprogramming of neutrophils within tumors Autor Ng, Melissa S F, Kwok, Immanuel, Tan, Leonard, Shi, Changming, Cerezo-Wallis, Daniela, Tan, Yingrou, Leong, Keith, Calvo, Gabriel F, Yang, Katharine, Zhang, Yuning, Jin, Jingsi, Liong, Ka Hang, Wu, Dandan, He, Rui, Liu, Dehua, Teh, Ye Chean, Bleriot, Camille, Caronni, Nicoletta, Liu, Zhaoyuan, Duan, Kaibo, Narang, Vipin, Ballesteros, Iván, Moalli, Federica, Li, Mengwei, Chen, Jinmiao, Liu, Yao, Liu, Lianxin, Qi, Jingjing, Liu, Yingbin, Jiang, Lingxi, Shen, Baiyong, Cheng, Hui, Cheng, Tao, Angeli, Veronique, Sharma, Ankur, Loh, Yuin-Han, Tey, Hong Liang, Chong, Shu Zhen, Iannacone, Matteo, Ostuni, Renato, Hidalgo, Andrés, Ginhoux, Florent, Ng, Lai Guan

“…Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances…”
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DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos Autor Messerschmidt, Daniel M, Knowles, Barbara B, Solter, Davor

“…Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic development, cells are directed toward their future lineages, and…”
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Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential Autor Ohnuki, Mari, Tanabe, Koji, Sutou, Kenta, Teramoto, Ito, Sawamura, Yuka, Narita, Megumi, Nakamura, Michiko, Tokunaga, Yumie, Nakamura, Masahiro, Watanabe, Akira, Yamanaka, Shinya, Takahashi, Kazutoshi

“…Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2…”
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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments Autor Angelin, Alessia, Gil-de-Gómez, Luis, Dahiya, Satinder, Jiao, Jing, Guo, Lili, Levine, Matthew H, Wang, Zhonglin, Quinn, 3rd, William J, Kopinski, Piotr K, Wang, Liqing, Akimova, Tatiana, Liu, Yujie, Bhatti, Tricia R, Han, Rongxiang, Laskin, Benjamin L, Baur, Joseph A, Blair, Ian A, Wallace, Douglas C, Hancock, Wayne W, Beier, Ulf H

“…Immune cells function in diverse metabolic environments. Tissues with low glucose and high lactate concentrations, such as the intestinal tract or ischemic…”
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Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment Autor Dey, Prasenjit, Li, Jun, Zhang, Jianhua, Chaurasiya, Surendra, Strom, Anders, Wang, Huamin, Liao, Wen-Ting, Cavallaro, Frederick, Denz, Parker, Bernard, Vincent, Yen, Er-Yen, Genovese, Giannicola, Gulhati, Pat, Liu, Jielin, Chakravarti, Deepavali, Deng, Pingna, Zhang, Tingxin, Carbone, Federica, Chang, Qing, Ying, Haoqiang, Shang, Xiaoying, Spring, Denise J, Ghosh, Bidyut, Putluri, Nagireddy, Maitra, Anirban, Wang, Y Alan, DePinho, Ronald A

“…A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised of diverse cell types that enable or suppress tumor progression. Here,…”
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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade Autor Pauken, Kristen E, Sammons, Morgan A, Odorizzi, Pamela M, Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M, Chen, Zeyu, Sen, Debattama R, Kurachi, Makoto, Barnitz, R Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C, Schenkel, Jason M, Vahedi, Golnaz, Haining, W Nicholas, Berger, Shelley L, Wherry, E John

“…Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 T cells (T ) and improve control of chronic infections and cancer. However, whether blocking…”
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Long noncoding RNAs in cell-fate programming and reprogramming Autor Flynn, Ryan A, Chang, Howard Y

“…In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of regulators of gene expression. lncRNAs exhibit several distinctive…”
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Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis Autor Xiong, Xuelian, Kuang, Henry, Ansari, Sahar, Liu, Tongyu, Gong, Jianke, Wang, Shuai, Zhao, Xu-Yun, Ji, Yewei, Li, Chuan, Guo, Liang, Zhou, Linkang, Chen, Zhimin, Leon-Mimila, Paola, Chung, Meng Ting, Kurabayashi, Katsuo, Opp, Judy, Campos-Pérez, Francisco, Villamil-Ramírez, Hugo, Canizales-Quinteros, Samuel, Lyons, Robert, Lumeng, Carey N, Zhou, Beiyan, Qi, Ling, Huertas-Vazquez, Adriana, Lusis, Aldons J, Xu, X Z Shawn, Li, Siming, Yu, Yonghao, Li, Jun Z, Lin, Jiandie D

“…Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex organs. Despite this, the global landscape of intercellular signaling…”
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Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment Autor Xu, Qianhua, Xie, Wei

“…Drastic epigenetic reprogramming takes place during preimplantation development, leading to the conversion of terminally differentiated gametes to a totipotent…”
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Direct cell reprogramming: approaches, mechanisms and progress Autor Wang, Haofei, Yang, Yuchen, Liu, Jiandong, Qian, Li

“…The reprogramming of somatic cells with defined factors, which converts cells from one lineage into cells of another, has greatly reshaped our traditional…”
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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis Autor Seidman, Jason S, Troutman, Ty D, Sakai, Mashito, Gola, Anita, Spann, Nathanael J, Bennett, Hunter, Bruni, Cassi M, Ouyang, Zhengyu, Li, Rick Z, Sun, Xiaoli, Vu, BaoChau T, Pasillas, Martina P, Ego, Kaori M, Gosselin, David, Link, Verena M, Chong, Ling-Wa, Evans, Ronald M, Thompson, Bonne M, McDonald, Jeffrey G, Hosseini, Mojgan, Witztum, Joseph L, Germain, Ronald N, Glass, Christopher K

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
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Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma Autor Kim, Nayoung, Kim, Hong Kwan, Lee, Kyungjong, Hong, Yourae, Cho, Jong Ho, Choi, Jung Won, Lee, Jung-Il, Suh, Yeon-Lim, Ku, Bo Mi, Eum, Hye Hyeon, Choi, Soyean, Choi, Yoon-La, Joung, Je-Gun, Park, Woong-Yang, Jung, Hyun Ae, Sun, Jong-Mu, Lee, Se-Hoon, Ahn, Jin Seok, Park, Keunchil, Ahn, Myung-Ju, Lee, Hae-Ock

“…Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we…”
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Gene regulatory networks controlling vertebrate retinal regeneration Autor Hoang, Thanh, Wang, Jie, Boyd, Patrick, Wang, Fang, Santiago, Clayton, Jiang, Lizhi, Yoo, Sooyeon, Lahne, Manuela, Todd, Levi J, Jia, Meng, Saez, Cristian, Keuthan, Casey, Palazzo, Isabella, Squires, Natalie, Campbell, Warren A, Rajaii, Fatemeh, Parayil, Trisha, Trinh, Vickie, Kim, Dong Won, Wang, Guohua, Campbell, Leah J, Ash, John, Fischer, Andy J, Hyde, David R, Qian, Jiang, Blackshaw, Seth

“…Injury induces retinal Müller glia of certain cold-blooded vertebrates, but not those of mammals, to regenerate neurons. To identify gene regulatory networks…”
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Reprogramming the genetic code Autor de la Torre, Daniel, Chin, Jason W.

“…The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity synthesis of long polymers of defined sequence and composition, but it is…”
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Overcoming muscle stem cell aging Autor Memczak, Sebastian, Belmonte, Juan CI

“…Reduced muscle strength and mass is one of the hallmarks of physiological aging in humans and can result in severe impairment of the quality of life. In part…”
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