Search Results - "Cellular Reprogramming"

A decade of transcription factor-mediated reprogramming to pluripotency by Takahashi, Kazutoshi, Yamanaka, Shinya

“…This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming…”
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TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming by Tang, Yawen, Aryal, Sajesan, Geng, Xiaoxiao, Zhou, Xinyue, Fast, Vladimir G, Zhang, Jianyi, Lu, Rui, Zhou, Yang

“…Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged as a promising strategy to remuscularize injured myocardium. However, it is…”
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Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential by Ohnuki, Mari, Tanabe, Koji, Sutou, Kenta, Teramoto, Ito, Sawamura, Yuka, Narita, Megumi, Nakamura, Michiko, Tokunaga, Yumie, Nakamura, Masahiro, Watanabe, Akira, Yamanaka, Shinya, Takahashi, Kazutoshi

“…Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2…”
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Glycosphingolipid metabolic reprogramming drives neural differentiation by Russo, Domenico, Della Ragione, Floriana, Rizzo, Riccardo, Sugiyama, Eiji, Scalabrì, Francesco, Hori, Kei, Capasso, Serena, Sticco, Lucia, Fioriniello, Salvatore, De Gregorio, Roberto, Granata, Ilaria, Guarracino, Mario R, Maglione, Vittorio, Johannes, Ludger, Bellenchi, Gian Carlo, Hoshino, Mikio, Setou, Mitsutoshi, D'Esposito, Maurizio, Luini, Alberto, D'Angelo, Giovanni

“…Neural development is accomplished by differentiation events leading to metabolic reprogramming. Glycosphingolipid metabolism is reprogrammed during neural…”
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Deterministic reprogramming of neutrophils within tumors by Ng, Melissa S F, Kwok, Immanuel, Tan, Leonard, Shi, Changming, Cerezo-Wallis, Daniela, Tan, Yingrou, Leong, Keith, Calvo, Gabriel F, Yang, Katharine, Zhang, Yuning, Jin, Jingsi, Liong, Ka Hang, Wu, Dandan, He, Rui, Liu, Dehua, Teh, Ye Chean, Bleriot, Camille, Caronni, Nicoletta, Liu, Zhaoyuan, Duan, Kaibo, Narang, Vipin, Ballesteros, Iván, Moalli, Federica, Li, Mengwei, Chen, Jinmiao, Liu, Yao, Liu, Lianxin, Qi, Jingjing, Liu, Yingbin, Jiang, Lingxi, Shen, Baiyong, Cheng, Hui, Cheng, Tao, Angeli, Veronique, Sharma, Ankur, Loh, Yuin-Han, Tey, Hong Liang, Chong, Shu Zhen, Iannacone, Matteo, Ostuni, Renato, Hidalgo, Andrés, Ginhoux, Florent, Ng, Lai Guan

“…Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances…”
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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments by Angelin, Alessia, Gil-de-Gómez, Luis, Dahiya, Satinder, Jiao, Jing, Guo, Lili, Levine, Matthew H, Wang, Zhonglin, Quinn, 3rd, William J, Kopinski, Piotr K, Wang, Liqing, Akimova, Tatiana, Liu, Yujie, Bhatti, Tricia R, Han, Rongxiang, Laskin, Benjamin L, Baur, Joseph A, Blair, Ian A, Wallace, Douglas C, Hancock, Wayne W, Beier, Ulf H

“…Immune cells function in diverse metabolic environments. Tissues with low glucose and high lactate concentrations, such as the intestinal tract or ischemic…”
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Cell Fate Reprogramming in the Era of Cancer Immunotherapy by Zimmermannova, Olga, Caiado, Inês, Ferreira, Alexandra G., Pereira, Carlos-Filipe

“…Advances in understanding how cancer cells interact with the immune system allowed the development of immunotherapeutic strategies, harnessing patients’ immune…”
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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade by Pauken, Kristen E, Sammons, Morgan A, Odorizzi, Pamela M, Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M, Chen, Zeyu, Sen, Debattama R, Kurachi, Makoto, Barnitz, R Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C, Schenkel, Jason M, Vahedi, Golnaz, Haining, W Nicholas, Berger, Shelley L, Wherry, E John

“…Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 T cells (T ) and improve control of chronic infections and cancer. However, whether blocking…”
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Direct cell reprogramming: approaches, mechanisms and progress by Wang, Haofei, Yang, Yuchen, Liu, Jiandong, Qian, Li

“…The reprogramming of somatic cells with defined factors, which converts cells from one lineage into cells of another, has greatly reshaped our traditional…”
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Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation by Gehrmann, Ulf, Burbage, Marianne, Zueva, Elina, Goudot, Christel, Esnault, Cyril, Ye, Mengliang, Carpier, Jean-Marie, Burgdorf, Nina, Hoyler, Thomas, Suarez, Guadalupe, Joannas, Leonel, Heurtebise-Chrétien, Sandrine, Durand, Sylvère, Panes, Rébecca, Bellemare-Pelletier, Angélique, Sáez, Pablo J, Aprahamian, Fanny, Lefevre, Deborah, Adoue, Veronique, Zine El Aabidine, Amal, Muhammad Ahmad, Maqbool, Hivroz, Claire, Joffre, Olivier, Cammas, Florence, Kroemer, Guido, Gagnon, Etienne, Andrau, Jean-Christophe, Amigorena, Sebastian

“…Naive CD4 T lymphocytes differentiate into different effector types, including helper and regulatory cells (Th and Treg, respectively). Heritable gene…”
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Cell competition during reprogramming gives rise to dominant clones by Shakiba, Nika, Fahmy, Ahmed, Jayakumaran, Gowtham, McGibbon, Sophie, David, Laurent, Trcka, Daniel, Elbaz, Judith, Puri, Mira C, Nagy, Andras, van der Kooy, Derek, Goyal, Sidhartha, Wrana, Jeffrey L, Zandstra, Peter W

“…The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have…”
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ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression by Zhou, Huanyu, Morales, Maria Gabriela, Hashimoto, Hisayuki, Dickson, Matthew E, Song, Kunhua, Ye, Wenduo, Kim, Min S, Niederstrasser, Hanspeter, Wang, Zhaoning, Chen, Beibei, Posner, Bruce A, Bassel-Duby, Rhonda, Olson, Eric N

“…Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the…”
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Plant regeneration: cellular origins and molecular mechanisms by Ikeuchi, Momoko, Ogawa, Yoichi, Iwase, Akira, Sugimoto, Keiko

“…Compared with animals, plants generally possess a high degree of developmental plasticity and display various types of tissue or organ regeneration. This…”
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Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas by Inoue, Kimiko, Ogonuki, Narumi, Kamimura, Satoshi, Inoue, Hiroki, Matoba, Shogo, Hirose, Michiko, Honda, Arata, Miura, Kento, Hada, Masashi, Hasegawa, Ayumi, Watanabe, Naomi, Dodo, Yukiko, Mochida, Keiji, Ogura, Atsuo

“…Somatic cell nuclear transfer (SCNT) in mammals is an inefficient process that is frequently associated with abnormal phenotypes, especially in placentas…”
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A Gene Regulatory Network for Cellular Reprogramming in Plant Regeneration by Ikeuchi, Momoko, Shibata, Michitaro, Rymen, Bart, Iwase, Akira, B�gman, Anne-Maarit, Watt, Lewis, Coleman, Duncan, Favero, David S, Takahashi, Tatsuya, Ahnert, Sebastian E, Brady, Siobhan M, Sugimoto, Keiko

“…Abstract Wounding triggers organ regeneration in many plant species, and application of plant hormones, such as auxin and cytokinin, enhances their…”
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Nuclear reprogramming to a pluripotent state by three approaches by Yamanaka, Shinya, Blau, Helen M.

“…The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be…”
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The ERK and JNK pathways in the regulation of metabolic reprogramming by Papa, Salvatore, Choy, Pui Man, Bubici, Concetta

“…Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of…”
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Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming by Gascón, Sergio, Murenu, Elisa, Masserdotti, Giacomo, Ortega, Felipe, Russo, Gianluca L, Petrik, David, Deshpande, Aditi, Heinrich, Christophe, Karow, Marisa, Robertson, Stephen P, Schroeder, Timm, Beckers, Johannes, Irmler, Martin, Berndt, Carsten, Angeli, José P Friedmann, Conrad, Marcus, Berninger, Benedikt, Götz, Magdalena

“…Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a…”
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Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons by Li, Xiang, Zuo, Xiaohan, Jing, Junzhan, Ma, Yantao, Wang, Jiaming, Liu, Defang, Zhu, Jialiang, Du, Xiaomin, Xiong, Liang, Du, Yuanyuan, Xu, Jun, Xiao, Xiong, Wang, Jinlin, Chai, Zhen, Zhao, Yang, Deng, Hongkui

“…Recently, direct reprogramming between divergent lineages has been achieved by the introduction of regulatory transcription factors. This approach may provide…”
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Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success by Gascón, Sergio, Masserdotti, Giacomo, Russo, Gianluca Luigi, Götz, Magdalena

“…The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent…”
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