Suchergebnisse - "Cellular Reprogramming"

Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming von Chen, Chien-Tsun, Hsu, Shu-Han, Wei, Yau-Huei

“… The self-renewal ability and pluripotent differentiation potential of stem cells hold great promise for regenerative medicine. Many studies focus on the …”
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Tumor necrosis factor promotes doublecortin-like kinase 1 expression and cellular reprogramming in intestinal epithelial cells leading to neoplastic transformation von Huang, Lin, Li, Tianqi, Huang, Xu, Chen, Xiaoxi, Ju, Yuanyuan, Xu, Lili, Ma, Chunhua, Tao, Yumei, Yang, Yonghong, Bian, Xiaoyun, Huycke, Mark M., Wang, Xingmin

“… Notably, DCLK1 expression correlated positively with inflammation, TNF levels, and TNFRSF1a in human subjects …”
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Deciphering two decades of cellular reprogramming in cancer: A bibliometric analysis of evolving trends and research frontiers von Liang, Jinghao, Lin, Yijian, Liu, Yuanqing, Lin, Hongmiao, Xie, Zixian, Wu, Tongtong, Zhang, Xinrong, Zhou, Xinyi, Tan, Zhaofeng, Yin, Weiqiang, Guo, Zhihua

“… Recent research has reevaluated the traditional view of cancer's linear progression and recurrence by introducing cellular reprogramming a process in which cancer cells can their state under certain conditions …”
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Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes von Rocchetti, Marcella, Sala, Luca, Dreizehnter, Lisa, Crotti, Lia, Sinnecker, Daniel, Mura, Manuela, Pane, Luna Simona, Altomare, Claudia, Torre, Eleonora, Mostacciuolo, Gaspare, Severi, Stefano, Porta, Alberto, De Ferrari, Gaetano M, George, Jr, Alfred L, Schwartz, Peter J, Gnecchi, Massimiliano, Moretti, Alessandra, Zaza, Antonio

“… Skin fibroblasts of the mutation carrier and two unrelated healthy subjects (controls) were reprogrammed to hiPSC and differentiated into hiPSC-CMs …”
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Macrophage Immunometabolism: Where Are We (Going)? von Van den Bossche, Jan, O’Neill, Luke A., Menon, Deepthi

“… A growing number of findings highlight the crucial role of metabolic reprogramming in macrophage activation. Metabolic pathways are closely interconnected and …”
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Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition von Silva, Jose, Barrandon, Ornella, Nichols, Jennifer, Kawaguchi, Jitsutaro, Theunissen, Thorold W, Smith, Austin

“… Tissue stem cells may be subject to less-stringent epigenetic restrictions than other cells and might therefore be more amenable to deprogramming …”
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The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells von Sharma, Amit, Diecke, Sebastian, Zhang, Wendy Y, Lan, Feng, He, Chunjiang, Mordwinkin, Nicholas M, Chua, Katrin F, Wu, Joseph C

“… ) from older human subjects were more resistant to reprogramming by classic Yamanaka factors than those from younger human subjects, but the addition of SIRT6 during reprogramming improved …”
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Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming von Chondronasiou, Dafni, Gill, Diljeet, Mosteiro, Lluc, Urdinguio, Rocio G., Berenguer‐Llergo, Antonio, Aguilera, Mònica, Durand, Sylvere, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Abad, Maria, Martin‐Herranz, Daniel E., Stephan‐Otto Attolini, Camille, Prats, Neus, Kroemer, Guido, Fraga, Mario F., Reik, Wolf, Serrano, Manuel

“… However, little is known about the mechanisms involved. Here, we have studied changes in the DNA methylome, transcriptome, and metabolome in naturally aged mice subject to a single period of transient OSKM expression …”
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Safety Profile of Good Manufacturing Practice Manufactured Interferon γ‐Primed Mesenchymal Stem/Stromal Cells for Clinical Trials von Guess, Adam J., Daneault, Beth, Wang, Rongzhang, Bradbury, Hillary, La Perle, Krista M. D., Fitch, James, Hedrick, Sheri L., Hamelberg, Elizabeth, Astbury, Caroline, White, Peter, Overolt, Kathleen, Rangarajan, Hemalatha, Abu‐Arja, Rolla, Devine, Steven M., Otsuru, Satoru, Dominici, Massimo, O'Donnell, Lynn, Horwitz, Edwin M.

“… Mesenchymal stem/stromal cells (MSCs) are widely studied by both academia and industry for a broad array of clinical indications. The collective body of data …”
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Genomic imprinting in development, growth, behavior and stem cells von Plasschaert, Robert N, Bartolomei, Marisa S

“… Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele …”
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Age reprogramming: cell rejuvenation by partial reprogramming von Singh, Prim B, Zhakupova, Assem

“… 'Age reprogramming' refers to the process by which the molecular and cellular pathways of a cell that are subject to age-related decline are rejuvenated without passage through an embryonic stage …”
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Derivation of two induced pluripotent stem cell lines from a healthy control subject von Zhang, Dan, Huang, Di, Larcher, Leon M., Zaw, Khine, Chen, Shang-Chih, Jennings, Luke, Lamey, Tina M., Thompson, Jennifer A., McLaren, Terri L., Chen, Fred K., McLenachan, Samuel

“… Two human induced pluripotent stem cell lines, LEIi021-A and LEIi021-B, were derived from dermal fibroblasts from a healthy control subject from an Australian Aboriginal family with retinitis pigmentosa-11 …”
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Reprogramming of murine and human somatic cells using a single polycistronic vector von Carey, Bryce W, Markoulaki, Styliani, Hanna, Jacob, Saha, Kris, Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf

“… Directed reprogramming of somatic cells by defined factors provides a novel method for the generation of patient-specific stem cells with the potential to …”
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The promise of induced pluripotent stem cells in research and therapy von Robinton, Daisy A., Daley, George Q.

“… The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to …”
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Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts von Vosough, Massoud, Ravaioli, Francesco, Zabulica, Mihaela, Capri, Miriam, Garagnani, Paolo, Franceschi, Claudio, Piccand, Julie, Kraus, Marine R.-C., Kannisto, Kristina, Gramignoli, Roberto, Strom, Stephen C.

“… Induced pluripotent stem cell (iPSC)-technology is an important platform in medicine and disease modeling. Physiological degeneration and disease onset are …”
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Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis von Chanda, Diptiman, Kurundkar, Ashish, Rangarajan, Sunad, Locy, Morgan, Bernard, Karen, Sharma, Nirmal S., Logsdon, Naomi J., Liu, Hui, Crossman, David K., Horowitz, Jeffrey C., De Langhe, Stijn, Thannickal, Victor J.

“… % decline, respectively, in forced vital capacity over the preceding 6-month period. Gene expression profiles of MSCs from IPF subjects with progressive …”
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Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM) von Bruntz, Ronald C, Lane, Andrew N, Higashi, Richard M, Fan, Teresa W-M

“… from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects …”
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Imaging of Induced Pluripotent Stem Cells: From Cellular Reprogramming to Transplantation von Cai, Weibo, Zhang, Yin, Kamp, Timothy J

“… of cellular reprogramming, to in vivo imaging of the survival of transplanted cells. To date, most imaging …”
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Targeted removal of epigenetic barriers during transcriptional reprogramming von Baumann, Valentin, Wiesbeck, Maximilian, Breunig, Christopher T., Braun, Julia M., Köferle, Anna, Ninkovic, Jovica, Götz, Magdalena, Stricker, Stefan H.

“… Master transcription factors have the ability to direct and reverse cellular identities, and consequently their genes must be subject to particular transcriptional control …”
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Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis von Yoder, Mervin C, Sen, Chandan K

“… There is an ongoing need for innovative cell and regenerative medicine therapies to promote vascular repair and regeneration to meet the growing global health …”
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