Výsledky vyhľadávania - "Cell structures and functions"

15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders Autor Hogart, Amber, Nagarajan, Raman P, Patzel, Katherine A, Yasui, Dag H, Lasalle, Janine M

“…Human chromosome 15q11-13 is a complex locus containing imprinted genes as well as a cluster of three GABA(A) receptor subunit (GABR) genes-GABRB3, GABRA5 and…”
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Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica Autor Hinson, S R, Pittock, S J, Lucchinetti, C F, Roemer, S F, Fryer, J P, Kryzer, T J, Lennon, V A

“…Autoantibody specific for the aquaporin-4 astrocytic water channel is restricted to serum and CSF of patients with neuromyelitis optica (NMO) and related CNS…”
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Molecular mechanisms of memory reconsolidation Autor Tronson, Natalie C., Taylor, Jane R.

“…Key Points Reconsolidation has been conceptualized as a post-retrieval process that stabilizes memory made labile by retrieval. This theory remains…”
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Routes, destinations and delays: recent advances in AMPA receptor trafficking Autor Henley, Jeremy M., Barker, Ellen A., Glebov, Oleg O.

“… that control their synaptic delivery, retention and removal are the subject of extensive research…”
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Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis Autor Templeman, Lucy A, Reynolds, Gavin P, Arranz, Belen, San, Luis

“… Two recent studies in the same cohort of Chinese Han subjects have shown that polymorphisms of the promoter regions of both the serotonin 5-hydroxytryptamine 2C (5-HT2C…”
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Nedd4‐mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking Autor Lin, Amy, Hou, Qingming, Jarzylo, Larissa, Amato, Steve, Gilbert, James, Shang, Fu, Man, Heng‐Ye

“… trafficking and stability are still not fully understood. Here, we report that mammalian AMPARs are subject to ubiquitination in neurons and in transfected heterologous cells…”
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Biopolymer organization upon confinement Autor Marenduzzo, D, Micheletti, C, Orlandini, E

“…Biopolymers in vivo are typically subject to spatial restraints, either as a result of molecular crowding in the cellular medium or of direct spatial confinement…”
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Endothelial cell culture model for replication of physiological profiles of pressure, flow, stretch, and shear stress in vitro Autor Estrada, Rosendo, Giridharan, Guruprasad A, Nguyen, Mai-Dung, Roussel, Thomas J, Shakeri, Mostafa, Parichehreh, Vahidreza, Prabhu, Sumanth D, Sethu, Palaniappan

“… Cells within this system were cultured on a stretchable, thin (∼500 μm) planar membrane within a rectangular flow channel and subject to constant fluid flow…”
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Plasma serotonin levels and the platelet serotonin transporter Autor Brenner, B, Harney, J.T, Ahmed, B.A, Jeffus, B.C, Unal, R, Mehta, J.L, Kilic, F

“…: (i) in subjects with chronic hypertension or normotension; (ii) on platelets isolated from normotensive subjects and pretreated with 5HT at various concentrations…”
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Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease Autor Brand, Oliver J, Barrett, Jeffrey C, Simmonds, Matthew J, Newby, Paul R, McCabe, Christopher J, Bruce, Christopher K, Kysela, Boris, Carr-Smith, Jackie D, Brix, Thomas, Hunt, Penny J, Wiersinga, Wilmar M, Hegedüs, Laszlo, Connell, John, Wass, John A H, Franklyn, Jayne A, Weetman, Anthony P, Heward, Joanne M, Gough, Stephen C L

“… In the current study, we investigated a combined panel of 98 SNPs, including 70 tag SNPs, across an extended 800 kb region of the TSHR to refine association in a cohort of 768 GD subjects and 768 matched controls…”
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Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations Autor Benzinou, Michael, Chèvre, Jean-Claude, Ward, Kirsten J, Lecoeur, Cécile, Dina, Christian, Lobbens, Stephane, Durand, Emmanuelle, Delplanque, Jérome, Horber, Fritz F, Heude, Barbara, Balkau, Beverley, Borch-Johnsen, Knut, Jørgensen, Torben, Hansen, Torben, Pedersen, Oluf, Meyre, David, Froguel, Philippe

“…The therapeutic effects of cannabinoid receptor blockade on obesity-associated phenotypes underline the importance of the endocannabinoid pathway on the energy…”
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The expression of GLP‐1 receptor mRNA and protein allows the effect of GLP‐1 on glucose metabolism in the human hypothalamus and brainstem Autor Alvarez, Elvira, Martínez, M. Dolores, Roncero, Isabel, Chowen, Julie A., García‐Cuartero, Beatriz, Gispert, Juan D., Sanz, Carmen, Vázquez, Patricia, Maldonado, Antonio, De Cáceres, Javier, Desco, Manuel, Pozo, Miguel Angel, Blázquez, Enrique

“…In the present work, several experimental approaches were used to determine the presence of the glucagon‐like peptide‐1 receptor (GLP‐1R) and the biological…”
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Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer Autor Posson, David J., Ge, Pinghua, Miller, Christopher, Bezanilla, Francisco, Selvin, Paul R.

“… Understanding the physical movements of this voltage sensor is of fundamental importance and is the subject of controversy…”
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A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels Autor van Rossum, Elisabeth F.C., Koper, Jan W., Huizenga, Nannette A.T.M., Uitterlinden, André G., Janssen, Joop A.M.J.L., Brinkmann, Albert O., Grobbee, Diederick E., de Jong, Frank H., van Duyn, Cornelia M., Pols, Huibert A.P., Lamberts, Steven W.J.

“…A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol…”
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Emerging roles for neogenin and its ligands in CNS development Autor De Vries, Melissa, Cooper, Helen M

“…It is now well established that the netrin guidance cues and their receptors comprise a major molecular guidance system driving axon pathfinding during nervous…”
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Binding characteristics and sensitivity to endogenous dopamine of [11C]‐(+)‐PHNO, a new agonist radiotracer for imaging the high‐affinity state of D2 receptors in vivo using positron emission tomography Autor Ginovart, Nathalie, Galineau, Laurent, Willeit, Matthaeus, Mizrahi, Romina, Bloomfield, Peter M., Seeman, Philip, Houle, Sylvain, Kapur, Shitij, Wilson, Alan A.

“…‐subject comparisons showed that [11C]‐(+)‐PHNO BP in striatum was almost 2.5‐fold higher than that measured with [11C]‐(–)‐NPA ([11C]‐(–)‐N‐propyl‐norapomorphine…”
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Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites Autor Mürdter, Thomas E, Kerb, Reinhold, Turpeinen, Miia, Schroth, Werner, Ganchev, Boian, Böhmer, Gabriele M, Igel, Svitlana, Schaeffeler, Elke, Zanger, Ulrich, Brauch, Hiltrud, Schwab, Matthias

“…Clomiphene citrate is the most used drug for the treatment of female infertility, a common condition in western societies and developing countries. Despite…”
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Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers Autor Jönsson, E G, Nöthen, M M, Grünhage, F, Farde, L, Nakashima, Y, Propping, P, Sedvall, G C

“…The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects…”
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Not so strange bedfellows: G-protein-coupled receptors and Src family kinases Autor Luttrell, Deirdre K, Luttrell, Louis M

“… As such, their role in cellular growth control and malignant transformation has been the subject of intensive investigation…”
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The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers Autor Oertel, Bruno G, Schmidt, Ronald, Schneider, Andreas, Geisslinger, Gerd, Lötsch, Jörn

“…To investigate whether OPRM1 118A>G polymorphism affects analgesic and respiratory depressive effects of alfentanil and assess its role for the therapeutic…”
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