Výsledky vyhledávání - "Cell death and differentiation"

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis Autor Yang, Kun, Fan, Min, Wang, Xiaohui, Xu, Jingjing, Wang, Yana, Tu, Fei, Gill, P Spencer, Ha, Tuanzhu, Liu, Li, Williams, David L, Li, Chuanfu

“…High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear…”
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COVID-19 vaccines: where we stand and challenges ahead Autor Forni, Guido, Mantovani, Alberto

“…In the eleven months elapsed since the identification of the SARS-CoV-2 virus and its genome, an exceptional effort by the scientific community has led to the…”
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Cellular degradation systems in ferroptosis Autor Chen, Xin, Yu, Chunhua, Kang, Rui, Kroemer, Guido, Tang, Daolin

“…In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged units by the ubiquitin-proteasome system (UPS) and autophagy. Thus,…”
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Apoptotic cell death in disease-Current understanding of the NCCD 2023 Autor Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J M, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D'Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, Kanneganti, Thirumala-Devi

“…Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally…”
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 Autor Galluzzi, Lorenzo, Vitale, Ilio, Abrams, John M., Agostinis, Patrizia, Amelio, Ivano, Andrews, David W., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bertrand, Mathieu J. M., Blagosklonny, Mikhail V., Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Carmona-Gutierrez, Didac, Chan, Francis K.-M., Cheng, Emily H., Ciechanover, Aaron, Conrad, Marcus, Cubillos-Ruiz, Juan R., De Laurenzi, Vincenzo, De Maria, Ruggero, Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J., Garrido, Carmen, Gavathiotis, Evripidis, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Gross, Atan, Hardwick, J. Marie, Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Knight, Richard A., Levine, Beth, Linkermann, Andreas, Lipton, Stuart A., López-Otín, Carlos, Lowe, Scott W., Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Medema, Jan Paul, Meier, Pascal, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Nagata, Shigekazu, Nuñez, Gabriel, Oren, Moshe, Pasparakis, Manolis, Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro, Pinton, Paolo, Rehm, Markus, Ryan, Kevin M., Shao, Feng, Shi, Yufang, Silke, John, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas, Szabadkai, Gyorgy, Tang, Daolin, Tsujimoto, Yoshihide, Turk, Boris, Vandenabeele, Peter, Vander Heiden, Matthew G., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido

“…Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from…”
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Mitochondria and cell death-associated inflammation Autor Vringer, Esmee, Tait, Stephen W G

“…Mitochondria have recently emerged as key drivers of inflammation associated with cell death. Many of the pro-inflammatory pathways activated during cell death…”
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Specific expression and functions of circular RNAs Autor Misir, Sema, Wu, Nan, Yang, Burton B

“…In recent years, circular RNAs (circRNAs), a new class of RNA molecules characterized by their covalently closed circular structure, have become a new research…”
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Pyroptosis versus necroptosis: similarities, differences, and crosstalk Autor Frank, Daniel, Vince, James E

“…Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against…”
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Organelle-specific regulation of ferroptosis Autor Chen, Xin, Kang, Rui, Kroemer, Guido, Tang, Daolin

“…Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is involved in the development of multiple pathological conditions,…”
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Autophagy-dependent cell death Autor Denton, Donna, Kumar, Sharad

“…Autophagy-dependent cell death can be defined as cell demise that has a strict requirement of autophagy. Although autophagy often accompanies cell death…”
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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Autor Aubrey, Brandon J, Kelly, Gemma L, Janic, Ana, Herold, Marco J, Strasser, Andreas

“…The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the…”
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Targeting mitochondrial metabolism for precision medicine in cancer Autor Sainero-Alcolado, Lourdes, Liaño-Pons, Judit, Ruiz-Pérez, María Victoria, Arsenian-Henriksson, Marie

“…During decades, the research field of cancer metabolism was based on the Warburg effect, described almost one century ago. Lately, the key role of mitochondria…”
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Cell death and inflammation during obesity: "Know my methods, WAT(son)" Autor Hildebrandt, Ximena, Ibrahim, Mohamed, Peltzer, Nieves

“…Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF family…”
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Cuproptosis: p53-regulated metabolic cell death? Autor Xiong, Chen, Ling, Hong, Hao, Qian, Zhou, Xiang

“…Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that utilize oxidative phosphorylation as the main metabolic pathway to…”
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Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA Autor Zhang, Ying, Luo, Meiying, Cui, Xiaohong, O'Connell, Douglas, Yang, Yongfei

“…Ferroptosis, a novel form of regulated cell death induced by iron-dependent lipid peroxidation, plays an essential role in the development and drug resistance…”
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Patients with COVID-19: in the dark-NETs of neutrophils Autor Ackermann, Maximilian, Anders, Hans-Joachim, Bilyy, Rostyslav, Bowlin, Gary L, Daniel, Christoph, De Lorenzo, Rebecca, Egeblad, Mikala, Henneck, Timo, Hidalgo, Andrés, Hoffmann, Markus, Hohberger, Bettina, Kanthi, Yogendra, Kaplan, Mariana J, Knight, Jason S, Knopf, Jasmin, Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Mahajan, Aparna, Manfredi, Angelo A, Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Muñoz, Luis E, Narasaraju, Teluguakula, Naschberger, Elisabeth, Neeli, Indira, Ng, Lai Guan, Radic, Marko Z, Ritis, Konstantinos, Rovere-Querini, Patrizia, Schapher, Mirco, Schauer, Christine, Simon, Hans-Uwe, Singh, Jeeshan, Skendros, Panagiotis, Stark, Konstantin, Stürzl, Michael, van der Vlag, Johan, Vandenabeele, Peter, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yanginlar, Cansu, Yousefi, Shida, Zarbock, Alexander, Schett, Georg, Herrmann, Martin

“…SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs, occasionally causing death. Until effective vaccines are developed to curb…”
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Cell cycle regulation: p53-p21-RB signaling Autor Engeland, Kurt

“…The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both…”
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Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities Autor Schmidt, Marlene F, Gan, Zhong Yan, Komander, David, Dewson, Grant

“…Neurodegenerative diseases are characterised by progressive damage to the nervous system including the selective loss of vulnerable populations of neurons…”
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Ferroptosis: process and function Autor Xie, Y, Hou, W, Song, X, Yu, Y, Huang, J, Sun, X, Kang, R, Tang, D

“…Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with…”
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Autophagy and disease: unanswered questions Autor Yang, Ying, Klionsky, Daniel J

“…Autophagy is a process in which intracellular components and dysfunctional organelles are delivered to the lysosome for degradation and recycling. Autophagy…”
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