Výsledky vyhľadávania - "Cell death & disease"

Autophagy: Regulator of cell death Autor Liu, ShiZuo, Yao, ShuaiJie, Yang, Huan, Liu, ShuaiJie, Wang, YanJiao

“…Autophagy is the process by which cells degrade and recycle proteins and organelles to maintain intracellular homeostasis. Generally, autophagy plays a…”
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Ferroptosis: past, present and future Autor Li, Jie, Cao, Feng, Yin, He-liang, Huang, Zi-jian, Lin, Zhi-tao, Mao, Ning, Sun, Bei, Wang, Gang

“…Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid…”
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Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction Autor Calabresi, Paolo, Mechelli, Alessandro, Natale, Giuseppina, Volpicelli-Daley, Laura, Di Lazzaro, Giulia, Ghiglieri, Veronica

“…Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) is now twenty-five years old, it still…”
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Detection of immunogenic cell death and its relevance for cancer therapy Autor Fucikova, Jitka, Kepp, Oliver, Kasikova, Lenka, Petroni, Giulia, Yamazaki, Takahiro, Liu, Peng, Zhao, Liwei, Spisek, Radek, Kroemer, Guido, Galluzzi, Lorenzo

“…Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely…”
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The interaction between ferroptosis and inflammatory signaling pathways Autor Chen, Yue, Fang, Ze-Min, Yi, Xin, Wei, Xiang, Jiang, Ding-Sheng

“…Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological event that…”
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RNA-based therapeutics: an overview and prospectus Autor Zhu, Yiran, Zhu, Liyuan, Wang, Xian, Jin, Hongchuan

“…The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto…”
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The diversified role of mitochondria in ferroptosis in cancer Autor Liu, Yu’e, Lu, Shiping, Wu, Lei-lei, Yang, Liang, Yang, Lixue, Wang, Jinghan

“…Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012…”
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Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Autor Kou, Meng, Huang, Li, Yang, Jinjuan, Chiang, Zhixin, Chen, Shaoxiang, Liu, Jie, Guo, Liyan, Zhang, Xiaoxian, Zhou, Xiaoya, Xu, Xiang, Yan, Xiaomei, Wang, Yan, Zhang, Jinqiu, Xu, Aimin, Tse, Hung-fat, Lian, Qizhou

“…Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for…”
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PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers Autor Liu, Rui, Chen, Youwen, Liu, Guangzhi, Li, Chenxi, Song, Yurong, Cao, Zhiwen, Li, Wen, Hu, Jinghong, Lu, Cheng, Liu, Yuanyan

“…Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that…”
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Advances in the pathogenesis of psoriasis: from keratinocyte perspective Autor Zhou, Xue, Chen, Youdong, Cui, Lian, Shi, Yuling, Guo, Chunyuan

“…Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and…”
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Oxidative cell death in cancer: mechanisms and therapeutic opportunities Autor An, Xiaoqin, Yu, Wenfeng, Liu, Jinbao, Tang, Daolin, Yang, Li, Chen, Xin

“…Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism…”
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Regulated cell death pathways in doxorubicin-induced cardiotoxicity Autor Christidi, Effimia, Brunham, Liam R.

“…Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has…”
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Stromal cells in the tumor microenvironment: accomplices of tumor progression? Autor Zhao, Yan, Shen, Meili, Wu, Liangqiang, Yang, Haiqin, Yao, Yixuan, Yang, Qingbiao, Du, Jianshi, Liu, Linlin, Li, Yapeng, Bai, Yuansong

“…The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and…”
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Mutant p53 in cancer: from molecular mechanism to therapeutic modulation Autor Chen, Xiaohua, Zhang, Taotao, Su, Wei, Dou, Zhihui, Zhao, Dapeng, Jin, Xiaodong, Lei, Huiwen, Wang, Jing, Xie, Xiaodong, Cheng, Bo, Li, Qiang, Zhang, Hong, Di, Cuixia

“…TP53 , a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53…”
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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors Autor Yang, Yang, Wang, Huanan, Kouadir, Mohammed, Song, Houhui, Shi, Fushan

“…The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines…”
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ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation Autor Park, Eunhee, Chung, Su Wol

“…Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death…”
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Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease Autor Li, Anqi, Gao, Meng, Liu, Bilin, Qin, Yuan, chen, Lei, Liu, Hanyu, Wu, Huayan, Gong, Guohua

“…Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and apoptosis…”
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The role of pyroptosis in cancer: pro-cancer or pro-“host”? Autor Xia, Xiaojing, Wang, Xin, Cheng, Zhe, Qin, Wanhai, Lei, Liancheng, Jiang, Jinqing, Hu, Jianhe

“…Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy, and…”
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Endoplasmic reticulum stress-mediated cell death in liver injury Autor Zhang, Jian, Guo, Jiafu, Yang, Nannan, Huang, Yan, Hu, Tingting, Rao, Chaolong

“…The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum…”
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Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? Autor Rada, Patricia, González-Rodríguez, Águeda, García-Monzón, Carmelo, Valverde, Ángela M.

“…Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to…”
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