Suchergebnisse - "Cell cycle (Georgetown, Tex.)"

The double dealing of cyclin D1 von Tchakarska, Guergana, Sola, Brigitte

“… The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts …”
Volltext

Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis von Zheng, Zhaodi, Bian, Yan, Zhang, Yang, Ren, Guanghui, Li, Guorong

“… Pyroptosis is a form of programmed cell death initiated by inflammasomes and is critical for immunity. SIRT1, a NAD+-dependent deacetylase, plays multiple …”
Volltext

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer von Mu, Xianmin, Shi, Wei, Xu, Yue, Xu, Che, Zhao, Ting, Geng, Biao, Yang, Jing, Pan, Jinshun, Hu, Shi, Zhang, Chen, Zhang, Juan, Wang, Chao, Shen, Jiajia, Che, Yin, Liu, Zheng, Lv, Yuanfang, Wen, Hao, You, Qiang

“… Tumor-associated macrophages (TAM) are prominent components of tumor microenvironment (TME) and capable of promoting cancer progression. However, the …”
Volltext

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis von Liu, Yubao, Lin, Lupan, Zou, Rui, Wen, Chuanyang, Wang, Zhen, Lin, Fuqing

“… Background: Exosomes secreted by human mesenchymal stem cells (hMSCs) have been shown to promote cartilage regeneration. This study aimed to explore whether …”
Volltext

Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages von An, Zhujun, Li, Jiawen, Yu, Jiangbo, Wang, Xiaoli, Gao, Hailai, Zhang, Wei, Wei, Zeren, Zhang, Jianchun, Zhang, Yinli, Zhao, Jiyi, Liang, Xiao

“… Here, we sought to explore the underlying role of interleukin (IL)-8 in neutrophil extracellular traps (NETs) formation during atherosclerosis (AS). The …”
Volltext

MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway von Ju, MinJie, Liu, BoFei, He, HongYu, Gu, ZhunYong, Liu, YiMei, Su, Ying, Zhu, DuMing, Cang, Jing, Luo, Zhe

“… Acute lung injury (ALI) is a critical clinical condition with a high mortality rate, characterized with excessive uncontrolled inflammation and apoptosis …”
Volltext

Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events von McCloy, Rachael A, Rogers, Samuel, Caldon, C Elizabeth, Lorca, Thierry, Castro, Anna, Burgess, Andrew

“… Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low …”
Volltext

Molecular mechanisms for ABCA1-mediated cholesterol efflux von Chen, Lei, Zhao, Zhen-Wang, Zeng, Peng-Hui, Zhou, Ying-Jie, Yin, Wen-Jun

“… The maintenance of cellular cholesterol homeostasis is essential for normal cell function and viability. Excessive cholesterol accumulation is detrimental to …”
Volltext

CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression von Chen, Daishi, Ma, Wei, Ke, Zhaoyang, Xie, Fei

“… Circular RNA (circRNA) is shown to participate in various tumors, including lung cancer. Although a few circRNAs involved in lung cancer are reported, whether …”
Volltext

Protective effect of berberine against LPS-induced injury in the intestine: a review von Izadparast, Faezeh, Riahi-Zajani, Bamdad, Yarmohammadi, Fatemeh, Hayes, A. Wallace, Karimi, Gholamreza

“… Sepsis is a systemic inflammatory condition caused by an unbalanced immunological response to infection, which affects numerous organs, including the …”
Volltext

Autophagy and apoptosis in liver injury von Wang, Kewei

“… Apoptosis is a primary characteristic in the pathogenesis of liver disease. Hepatic apoptosis is regulated by autophagic activity. However, mechanisms …”
Volltext

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways von Feng, Chencheng, Liu, Huan, Yang, Minghui, Zhang, Yang, Huang, Bo, Zhou, Yue

“… The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests the detrimental roles of cell senescence in the pathogenesis of …”
Volltext

4E-BP1, a multifactor regulated multifunctional protein von Qin, Xiaoyu, Jiang, Bin, Zhang, Yanjie

“… Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known …”
Volltext

Targeting the cell cycle in breast cancer: towards the next phase von Thu, KL, Soria-Bretones, I, Mak, TW, Cescon, DW

“… Deregulation of the cell cycle is a hallmark of cancer that enables limitless cell division. To support this malignant phenotype, cells acquire molecular …”
Volltext

miR-29c-3p inhibits autophagy and cisplatin resistance in ovarian cancer by regulating FOXP1/ATG14 pathway von Hu, Zhenhua, Cai, Mingbo, Zhang, Ying, Tao, Lingling, Guo, Ruixia

“… Autophagy, characterized by the elevator of autophagy-related gene 14 (ATG14) and the dysregulation of autophagy-related proteins, contributes to the cisplatin …”
Volltext

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1 von Zhang, Yilei, Koppula, Pranavi, Gan, Boyi

“… SLC7A11 (or xCT) imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis. SLC7A11 expression is tightly …”
Volltext

Exosomes derived from oxLDL-stimulated macrophages induce neutrophil extracellular traps to drive atherosclerosis von Zhang, Yong-Gan, Song, Yan, Guo, Xue-Li, Miao, Ren-Ying, Fu, Yi-Qun, Miao, Chao-Feng, Zhang, Chuang

“… This study aimed to investigate the role and underlying mechanism of exosomes secreted by oxidized low-density lipoprotein (oxLDL)-stimulated macrophages in …”
Volltext

Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway von Jiang, Zhensong, Zhang, Jianru

“… EXs (Exosomes) secreted by mesenchymal stem cells (MSCs) have the potential to treat spinal cord injury (SCI), this study aimed to further explore the …”
Volltext

HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways von Lei, Rui, Li, Jian, Liu, Feng, Li, Weihan, Zhang, Shizhen, Wang, Yang, Chu, Xi, Xu, Jinghong

“… A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often …”
Volltext

YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells von Chen, Jixiang, Sun, Yaocheng, Xu, Xiao, Wang, Dawei, He, Junbo, Zhou, Hailang, Lu, Ying, Zeng, Jian, Du, Fengyi, Gong, Aihua, Xu, Min

“… Recent studies show that YTH domain family 2 (YTHDF2) preferentially binds to m A-containing mRNA regulates localization and stability of the bound mRNA …”
Volltext