Search Results - "Cell biochemistry and function"

The PROTAC technology in drug development by Zou, Yutian, Ma, Danhui, Wang, Yinyin

“…Currently, a new technology termed PROTAC, proteolysis targeting chimera, has been developed for inducing the protein degradation by a targeting molecule. This…”
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Cell viability and cytotoxicity assays: Biochemical elements and cellular compartments by Khalef, Lefsih, Lydia, Radja, Filicia, Khettar, Moussa, Berkoud

“…Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of…”
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ATG5: A central autophagy regulator implicated in various human diseases by Changotra, Harish, Kaur, Sargeet, Yadav, Suresh Singh, Gupta, Girdhari Lal, Parkash, Jyoti, Duseja, Ajay

“…Autophagy, an intracellular conserved degradative process, plays a central role in the renewal/recycling of a cell to maintain the homeostasis of nutrients and…”
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Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight by Singh, Rahul, Bhardwaj, Vijay K., Purohit, Rituraj

“…The quick widespread of the coronavirus and speedy upsurge in the tally of cases demand the fast development of effective drugs. The uridine‐directed…”
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A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment by Gunata, Mehmet, Parlakpinar, Hakan

“…Cardiovascular diseases are known to be the most fatal diseases worldwide. Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most…”
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Semaglutide (GLP‐1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice by Martins, Fabiane F., Marinho, Thatiany S., Cardoso, Luiz E. M., Barbosa‐da‐Silva, Sandra, Souza‐Mello, Vanessa, Aguila, Marcia B., Mandarim‐de‐Lacerda, Carlos A.

“…Semaglutide (GLP‐1 agonist) was approved for treating obesity. Although the effects on weight loss and metabolism are known, the responses of adipocytes to…”
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Phenolic compounds as antidiabetic, anti‐inflammatory, and anticancer agents and improvement of their bioavailability by liposomes by Tatipamula, Vinay Bharadwaj, Kukavica, Biljana

“…Phenolic compounds, widespread in plants, are a necessary part of the human regimen due to their antioxidant and pro‐oxidative properties. Naturally, phenolics…”
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Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges by Ahmadi, Mahdi, Rezaie, Jafar

“…Ageing induces a great risk factor that participates in progressing various degenerative diseases morbidities. The main characteristic of ageing is the failure…”
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Computational targeting of allosteric site of MEK1 by quinoline‐based molecules by Singh, Rahul, Bhardwaj, Vijay K., Purohit, Rituraj

“…MEK1 is an attractive target due to its role in selective extracellular‐signal‐regulated kinase phosphorylation, which plays a pivotal role in regulating cell…”
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Photobiomodulation in diabetic wound healing: A review of red and near‐infrared wavelength applications by Oyebode, Olajumoke, Houreld, Nicolette Nadene, Abrahamse, Heidi

“…The development of a painless, non‐invasive, and faster way to diabetic wound healing is at the forefront of research. The complexity associated with diabetic…”
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Gold nanoparticles–conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt–mediated pathway in breast cancer cell lines (MCF‐7 and MDA‐MB‐231) by Balakrishnan, Solaimuthu, Mukherjee, Sudip, Das, Sourav, Bhat, Firdous Ahmad, Raja Singh, Paulraj, Patra, Chitta Ranjan, Arunakaran, Jagadeesan

“…Epidermal growth factor plays a major role in breast cancer cell proliferation, survival, and metastasis. Quercetin, a bioactive flavonoid, is shown to exhibit…”
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Macrophage efferocytosis in health and disease by Razi, Shokufeh, Yaghmoorian Khojini, Javad, Kargarijam, Fateme, Panahi, Susan, Tahershamsi, Zahra, Tajbakhsh, Amir, Gheibihayat, Seyed Mohammad

“…Creating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris…”
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NF‐κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation by Zamanian, Mohammad Yasin, Alsaab, Hashem O., Golmohammadi, Maryam, Yumashev, Alexey, Jabba, Abeer Mhussan, Abid, Mohammed Kadhem, Joshi, Abhishek, Alawadi, Ahmed Hussien, Jafer, Noor S., Kianifar, Farzaneh, Obakiro, Samuel Baker

“…Diabetes mellitus (DM) is a collection of metabolic disorder that is characterized by chronic hyperglycemia. Recent studies have demonstrated the crucial…”
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The role of Shh signalling pathway in central nervous system development and related diseases by Li, Xiaoying, Li, Yunxiao, Li, Shuanqing, Li, Han, Yang, Ciqing, Lin, Juntang

“…Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh…”
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Knockdown XIST alleviates LPS‐induced WI‐38 cell apoptosis and inflammation injury via targeting miR‐370‐3p/TLR4 in acute pneumonia by Zhang, Yena, Zhu, Yuyin, Gao, Guosheng, Zhou, Zhiming

“…Pneumonia is an inflammatory disease that occurs in the lungs associated with pathogens or other factors. It has been well established that long noncoding RNA…”
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Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders by Nezhad Salari, Amir Mohammad, Rasoulizadeh, Zahra, Shabgah, Arezoo Gowhari, Vakili‐Ghartavol, Roghayyeh, Sargazi, Ghasem, Gholizadeh Navashenaq, Jamshid

“…Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential…”
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Recent progress of atmospheric and room‐temperature plasma as a new and promising mutagenesis technology by Li, Dongao, Shen, Jie, Ding, Qiang, Wu, Jinyong, Chen, Xiangsong

“…At present, atmospheric and room‐temperature plasma (ARTP) is regarded as a new and powerful mutagenesis technology with the advantages of…”
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CircRNA‐0077930 from hyperglycaemia‐stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells by Wang, Sha, Zhan, Junkun, Lin, Xiao, Wang, Yanjiao, Wang, Yi, Liu, Youshuo

“…Vascular smooth muscle aging leads to diabetic complications such as cardiovascular and kidney diseases or diabetic foot. Therefore, understanding the…”
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The use of erythrocyte fragility to assess xenobiotic cytotoxicity by Pagano, Maria, Faggio, Caterina

“…The erythrocytes of mammals represent a good model to evaluate the cytotoxicity of molecules, organic and inorganic, natural or synthetic, by cellular damage…”
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The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances by Khorasani, Ayda Baghery Saghchy, Hafezi, Nasim, Sanaei, Mohammad‐Javad, Jafari‐Raddani, Farideh, Pourbagheri‐Sigaroodi, Atieh, Bashash, Davood

“…Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer mortality in women. As the phosphatidylinositol 3‐kinase (PI3K)…”
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