Suchergebnisse - "Cell Movement"

A mathematical model of cell movement and clustering due to chemotaxis von Farmer, Adam, Harris, Paul J.

“… on the cell’s membrane and on the boundary of the cell’s nucleus. The nodes located on a cell’s membrane are subject to a force which is proportional to the gradient …”
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Cell stiffness determined by atomic force microscopy and its correlation with cell motility von Luo, Qing, Kuang, Dongdong, Zhang, Bingyu, Song, Guanbin

“… Cell stiffness is a crucial mechanical property that is closely related to cell motility. AFM is the most prevalent method used to determine cell stiffness by …”
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Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts von Fay, Meredith E, Myers, David R, Kumar, Amit, Turbyfield, Cory T, Byler, Rebecca, Crawford, Kaci, Mannino, Robert G, Laohapant, Alvin, Tyburski, Erika A, Sakurai, Yumiko, Rosenbluth, Michael J, Switz, Neil A, Sulchek, Todd A, Graham, Michael D, Lam, Wilbur A

“… First, we found that the proportions of granulocytes from healthy human subjects that traversed and demarginated from microfluidic models of capillary beds and veins, respectively, increased …”
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Neutrophil functions in morbidly obese subjects von Brotfain, E., Hadad, N., Shapira, Y., Avinoah, E., Zlotnik, A., Raichel, L., Levy, R.

“… Summary The present study aimed to determine different peripheral blood neutrophil functions in 18 morbidly obese subjects with body mass index (BMI …”
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Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor von Wu, Jing-Yiing, Huang, Tsai-Wang, Hsieh, Yi-Ting, Wang, Yi-Fu, Yen, Chia-Chien, Lee, Guan-Lin, Yeh, Chang-Ching, Peng, Yi-Jen, Kuo, Ya-Yi, Wen, Hsiu-Ting, Lin, Hui-Chen, Hsiao, Cheng-Wen, Wu, Kenneth K, Kung, Hsing-Jien, Hsu, Yu-Juei, Kuo, Cheng-Chin

“… These effects are mediated by SUCNR1-triggered PI3K-hypoxia-inducible factor 1α (HIF-1α) axis. Compared with healthy subjects and tumor-free lung tissues, serum succinate …”
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Functional analysis of miR-21-3p, miR-30b-5p and miR-150-5p shuttled by extracellular vesicles from diabetic subjects reveals their association with diabetic retinopathy von Mazzeo, Aurora, Lopatina, Tatiana, Gai, Chiara, Trento, Marina, Porta, Massimo, Beltramo, Elena

“… In this work, we further characterized EVs from subjects with diabetic retinopathy and investigated miR-150-5p, miR-21-3p and miR-30b-5p …”
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Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells von Wu, Yuan Seng, Chung, Ivy, Wong, Won Fen, Masamune, Atsushi, Sim, Maw Shin, Looi, Chung Yeng

“… We previously showed that pancreatic stellate cells (PSC) secreted interleukin (IL)-6 and promoted pancreatic ductal adenocarcinoma (PDAC) cell proliferation …”
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Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer von Bhattacharjee, Mousumi, Upadhyay, Priyanka, Sarker, Sushmita, Basu, Arijita, Das, Shaswati, Ghosh, Avijit, Ghosh, Swatilekha, Adhikary, Arghya

“… Breast cancer intimidates the contemporary medical advances, attempting to revolutionize cancer therapeutics. While patients suffering an advanced breast …”
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New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies von Elkady, Hazem, Mahdy, Hazem A., Taghour, Mohammed S., Dahab, Mohammed A., Elwan, Alaa, Hagras, Mohamed, Hussein, Mona H., Ibrahim, Ibrahim M., Husein, Dalal Z., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.

“… VEGFR-2 has emerged as a prominent positive regulator of cancer progression. Discovery of new anticancer agents and apoptotic inducers targeting VEGFR-2 …”
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IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation von Impellizzieri, Daniela, Ridder, Frederike, Raeber, Miro E., Egholm, Cecilie, Woytschak, Janine, Kolios, Antonios G.A., Legler, Daniel F., Boyman, Onur

“… ) CXCR1, CXCR2, and CXCR4 expression, as well as (5) in nonallergic versus allergic subjects …”
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Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects von Namour, Florence, Galien, René, Van Kaem, Tim, Van der Aa, Annegret, Vanhoutte, Frédéric, Beetens, Johan, Klooster, Gerben

“… Methods Two consecutive randomized, double‐blind, placebo‐controlled, single centre trials in healthy subjects were performed …”
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IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma von Salter, Brittany M., Oliveria, John Paul, Nusca, Graeme, Smith, Steve G., Tworek, Damian, Mitchell, Patrick D., Watson, Rick M., Sehmi, Roma, Gauvreau, Gail M.

“… Background The alarmin cytokines IL-25 and IL-33 are key promoters of type 2 inflammation. Basophils respond to alarmin cytokines, however the relationship of …”
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P2X7 receptor contributes to DNA damage repair and acquisition of malignant phenotypes in irradiated human glioblastoma cells von Seki, Hiromu, Kitabatake, Kazuki, Uchiumi, Fumiaki, Tanuma, Sei-ichi, Tsukimoto, Mitsutoshi

“… Radiation therapy for cancer takes advantage of the higher sensitivity of tumor cells to radiation compared to normal tissue, but some cancers, such as …”
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Inhibition of phosphodiesterase 4 and 7 regulates breast cancer cell proliferation von Mayora Justel, Carla, Valladares, Tamara, Gargiulo, Lucía, González-Pardo, Verónica, De Sousa, Maximiliano, Esandi, María del Carmen, Davio, Carlos, Lüthy, Isabel, Bruzzone, Ariana

“… cAMP regulates key processes in mammary cell biology. Previous studies suggested reduced cAMP production in more malignant cells. This study investigates the …”
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Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout von Grainger, Rebecca, McLaughlin, Rene J, Harrison, Andrew A, Harper, Jacquie L

“… Whole blood was collected from subjects with a history of acute or chronic gout but not currently experiencing an attack of gout, subjects with asymptomatic hyperuricaemia and healthy individuals with normouricaemia …”
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Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers von Theocharidis, Georgios, Baltzis, Dimitrios, Roustit, Matthieu, Tellechea, Ana, Dangwal, Seema, Khetani, Radhika S, Shu, Bin, Zhao, Wanni, Fu, Jianfang, Bhasin, Swati, Kafanas, Antonios, Hui, Daniel, Sui, Shannan Ho, Patsopoulos, Nikolaos A, Bhasin, Manoj, Veves, Aristidis

“… ) and DFU specimens compared with control subjects. In addition, in myeloid cell DM and DFU upstream regulator analysis, we observed …”
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Cell jamming: Collective invasion of mesenchymal tumor cells imposed by tissue confinement von Haeger, Anna, Krause, Marina, Wolf, Katarina, Friedl, Peter

“… Cancer invasion is a multi-step process which coordinates interactions between tumor cells with mechanotransduction towards the surrounding matrix, resulting …”
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Involvement of RAGE in radiation-induced acquisition of malignant phenotypes in human glioblastoma cells von Seki, Hiromu, Kitabatake, Kazuki, Tanuma, Sei-ichi, Tsukimoto, Mitsutoshi

“… Glioblastoma (GBM), a highly aggressive malignant tumor of the central nervous system, is mainly treated with radiotherapy. However, since irradiation may lead …”
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Hyaluronic acid engrafted metformin loaded graphene oxide nanoparticle as CD44 targeted anti-cancer therapy for triple negative breast cancer von Basu, Arijita, Upadhyay, Priyanka, Ghosh, Avijit, Bose, Aparajita, Gupta, Payal, Chattopadhyay, Sreya, Chattopadhyay, Dipankar, Adhikary, Arghya

“… Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer with limited treatment modalities. It is associated with high propensity of …”
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Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans von van der Valk, Fleur M, Bekkering, Siroon, Kroon, Jeffrey, Yeang, Calvin, Van den Bossche, Jan, van Buul, Jaap D, Ravandi, Amir, Nederveen, Aart J, Verberne, Hein J, Scipione, Corey, Nieuwdorp, Max, Joosten, Leo A B, Netea, Mihai G, Koschinsky, Marlys L, Witztum, Joseph L, Tsimikas, Sotirios, Riksen, Niels P, Stroes, Erik S G

“… Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its pathogenicity are …”
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