Suchergebnisse - "Cell Cycle Checkpoints - genetics"

Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer von Chen, Xin, Chen, Zhenyao, Yu, Shanxun, Nie, Fengqi, Yan, Shuai, Ma, Pei, Chen, Qinnan, Wei, Chenchen, Fu, Hangjiang, Xu, Tianwei, Ren, Shengnan, Sun, Ming, Wang, Zhaoxia

“… Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases, including cancers. However, the overall biological roles and …”
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DNA repair dysregulation from cancer driver to therapeutic target von Curtin, Nicola J.

“… DNA is subject to a high level of endogenous damage and the DDR is essential for the maintenance of genomic stability and survival …”
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Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells von Holland, Andrew J, Fachinetti, Daniele, Han, Joo Seok, Cleveland, Don W

“… Inducible degradation is a powerful approach for identifying the function of a specific protein or protein complex. Recently, a plant auxin-inducible degron …”
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DNA damage checkpoints in stem cells, ageing and cancer von Sperka, Tobias, Wang, Jianwei, Rudolph, K. Lenhard

“… Key Points Checkpoint responses have diverse roles in adult stem cells depending on the genetic context and the level of DNA damage in tissues and stem cells, …”
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Multiscale effects of heating and cooling on genes and gene networks von Charlebois, Daniel A, Hauser, Kevin, Marshall, Sylvia, Balázsi, Gábor

“… Most organisms must cope with temperature changes. This involves genes and gene networks both as subjects and agents of cellular protection, creating difficulties in understanding …”
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A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint von Benzi, Giorgia, Camasses, Alain, Atsunori, Yoshimura, Katou, Yuki, Shirahige, Katsuhiko, Piatti, Simonetta

“… The Mps1 kinase corrects improper kinetochore–microtubule attachments, thereby ensuring chromosome biorientation. Yet, its critical phosphorylation targets in …”
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Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma von Harada, Eriko, Yoshida, Saishu, Imaizumi, Yuta, Kawamura, Akira, Ohtsuka, Takashi, Yoshida, Kiyotsugu

“… Lung cancer is a leading cause of cancer-related mortality and remains one of the most poorly prognosed disease worldwide. Therefore, it is necessary to …”
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Spatial control of nucleoporin condensation by fragile X‐related proteins von Agote‐Aran, Arantxa, Schmucker, Stephane, Jerabkova, Katerina, Jmel Boyer, Inès, Berto, Alessandro, Pacini, Laura, Ronchi, Paolo, Kleiss, Charlotte, Guerard, Laurent, Schwab, Yannick, Moine, Hervé, Mandel, Jean‐Louis, Jacquemont, Sebastien, Bagni, Claudia, Sumara, Izabela

“… Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve‐like hydrogel within …”
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Deficiency of miR-155 in Leukemic B-Cells Results in Cell Cycle Arrest and Deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network von Golovina, Elena, Kokavec, Juraj, Kazantsev, Dmitry, Yurikova, Oxana, Bajecny, Martin, Savvulidi, Filipp Georgijevic, Simersky, Radim, Lenobel, Rene, Tost, Jorg, Herynek, Vit, Sefc, Ludek, Sebela, Marek, Klener, Pavel, Zemanova, Zuzana, Stopka, Tomas, Vargova, Karina Savvulidi

“… ), which is overexpressed in malignancies including chronic lymphocytic leukemia (CLL). Nonetheless, the precise mechanism of how miR-155 regulates the cell cycle in leukemic cells remains the subject of extensive research …”
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Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint von Cantaert, Tineke, Schickel, Jean-Nicolas, Bannock, Jason M., Ng, Yen-Shing, Massad, Christopher, Delmotte, Fabien R., Yamakawa, Natsuko, Glauzy, Salome, Chamberlain, Nicolas, Kinnunen, Tuure, Menard, Laurence, Lavoie, Aubert, Walter, Jolan E., Notarangelo, Luigi D., Bruneau, Julie, Al-Herz, Waleed, Kilic, Sara Sebnem, Ochs, Hans D., Cunningham-Rundles, Charlotte, van der Burg, Mirjam, Kuijpers, Taco W., Kracker, Sven, Kaneko, Hideo, Sekinaka, Yujin, Nonoyama, Shigeaki, Durandy, Anne, Meffre, Eric

“… The low frequency of autoreactive mature naive B cells in UNG-deficient patients resembled that of healthy subjects, revealing that impaired CSR does not interfere with the peripheral B cell tolerance checkpoint …”
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Rif1 Regulates Initiation Timing of Late Replication Origins throughout the S. cerevisiae Genome von Peace, Jared M., Ter-Zakarian, Anna, Aparicio, Oscar M.

“… Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-phase …”
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Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells von Chen, Qian, Jiang, Sijia, Liu, Haihua, Gao, Yue, Yang, Xiaoxue, Ren, Zhonglu, Gao, Yunfei, Xiao, Lu, Hu, Haoyue, Yu, Yanhong, Yang, Xinping, Zhong, Mei

“… the underlying molecular mechanism remains unclear. We carried out transcriptome profiling on placentae from preeclamptic patients and normal subjects, and identified about four hundred long non-coding RNAs differentially expressed in placentae …”
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The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer von Su, Linna, Liu, Xiangqiang, Chai, Na, Lv, Lifen, Wang, Rui, Li, Xiaosa, Nie, Yongzhan, Shi, Yongquan, Fan, Daiming

“… Background FOXO4, a member of the FOXO family of transcription factors, is currently the focus of intense study. Its role and function in gastric cancer have …”
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MicroRNA-218 inhibits the malignant phenotypes of glioma by modulating the TNC/AKT/AP-1/TGFβ1 feedback signaling loop von Dang, Siwen, Zhang, Rui, Tian, Sijia, Hou, Peng, Li, Gang, Ji, Meiju

“… in gliomas remains largely unknown miR-218 expression was analyzed in gliomas and normal brain tissues (control subjects …”
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CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin von Chen, Juan, Jiang, Chen, Fu, Li, Zhu, Cai-Lei, Xiang, Yan-Qun, Jiang, Ling-Xi, Chen, Qian, Liu, Wai Man, Chen, Jin-Na, Zhang, Li-Yi, Liu, Ming, Chen, Chao, Tang, Hong, Wang, Bo, Tsao, Sai Wah, Kwong, Dora Lai-Wan, Guan, Xin-Yuan

“… Deletion of Chromosome 3p is one of the most frequently detected genetic alterations in nasopharyngeal carcinoma (NPC). We reported the role of a novel 3p26.3 …”
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FOXO3a Activation by HDAC Class IIa Inhibition Induces Cell Cycle Arrest in Pancreatic Cancer Cells von Usami, Makoto, Kikuchi, Shohei, Takada, Kohichi, Ono, Michihiro, Sugama, Yusuke, Arihara, Yohei, Hayasaka, Naotaka, Nakamura, Hajime, Ikeda, Yuuki, Hirakawa, Masahiro, Yoshida, Makoto, Miyanishi, Koji, Kobune, Masayoshi, Kato, Junji

“… Pancreatic cancer (PC) is highly aggressive with multiple oncogenic mutations. The efficacy of current chemotherapy is poor, and new therapeutic targets are …”
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Regulation of transcription and chromatin structure by pRB: Here, there and everywhere von Talluri, Srikanth, Dick, Frederick A.

“… The Retinoblastoma (RB) tumor suppressor pathway regulates this decision-making step. Since being the subject of Knudson's 'two hit hypothesis', there has been considerable interest in understanding pRB's role in cancer …”
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Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing von Pyo, Chul-Woong, Choi, Joon Hwan, Oh, Sang-Muk, Choi, Sang-Yun

“… Cyclin D1 is immediately down-regulated in response to reactive oxygen species (ROS) and implicated in the induction of cell cycle arrest in G2 phase by an …”
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Decreased RNA-binding protein IGF2BP2 downregulates NT5DC2, which suppresses cell proliferation, and induces cell cycle arrest and apoptosis in diffuse large B-cell lymphoma cells by regulating the p53 signaling pathway von Cui, Yuying, Wen, Yu, Lv, Chao, Zhao, Dongmei, Yang, Yu, Qiu, Hongbin, Wang, Chennan

“… Diffuse large B-cell lymphoma (DLBCL) remains difficult to treat clinically due to its highly aggressive characteristics. Insulin-like growth factor 2 …”
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Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer von Shi, Jing, Qu, Yiping, Li, Xinru, Sui, Fang, Yao, Demao, Yang, Qi, Shi, Bingyin, Ji, Meiju, Hou, Peng

“… ) assays, we investigated the expression and copy number of EHF in a cohort of gastric cancers and control subjects …”
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