Suchergebnisse - "Ceglia, Nicholas"

Reprogramming of the circadian clock by nutritional challenge von Eckel-Mahan, Kristin L, Patel, Vishal R, de Mateo, Sara, Orozco-Solis, Ricardo, Ceglia, Nicholas J, Sahar, Saurabh, Dilag-Penilla, Sherry A, Dyar, Kenneth A, Baldi, Pierre, Sassone-Corsi, Paolo

“… Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat diet (HFD) generates a profound reorganization of specific …”
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Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks von Dyar, Kenneth A, Lutter, Dominik, Artati, Anna, Ceglia, Nicholas J, Liu, Yu, Armenta, Danny, Jastroch, Martin, Schneider, Sandra, de Mateo, Sara, Cervantes, Marlene, Abbondante, Serena, Tognini, Paola, Orozco-Solis, Ricardo, Kinouchi, Kenichiro, Wang, Christina, Swerdloff, Ronald, Nadeef, Seba, Masri, Selma, Magistretti, Pierre, Orlando, Valerio, Borrelli, Emiliana, Uhlenhaut, N Henriette, Baldi, Pierre, Adamski, Jerzy, Tschöp, Matthias H, Eckel-Mahan, Kristin, Sassone-Corsi, Paolo

“… Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks …”
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Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling von Zhang, Allen W, O'Flanagan, Ciara, Chavez, Elizabeth A, Lim, Jamie L P, Ceglia, Nicholas, McPherson, Andrew, Wiens, Matt, Walters, Pascale, Chan, Tim, Hewitson, Brittany, Lai, Daniel, Mottok, Anja, Sarkozy, Clementine, Chong, Lauren, Aoki, Tomohiro, Wang, Xuehai, Weng, Andrew P, McAlpine, Jessica N, Aparicio, Samuel, Steidl, Christian, Campbell, Kieran R, Shah, Sohrab P

“… Single-cell RNA sequencing has enabled the decomposition of complex tissues into functionally distinct cell types. Often, investigators wish to assign cells to …”
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Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism von Masri, Selma, Rigor, Paul, Cervantes, Marlene, Ceglia, Nicholas, Sebastian, Carlos, Xiao, Cuiying, Roqueta-Rivera, Manuel, Deng, Chuxia, Osborne, Timothy F, Mostoslavsky, Raul, Baldi, Pierre, Sassone-Corsi, Paolo

“… Circadian rhythms are intimately linked to cellular metabolism. Specifically, the NAD(+)-dependent deacetylase SIRT1, the founding member of the …”
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Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses von O’Flanagan, Ciara H., Campbell, Kieran R., Zhang, Allen W., Kabeer, Farhia, Lim, Jamie L. P., Biele, Justina, Eirew, Peter, Lai, Daniel, McPherson, Andrew, Kong, Esther, Bates, Cherie, Borkowski, Kelly, Wiens, Matt, Hewitson, Brittany, Hopkins, James, Pham, Jenifer, Ceglia, Nicholas, Moore, Richard, Mungall, Andrew J., McAlpine, Jessica N., Shah, Sohrab P., Aparicio, Samuel

“… Background Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex biological systems, such as tumor heterogeneity and tissue …”
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Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle von Kinouchi, Kenichiro, Magnan, Christophe, Ceglia, Nicholas, Liu, Yu, Cervantes, Marlene, Pastore, Nunzia, Huynh, Tuong, Ballabio, Andrea, Baldi, Pierre, Masri, Selma, Sassone-Corsi, Paolo

“… The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. While food is a known …”
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Comparative Circadian Metabolomics Reveal Differential Effects of Nutritional Challenge in the Serum and Liver von Abbondante, Serena, Eckel-Mahan, Kristin L, Ceglia, Nicholas J, Baldi, Pierre, Sassone-Corsi, Paolo

“… Diagnosis and therapeutic interventions in pathological conditions rely upon clinical monitoring of key metabolites in the serum. Recent studies show that a …”
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Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake von Gaucher, Jonathan, Kinouchi, Kenichiro, Ceglia, Nicholas, Montellier, Emilie, Peleg, Shahaf, Greco, Carolina Magdalen, Schmidt, Andreas, Forne, Ignasi, Masri, Selma, Baldi, Pierre, Imhof, Axel, Sassone-Corsi, Paolo

“… Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been …”
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Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector von Ceglia, Nicholas, Sethna, Zachary, Freeman, Samuel S., Uhlitz, Florian, Bojilova, Viktoria, Rusk, Nicole, Burman, Bharat, Chow, Andrew, Salehi, Sohrab, Kabeer, Farhia, Aparicio, Samuel, Greenbaum, Benjamin D., Shah, Sohrab P., McPherson, Andrew

“… Deciphering individual cell phenotypes from cell-specific transcriptional processes requires high dimensional single cell RNA sequencing. However, current …”
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FOXA2 promotes metastatic competence in small cell lung cancer von Kawasaki, Kenta, Salehi, Sohrab, Zhan, Yingqian A., Chen, Kevin, Lee, Jun Ho, Salataj, Eralda, Zhong, Hong, Manoj, Parvathy, Kinyua, Dennis, Mello, Barbara P., Sridhar, Harsha, Tischfield, Sam E., Linkov, Irina, Ceglia, Nicholas, Zatzman, Matthew, Havasov, Eliyahu, Shah, Neil J., Meng, Fanli, Loomis, Brian, Bhanot, Umesh K., Redin, Esther, de Stanchina, Elisa, Hamard, Pierre-Jacques, Koche, Richard P., McPherson, Andrew, Quintanal-Villalonga, Álvaro, Shah, Sohrab P., Massagué, Joan, Rudin, Charles M.

“… Small cell lung cancer (SCLC) is known for its high metastatic potential, with most patients demonstrating clinically evident metastases in multiple organs at …”
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Accurate determination of CRISPR-mediated gene fitness in transplantable tumours von Eirew, Peter, O’Flanagan, Ciara, Ting, Jerome, Salehi, Sohrab, Brimhall, Jazmine, Wang, Beixi, Biele, Justina, Algara, Teresa, Lee, So Ra, Hoang, Corey, Yap, Damian, McKinney, Steven, Bates, Cherie, Kong, Esther, Lai, Daniel, Beatty, Sean, Andronescu, Mirela, Zaikova, Elena, Funnell, Tyler, Ceglia, Nicholas, Chia, Stephen, Gelmon, Karen, Mar, Colin, Shah, Sohrab, Roth, Andrew, Bouchard-Côté, Alexandre, Aparicio, Samuel

“… Assessing tumour gene fitness in physiologically-relevant model systems is challenging due to biological features of in vivo tumour regeneration, including …”
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Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception von Mazziotti, Raffaele, Baroncelli, Laura, Ceglia, Nicholas, Chelini, Gabriele, Sala, Grazia Della, Magnan, Christophe, Napoli, Debora, Putignano, Elena, Silingardi, Davide, Tola, Jonida, Tognini, Paola, Arthur, J. Simon C., Baldi, Pierre, Pizzorusso, Tommaso

“… MicroRNAs (miRNAs) are known to mediate post-transcriptional gene regulation, but their role in postnatal brain development is still poorly explored. We show …”
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SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity von Ioris, Rafael M., Galié, Mirco, Ramadori, Giorgio, Anderson, Jason G., Charollais, Anne, Konstantinidou, Georgia, Brenachot, Xavier, Aras, Ebru, Goga, Algera, Ceglia, Nicholas, Sebastián, Carlos, Martinvalet, Denis, Mostoslavsky, Raul, Baldi, Pierre, Coppari, Roberto

“… Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of …”
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Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1 von Sahar, Saurabh, Masubuchi, Satoru, Eckel-Mahan, Kristin, Vollmer, Simone, Galla, Luisa, Ceglia, Nicholas, Masri, Selma, Barth, Teresa K, Grimaldi, Benedetto, Oluyemi, Opeyemi, Astarita, Giuseppe, Hallows, William C, Piomelli, Daniele, Imhof, Axel, Baldi, Pierre, Denu, John M, Sassone-Corsi, Paolo

“… The circadian clock regulates a wide range of physiological and metabolic processes, and its disruption leads to metabolic disorders such as diabetes and …”
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Genome Architecture Mediates Transcriptional Control of Human Myogenic Reprogramming von Liu, Sijia, Chen, Haiming, Ronquist, Scott, Seaman, Laura, Ceglia, Nicholas, Meixner, Walter, Chen, Pin-Yu, Higgins, Gerald, Baldi, Pierre, Smale, Steve, Hero, Alfred, Muir, Lindsey A., Rajapakse, Indika

“… Genome architecture has emerged as a critical element of transcriptional regulation, although its role in the control of cell identity is not well understood …”
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524 Tim-4+ resident macrophages impair anti-tumor immunity in the serous body cavities By sequestering viable and cytotoxic CD8+ T cells expressing high levels of phosphatidylserine von Chow, Andrew, Schad, Sara, Green, Michael, Hellmann, Matthew, Ceglia, Nicholas, Allaj, Viola, Zago, Giulia, Shah, Nisarg, Sharma, Sai, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica, Qin, Angel, Balachandran, Vinod, Zou, Weiping, Shah, Sohrab, McPherson, Andrew, Panageas, Katherine, Lewis, Jason, Perry, Justin, Stanchina, Elisa de, Sen, Triparna, Poirier, John, Wolchok, Jedd, Rudin, Charles, Merghoub, Taha

“… BackgroundMalignant pleural effusions and peritoneal carcinomatosis are associated with poor outcomes in patients with cancer.1–3 Macrophages in these serous …”
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer von Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.

“… Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2 , 3 …”
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What time is it? Deep learning approaches for circadian rhythms von Agostinelli, Forest, Ceglia, Nicholas, Shahbaba, Babak, Sassone-Corsi, Paolo, Baldi, Pierre

“… Motivation: Circadian rhythms date back to the origins of life, are found in virtually every species and every cell, and play fundamental roles in functions …”
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CircadiOmics: circadian omic web portal von Ceglia, Nicholas, Liu, Yu, Chen, Siwei, Agostinelli, Forest, Eckel-Mahan, Kristin, Sassone-Corsi, Paolo, Baldi, Pierre

“… Abstract Circadian rhythms play a fundamental role at all levels of biological organization. Understanding the mechanisms and implications of circadian …”
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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer von Sethna, Zachary, Guasp, Pablo, Reiche, Charlotte, Milighetti, Martina, Ceglia, Nicholas, Patterson, Erin, Lihm, Jayon, Payne, George, Lyudovyk, Olga, Rojas, Luis A., Pang, Nan, Ohmoto, Akihiro, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Bruno, Emmanuel M., Zhang, Siqi Linsey, Cheng, Charlotte, Elhanati, Yuval, Derhovanessian, Evelyna, Manning, Luisa, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Merghoub, Taha, Wolchok, Jedd D., Basturk, Olca, Gönen, Mithat, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Soares, Kevin C., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Mellman, Ira, Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Balachandran, Vinod P.

“… A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex …”
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