Výsledky vyhľadávania - "Carlessi, Rodrigo"

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function Autor Rowlands, Jordan, Heng, Julian, Newsholme, Philip, Carlessi, Rodrigo

“…The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its "incretin effect" in restoring glucose homeostasis in diabetics, however, it is now…”
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Molecular mechanisms of ROS production and oxidative stress in diabetes Autor Newsholme, Philip, Cruzat, Vinicius Fernandes, Keane, Kevin Noel, Carlessi, Rodrigo, de Bittencourt, Jr, Paulo Ivo Homem

“…Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an…”
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Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis Autor Thapa, Dinesh, Patil, Mohan, Warne, Leon N., Carlessi, Rodrigo, Falasca, Marco

“…Current therapies for inflammatory bowel disease (IBD), such as olsalazine and cyclosporine, often exhibit limited long-term efficacy and are associated with…”
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Effects of vitamin D on primary human skeletal muscle cell proliferation, differentiation, protein synthesis and bioenergetics Autor Romeu Montenegro, Karina, Carlessi, Rodrigo, Cruzat, Vinicius, Newsholme, Philip

“…•Treatment with Vitamin D in primary human skeletal muscle cells.•Inhibited proliferation and increased differentiation process.•Additive effect on insulin…”
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Disease-associated hepatocytes are predictive of outcomes and survival in MASLD beyond fibrosis staging Autor Carlessi, Rodrigo, Kendall, Timothy James, Olynyk, John K, Dwyer, Benjamin J, Wallace, Michael C, Fallowfield, Jonathan A, Tirnitz-Parker, Janina Ee

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GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation Autor Carlessi, Rodrigo, Chen, Younan, Rowlands, Jordan, Cruzat, Vinicius F., Keane, Kevin N., Egan, Lauren, Mamotte, Cyril, Stokes, Rebecca, Gunton, Jenny E., Bittencourt, Paulo Ivo Homem de, Newsholme, Philip

“…Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by…”
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Enhancing Tetrahydrocannabinol’s Therapeutic Efficacy in Inflammatory Bowel Disease: The Roles of Cannabidiol and the Cannabinoid 1 Receptor Allosteric Modulator ZCZ011 Autor Thapa, Dinesh, Patil, Mohan, Warne, Leon N, Carlessi, Rodrigo, Falasca, Marco

“…Background/Objectives: Current inflammatory bowel disease (IBD) treatments focus on symptomatic relief, highlighting the need for innovative approaches…”
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Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations Autor Thapa, Dinesh, Patil, Mohan, Warne, Leon N, Carlessi, Rodrigo, Falasca, Marco

“…Cannabinoids are emerging as promising treatments for inflammatory diseases such as ulcerative colitis. Specifically, cannabinoid 2 (CB2) receptors, which are…”
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Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution Autor Cabanes-Creus, Marti, Navarro, Renina Gale, Liao, Sophia H.Y., Scott, Suzanne, Carlessi, Rodrigo, Roca-Pinilla, Ramon, Knight, Maddison, Baltazar, Grober, Zhu, Erhua, Jones, Matthew, Denisenko, Elena, Forrest, Alistair R.R., Alexander, Ian E., Tirnitz-Parker, Janina E.E., Lisowski, Leszek

“…Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical…”
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Human pancreatic islet transplantation: an update and description of the establishment of a pancreatic islet isolation laboratory Autor Rheinheimer, Jakeline, Bauer, Andrea C., Silveiro, Sandra P., Estivalet, Aline A. F., Bouças, Ana P., Rosa, Annelise R., Souza, Bianca M. de, Oliveira, Fernanda S. de, Cruz, Lavínia A., Brondani, Letícia A., Azevedo, Mirela J., Lemos, Natália E., Carlessi, Rodrigo, Assmann, Taís S., Gross, Jorge L., Leitão, Cristiane B., Crispim, Daisy

“…Type 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high morbidity and mortality rates in young adults of productive age…”
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Cloning and purification of recombinant proteins of Mycoplasma hyopneumoniae expressed in Escherichia coli Autor Simionatto, Simone, Marchioro, Silvana B., Galli, Vanessa, Hartwig, Daiane D., Carlessi, Rodrigo M., Munari, Fernanda M., Laurino, Jomar P., Conceição, Fabricio R., Dellagostin, Odir A.

“…Mycoplasma hyopneumoniae, the etiological agent of swine enzootic pneumonia, is an important pathogen in the swine industry worldwide. Vaccination is the most…”
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Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: importance to cell metabolism, function, and dysfunction Autor Newsholme, Philip, Keane, Kevin N, Carlessi, Rodrigo, Cruzat, Vinicius

“…It is now accepted that nutrient abundance in the blood, especially glucose, leads to the generation of reactive oxygen species (ROS), ultimately leading to…”
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Mechanisms of vitamin D action in skeletal muscle Autor Montenegro, Karina Romeu, Cruzat, Vinicius, Carlessi, Rodrigo, Newsholme, Philip

“…Vitamin D receptor expression and associated function have been reported in various muscle models, including C 2 C 12 , L6 cell lines and primary human…”
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Lupin seed hydrolysate promotes G-protein-coupled receptor, intracellular Ca2+ and enhanced glycolytic metabolism-mediated insulin secretion from BRIN-BD11 pancreatic beta cells Autor Tapadia, Mrunmai, Carlessi, Rodrigo, Johnson, Stuart, Utikar, Ranjeet, Newsholme, Philip

“…Lupin seed proteins have been reported to exhibit hypoglycaemic effects in animals and humans following oral administration, however little is known about its…”
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Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds Autor Tapadia, Mrunmai, Johnson, Stuart, Utikar, Ranjeet, Newsholme, Philip, Carlessi, Rodrigo

“…[Display omitted] •Proteolytically digested γ-conglutin from lupin possesses anti-diabetic properties.•γ-conglutin peptides promote glucose uptake and glycogen…”
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Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction Autor Homem de Bittencourt, Paulo Ivo, Carlessi, Rodrigo, Cruzat, Vinicius Fernandes, Keane, Kevin N., Newsholme, Philip

“…The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress…”
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Preclinical pharmacokinetics, pharmacodynamics, and toxicity of novel small-molecule GPR119 agonists to treat type-2 diabetes and obesity Autor Patil, Mohan, Casari, Ilaria, Thapa, Dinesh, Warne, Leon N., Dallerba, Elena, Massi, Massimiliano, Carlessi, Rodrigo, Falasca, Marco

“…The escalating global prevalence of type-2 diabetes (T2D) and obesity necessitates the development of novel oral medications. Agonism at G-protein coupled…”
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Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells Autor Rowlands, Jordan, Cruzat, Vinicius, Carlessi, Rodrigo, Newsholme, Philip

“…•Chronic GLP-1R stimulation promotes β-cell metabolic reprogramming.•IGF-1R and IR are important for β-cell development, function and proliferation.•GLP-1…”
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Chronic metabolic effects of novel gut-oriented small-molecule GPR119 agonists in diet-induced obese mice Autor Patil, Mohan, Thapa, Dinesh, Warne, Leon N., Lareu, Ricky R., Dallerba, Elena, Lian, Jerome, Massi, Massimiliano, Carlessi, Rodrigo, Falasca, Marco

“…The pharmacological activation of G-protein coupled receptor-119 (GPR119) modulates glucose, energy, and hepatic lipid homeostasis in type-2 diabetes (T2D). We…”
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Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity Autor Carlessi, Rodrigo, Rowlands, Jordan, Ellison, Gaewyn, Helena de Oliveira Alves, Heloisa, Newsholme, Philip, Mamotte, Cyril

“…Studies have reported that plasma glutamine is reduced in type 2 diabetes (T2D) patients. Glutamine supplementation improves glycaemic control, however the…”
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