Výsledky vyhľadávania - "Cardiovascular Diseases - genetics"

Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study Autor Lv, Yuebin, Zhang, Yue, Li, Xinwei, Gao, Xiang, Ren, Yongyong, Deng, Luojia, Xu, Lanjing, Zhou, Jinhui, Wu, Bing, Wei, Yuan, Cui, Xingyao, Xu, Zinan, Guo, Yanbo, Qiu, Yidan, Ye, Lihong, Chen, Chen, Wang, Jun, Li, Chenfeng, Luo, Yufei, Yin, Zhaoxue, Mao, Chen, Yu, Qiong, Lu, Hui, Kraus, Virginia Byers, Zeng, Yi, Tong, Shilu, Shi, Xiaoming

“…Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an…”
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Mendelian Randomization as an Approach to Assess Causality Using Observational Data Autor Sekula, Peggy, Del Greco M, Fabiola, Pattaro, Cristian, Köttgen, Anna

“…: the alleles of this exposure-associated genetic variant are randomly allocated and not subject to reverse causation…”
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Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels Autor Dehghan, Abbas, Dupuis, Josée, Barbalic, Maja, Bis, Joshua C, Eiriksdottir, Gudny, Lu, Chen, Pellikka, Niina, Wallaschofski, Henri, Kettunen, Johannes, Henneman, Peter, Baumert, Jens, Strachan, David P, Fuchsberger, Christian, Vitart, Veronique, Wilson, James F, Paré, Guillaume, Naitza, Silvia, Rudock, Megan E, Surakka, Ida, de Geus, Eco J C, Alizadeh, Behrooz Z, Guralnik, Jack, Shuldiner, Alan, Tanaka, Toshiko, Zee, Robert Y L, Schnabel, Renate B, Nambi, Vijay, Kavousi, Maryam, Ripatti, Samuli, Nauck, Matthias, Smith, Nicholas L, Smith, Albert V, Sundvall, Jouko, Scheet, Paul, Liu, Yongmei, Ruokonen, Aimo, Rose, Lynda M, Larson, Martin G, Hoogeveen, Ron C, Freimer, Nelson B, Teumer, Alexander, Tracy, Russell P, Launer, Lenore J, Buring, Julie E, Yamamoto, Jennifer F, Folsom, Aaron R, Sijbrands, Eric J G, Pankow, James, Elliott, Paul, Keaney, John F, Sun, Wei, Sarin, Antti-Pekka, Fontes, João D, Badola, Sunita, Astor, Brad C, Hofman, Albert, Pouta, Anneli, Werdan, Karl, Greiser, Karin H, Kuss, Oliver, Meyer zu Schwabedissen, Henriette E, Thiery, Joachim, Jamshidi, Yalda, Nolte, Ilja M, Soranzo, Nicole, Spector, Timothy D, Völzke, Henry, Parker, Alexander N, Aspelund, Thor, Bates, David, Young, Lauren, Tsui, Kim, Siscovick, David S, Guo, Xiuqing, Rotter, Jerome I, Uda, Manuela, Schlessinger, David, Rudan, Igor, Hicks, Andrew A, Penninx, Brenda W, Thorand, Barbara, Gieger, Christian, Coresh, Joe, Willemsen, Gonneke, Harris, Tamara B, Uitterlinden, Andre G, Järvelin, Marjo-Riitta, Rice, Kenneth, Radke, Dörte, Salomaa, Veikko, Willems van Dijk, Ko, Boerwinkle, Eric, Vasan, Ramachandran S, Ferrucci, Luigi, Gibson, Quince D, Bandinelli, Stefania, Snieder, Harold, Boomsma, Dorret I, Xiao, Xiangjun, Campbell, Harry

“…C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic…”
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A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors Autor Nemet, Ina, Saha, Prasenjit Prasad, Gupta, Nilaksh, Zhu, Weifei, Romano, Kymberleigh A, Skye, Sarah M, Cajka, Tomas, Mohan, Maradumane L, Li, Lin, Wu, Yuping, Funabashi, Masanori, Ramer-Tait, Amanda E, Naga Prasad, Sathyamangla Venkata, Fiehn, Oliver, Rey, Federico E, Tang, W H Wilson, Fischbach, Michael A, DiDonato, Joseph A, Hazen, Stanley L

“…Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine…”
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Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution Autor Chen, Rui, Hu, Bin, Liu, Ying, Xu, Jianxun, Yang, Guosheng, Xu, Diandou, Chen, Chunying

“…Air pollution constitutes the major threat to human health, whereas their adverse impacts and underlying mechanisms of different particular matters are not…”
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Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images Autor Zhao, Bingxin, Li, Tengfei, Fan, Zirui, Yang, Yue, Shu, Juan, Yang, Xiaochen, Wang, Xifeng, Luo, Tianyou, Tang, Jiarui, Xiong, Di, Wu, Zhenyi, Li, Bingxuan, Chen, Jie, Shan, Yue, Tomlinson, Chalmer, Zhu, Ziliang, Li, Yun, Stein, Jason L, Zhu, Hongtu

“… We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects…”
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Benefits of the Mediterranean Diet: Insights From the PREDIMED Study Autor Martínez-González, Miguel A., Salas-Salvadó, Jordi, Estruch, Ramón, Corella, Dolores, Fitó, Montse, Ros, Emilio

“…The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet…”
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The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids Autor Fu, Jingyuan, Bonder, Marc Jan, Cenit, María Carmen, Tigchelaar, Ettje F, Maatman, Astrid, Dekens, Jackie A M, Brandsma, Eelke, Marczynska, Joanna, Imhann, Floris, Weersma, Rinse K, Franke, Lude, Poon, Tiffany W, Xavier, Ramnik J, Gevers, Dirk, Hofker, Marten H, Wijmenga, Cisca, Zhernakova, Alexandra

“… We studied 893 subjects from the Life-Lines-DEEP population cohort. After correcting for age and sex, we identified…”
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Impact of periodontitis on gingival crevicular fluid miRNAs profiles associated with cardiovascular disease risk Autor Isola, Gaetano, Santonocito, Simona, Distefano, Alfio, Polizzi, Alessandro, Vaccaro, Manuel, Raciti, Giuseppina, Alibrandi, Angela, Li Volti, Giovanni

“… Materials and Methods For the present study, healthy controls (n = 28) and subjects with CVD (n = 28), periodontitis (n = 30) and periodontitis + CVD (n = 29) were enrolled…”
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Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury Autor Viereck, Janika, Thum, Thomas

“…vascular pathophysiology. In addition, ncRNAs are released into the circulation where they are present in concentration levels that differ between healthy subjects and diseased patients…”
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A polygenic risk score predicts atrial fibrillation in cardiovascular disease Autor Marston, Nicholas A, Garfinkel, Amanda C, Kamanu, Frederick K, Melloni, Giorgio M, Roselli, Carolina, Jarolim, Petr, Berg, David D, Bhatt, Deepak L, Bonaca, Marc P, Cannon, Christopher P, Giugliano, Robert P, O'Donoghue, Michelle L, Raz, Itamar, Scirica, Benjamin M, Braunwald, Eugene, Morrow, David A, Ellinor, Patrick T, Lubitz, Steven A, Sabatine, Marc S, Ruff, Christian T

“… A total of 36,662 subjects without prior AF were analyzed from four TIMI trials. Subjects were divided into quintiles using a validated polygenic risk score (PRS) for AF…”
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Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y Autor García-Calzón, Sonia, Zalba, Guillermo, Ruiz-Canela, Miguel, Shivappa, Nitin, Hébert, James R, Martínez, J Alfredo, Fitó, Montserrat, Gómez-Gracia, Enrique, Martínez-González, Miguel A, Marti, Amelia

“…Dietary factors can affect telomere length (TL), a biomarker of aging, through oxidation and inflammation-related mechanisms. A Dietary Inflammatory Index…”
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Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review Autor Eberle, Claudia, Kirchner, Michaela F., Herden, Raphaela, Stichling, Stefanie

“…There is lots of evidence that maternal peri-gestational metabolic, genomic and environmental conditions are closely linked to metabolic and cardiovascular…”
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Genome-wide association study of medication-use and associated disease in the UK Biobank Autor Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M., Wray, Naomi R.

“…Genome-wide association studies (GWASs) of medication use may contribute to understanding of disease etiology, could generate new leads relevant for drug…”
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Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity Autor Sookoian, Silvia, Castaño, Gustavo O., Scian, Romina, Mallardi, Pablo, Fernández Gianotti, Tomas, Burgueño, Adriana L., San Martino, Julio, Pirola, Carlos J.

“… A total of 361 individuals (135 control subjects and 226 patients with histologically proven NAFLD…”
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Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention Autor Masoudkabir, Farzad, Sarrafzadegan, Nizal, Gotay, Carolyn, Ignaszewski, Andrew, Krahn, Andrew D., Davis, Margot K., Franco, Christopher, Mani, Arya

“…Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity worldwide. Strategies to improve their treatment and prevention are…”
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Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease Autor Sabater-Lleal, Maria, Huang, Jie, Chasman, Daniel, Naitza, Silvia, Dehghan, Abbas, Johnson, Andrew D, Teumer, Alexander, Reiner, Alex P, Folkersen, Lasse, Basu, Saonli, Rudnicka, Alicja R, Trompet, Stella, Mälarstig, Anders, Baumert, Jens, Bis, Joshua C, Guo, Xiuqing, Hottenga, Jouke J, Shin, So-Youn, Lopez, Lorna M, Lahti, Jari, Tanaka, Toshiko, Yanek, Lisa R, Oudot-Mellakh, Tiphaine, Wilson, James F, Navarro, Pau, Huffman, Jennifer E, Zemunik, Tatijana, Redline, Susan, Mehra, Reena, Pulanic, Drazen, Rudan, Igor, Wright, Alan F, Kolcic, Ivana, Polasek, Ozren, Wild, Sarah H, Campbell, Harry, Curb, J David, Wallace, Robert, Liu, Simin, Eaton, Charles B, Becker, Diane M, Becker, Lewis C, Bandinelli, Stefania, Räikkönen, Katri, Widen, Elisabeth, Palotie, Aarno, Fornage, Myriam, Green, David, Gross, Myron, Davies, Gail, Harris, Sarah E, Liewald, David C, Starr, John M, Williams, Frances M K, Grant, Peter J, Spector, Timothy D, Strawbridge, Rona J, Silveira, Angela, Sennblad, Bengt, Rivadeneira, Fernando, Uitterlinden, Andre G, Franco, Oscar H, Hofman, Albert, van Dongen, Jenny, Willemsen, Gonneke, Boomsma, Dorret I, Yao, Jie, Swords Jenny, Nancy, Haritunians, Talin, McKnight, Barbara, Lumley, Thomas, Taylor, Kent D, Rotter, Jerome I, Psaty, Bruce M, Peters, Annette, Gieger, Christian, Illig, Thomas, Grotevendt, Anne, Homuth, Georg, Völzke, Henry, Kocher, Thomas, Goel, Anuj, Franzosi, Maria Grazia, Seedorf, Udo, Clarke, Robert, Steri, Maristella, Tarasov, Kirill V, Sanna, Serena, Schlessinger, David, Stott, David J, Sattar, Naveed, Buckley, Brendan M, Rumley, Ann, Lowe, Gordon D, McArdle, Wendy L, Chen, Ming-Huei, Tofler, Geoffrey H, Song, Jaejoon, Boerwinkle, Eric, Folsom, Aaron R

“… We conducted a meta-analysis of 28 genome-wide association studies including >90 000 subjects of European ancestry, the first genome-wide association meta-analysis…”
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Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421 Autor Lambert, Daniel W, Lambert, Louise A, Clarke, Nicola E, Hooper, Nigel M, Porter, Karen E, Turner, Anthony J

“…ACE2 (angiotensin converting enzyme 2) plays a critical role in the local tissue RAS (renin-angiotensin system) by hydrolysing the potent hypertensive and…”
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The dual and opposite role of the TM6SF2‐rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta‐analysis Autor Pirola, Carlos J., Sookoian, Silvia

“…), compared with subjects homozygous for the ancestral C allele (EE genotype), are protected…”
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Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Autor Lubos, Edith, Loscalzo, Joseph, Handy, Diane E

“…Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all cells by mitochondrial and enzymatic sources. Left unchecked, these…”
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