Výsledky vyhľadávania - "Capozza, Franco"

Role of cholesterol in the development and progression of breast cancer Autor Llaverias, Gemma, Danilo, Christiane, Mercier, Isabelle, Daumer, Kristin, Capozza, Franco, Williams, Terence M, Sotgia, Federica, Lisanti, Michael P, Frank, Philippe G

“…Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the…”
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Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment Autor Martinez-Outschoorn, Ubaldo E., Trimmer, Casey, Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Zhou, Jie, Wang, Chenguang, Pavlides, Stephanos, Martinez-Cantarin, Maria P., Capozza, Franco, Witkiewicz, Agnieszka K., Flomenberg, Neal, Howell, Anthony, Pestell, Richard G., Caro, Jaime, Lisanti, Michael P., Sotgia, Federica

“…Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells induce oxidative stress in adjacent cancer-associated fibroblasts,…”
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The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts Autor Bonuccelli, Gloria, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Pavlides, Stephanos, Pestell, Richard G., Fatatis, Alessandro, Witkiewicz, Agnieszka K., Vander Heiden, Matthew G., Migneco, Gemma, Chiavarina, Barbara, Frank, Philippe G., Capozza, Franco, Flomenberg, Neal, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“…We and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) as a powerful single independent…”
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Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts Autor Trimmer, Casey, Sotgia, Federica, Whitaker-Menezes, Diana, Balliet, Renee M., Eaton, Gregory, Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Howell, Anthony, Iozzo, Renato V., Pestell, Richard G., Scherer, Philipp E., Capozza, Franco, Lisanti, Michael P.

“…We have recently proposed a new model for understanding tumor metabolism, termed: "The Autophagic Tumor Stroma Model of Cancer Metabolism". In this new…”
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CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway Autor Trimmer, Casey, Whitaker-Menezes, Diana, Bonuccelli, Gloria, Milliman, Janet N, Daumer, Kristin M, Aplin, Andrew E, Pestell, Richard G, Sotgia, Federica, Lisanti, Michael P, Capozza, Franco

“…Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal…”
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The milk protein α-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis Autor Bonuccelli, Gloria, Castello-Cros, Remedios, Capozza, Franco, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Tsirigos, Aristotelis, Xuanmao, Jiao, Whitaker-Menezes, Diana, Howell, Anthony, Lisanti, Michael P., Sotgia, Federica

“…Here, we identified the milk protein α-casein as a novel suppressor of tumor growth and metastasis. Briefly, Met-1 mammary tumor cells expressing α-casein…”
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Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis Autor Castello-Cros, Remedios, Bonnuccelli, Gloria, Molchansky, Alex, Capozza, Franco, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pestell, Richard G., Whitaker-Menezes, Diana, Sotgia, Federica, Lisanti, Michael P

“…We have previously demonstrated that loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts is a strong and independent predictor of poor clinical…”
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Localized Treatment with a Novel FDA-Approved Proteasome Inhibitor Blocks the Degradation of Dystrophin and Dystrophin-Associated Proteins in mdx Mice Autor Bonuccelli, Gloria, Sotgia, Federica, Capozza, Franco, Gazzerro, Elisabetta, Minetti, Carlo, Lisanti, Michael P.

“…Duchenne Muscular Dystrophy (DMD) is an incurable inherited disease ofchildhood, characterized by progressive muscle degeneration and weakness. Our…”
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Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation Autor Capozza, Franco, Williams, Terence M, Schubert, William, McClain, Steve, Bouzahzah, Boumediene, Sotgia, Federica, Lisanti, Michael P

“…Caveolin-1 is the principal protein component of caveolae membrane domains, which are located at the cell surface in most cell types. Evidence has accumulated…”
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Regulation of insulin receptor substrate-1 expression levels by caveolin-1 Autor Chen, Jia, Capozza, Franco, Wu, An, deAngelis, Tiziana, Sun, Hongzhi, Lisanti, Michael, Baserga, Renato

“…The insulin receptor substrate‐1 (IRS‐1), a docking protein of the type 1 insulin‐like growth factor receptor (IGF‐IR) plays a significant role in cell…”
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Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells Autor Capozza, Franco, Cohen, Alex W, Cheung, Michelle W-C, Sotgia, Federica, Schubert, William, Battista, Michela, Lee, Hyangkyu, Frank, Philippe G, Lisanti, Michael P

“…It is generally well accepted that caveolin-3 expression is muscle specific, whereas caveolin-1 and -2 are coexpressed in a variety of cell types, including…”
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Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression Autor Di Vizio, Dolores, Sotgia, Federica, Williams, Terence M., Hassan, Ghada S., Capozza, Franco, Frank, Philippe G., Pestell, Richard G., Loda, Massimo, Freeman, Michael R., Lisanti, Michael P.

“…Prostate cancer is the second leading cause of cancer-related deaths in men. Fatty acid synthase (FASN) is normally upregulated during human prostate cancer…”
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Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells Autor Sotgia, Federica, Razani, Babak, Bonuccelli, Gloria, Schubert, William, Battista, Michela, Lee, Hyangkyu, Capozza, Franco, Schubert, Ann Lane, Minetti, Carlo, Buckley, J Thomas, Lisanti, Michael P

“…The relationship between glycosylphosphatidyl inositol (GPI)-linked proteins and caveolins remains controversial. Here, we derived fibroblasts from Cav-1 null…”
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Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation Autor Trimmer, Casey, Bonuccelli, Gloria, Katiyar, Sanjay, Sotgia, Federica, Pestell, Richard G, Lisanti, Michael P, Capozza, Franco

“…Caveolin-1 (Cav1) is a scaffolding protein that serves to regulate the activity of several signaling molecules. Its loss has been implicated in the…”
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Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration Autor Capozza, Franco, Trimmer, Casey, Castello-Cros, Remedios, Katiyar, Sanjay, Whitaker-Menezes, Diana, Follenzi, Antonia, Crosariol, Marco, Llaverias, Gemma, Sotgia, Federica, Pestell, Richard G, Lisanti, Michael P

“…Both cell-autonomous and non-cell-autonomous factors contribute to tumor growth and metastasis of melanoma. The function of caveolin-1 (Cav1), a…”
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Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation Autor Schubert, William, Sotgia, Federica, Cohen, Alex W, Capozza, Franco, Bonuccelli, Gloria, Bruno, Claudio, Minetti, Carlo, Bonilla, Eduardo, Dimauro, Salvatore, Lisanti, Michael P

“…Here, we examine the role of "non-muscle" caveolins (Cav-1 and Cav-2) in skeletal muscle biology. Our results indicate that skeletal muscle fibers from male…”
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Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature Autor Bonuccelli, Gloria, Casimiro, Mathew C, Sotgia, Federica, Wang, Chenguang, Liu, Manran, Katiyar, Sanjay, Zhou, Jie, Dew, Elliott, Capozza, Franco, Daumer, Kristin M, Minetti, Carlo, Milliman, Janet N, Alpy, Fabien, Rio, Marie-Christine, Tomasetto, Catherine, Mercier, Isabelle, Flomenberg, Neal, Frank, Philippe G, Pestell, Richard G, Lisanti, Michael P

“…Here we used the Met-1 cell line in an orthotopic transplantation model in FVB/N mice to dissect the role of the Cav-1(P132L) mutation in human breast cancer…”
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Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells Autor Williams, Terence M, Sotgia, Federica, Lee, Hyangkyu, Hassan, Ghada, Di Vizio, Dolores, Bonuccelli, Gloria, Capozza, Franco, Mercier, Isabelle, Rui, Hallgeir, Pestell, Richard G, Lisanti, Michael P

“…Here, we investigate the role of caveolin-1 (Cav-1) in breast cancer onset and progression, with a focus on epithelial-stromal interactions, ie, the tumor…”
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Cav1 inhibits benign skin tumor development in a two-stage carcinogenesis model by suppressing epidermal proliferation Autor Trimmer, Casey, Sotgia, Federica, Lisanti, Michael P, Capozza, Franco

“…Caveolin-1 (Cav1) is the main protein component of the membrane lipid rafts caveolae. Cav1 serves as a scaffolding protein that compartmentalizes a multitude…”
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Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle Autor Capozza, Franco, Combs, Terry P, Cohen, Alex W, Cho, You-Ree, Park, So-Young, Schubert, William, Williams, Terence M, Brasaemle, Dawn L, Jelicks, Linda A, Scherer, Philipp E, Kim, Jason K, Lisanti, Michael P

“…Caveolin-3 (Cav-3) is expressed predominantly in skeletal muscle fibers, where it drives caveolae formation at the muscle cell's plasma membrane. In vitro…”
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