Suchergebnisse - "Cancro, Michael P"

Age-Associated B Cells von Cancro, Michael P

“… The age-associated B cell subset has been the focus of increasing interest over the last decade. These cells have a unique cell surface phenotype and …”
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Memory B cells and plasma cells: The differentiative continuum of humoral immunity von Cancro, Michael P., Tomayko, Mary M.

“… Summary Immunological memory is a composite of lasting antibody titers maintained by plasma cells in conjunction with memory T and B cells. Memory B cells are …”
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Age-associated B cells: key mediators of both protective and autoreactive humoral responses von Naradikian, Martin S., Hao, Yi, Cancro, Michael P.

“… A subset of B cells with unique phenotypic and functional features—termed Age‐associated B cells (ABCs)—has recently been identified in both mice and humans …”
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A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice von Hao, Yi, O'Neill, Patrick, Naradikian, Martin S, Scholz, Jean L, Cancro, Michael P

“… We have discovered a distinct mature B-cell subset that accumulates with age, which we have termed age-associated B cells. These cells comprise up to 30% of …”
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Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation von Sharma, Shruti, Fitzgerald, Katharine A, Cancro, Michael P, Marshak-Rothstein, Ann

“… Distinct families of germline-encoded pattern recognition receptors can sense both microbial and endogenous nucleic acids. These DNA and RNA sensors include …”
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Role of type I interferons in the activation of autoreactive B cells von Kiefer, Kerstin, Oropallo, Michael A, Cancro, Michael P, Marshak‐Rothstein, Ann

“… Type I interferons (IFNs) are a family of cytokines involved in the defense against viral infections that play a key role in the activation of both the innate …”
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The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus von Cancro, Michael P., D’Cruz, David P., Khamashta, Munther A.

“… SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B …”
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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells von Berry, Corbett T., Liu, Xiaohong, Myles, Arpita, Nandi, Satabdi, Chen, Youhai H., Hershberg, Uri, Brodsky, Igor E., Cancro, Michael P., Lengner, Christopher J., May, Michael J., Freedman, Bruce D.

“… B cell receptor (BCR) engagement induces naive B cells to differentiate and perform critical immune-regulatory functions. Acquisition of functional specificity …”
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The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis von Abe, Toshiharu, AlSarhan, Mohammed, Benakanakere, Manjunatha R, Maekawa, Tomoki, Kinane, Denis F, Cancro, Michael P, Korostoff, Jonathan M, Hajishengallis, George

“… B-lineage cells (B lymphocytes and plasma cells) predominate in the inflammatory infiltrate of human chronic periodontitis. However, their role in disease …”
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Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes von Awasthi, Sita, Hook, Lauren M, Pardi, Norbert, Wang, Fushan, Myles, Arpita, Cancro, Michael P, Cohen, Gary H, Weissman, Drew, Friedman, Harvey M

“… The goals of a genital herpes vaccine are to prevent painful genital lesions and reduce or eliminate subclinical infection that risks transmission to partners …”
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A comparative review of aging and B cell function in mice and humans von Scholz, Jean L, Diaz, Alain, Riley, Richard L, Cancro, Michael P, Frasca, Daniela

“… •B cell generation in bone marrow declines with age in mice but may be maintained in humans.•Shifts in naïve and antigen-experienced peripheral B cell subsets …”
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BAFF receptors and ligands create independent homeostatic niches for B cell subsets von Naradikian, Martin S, Perate, Alison R, Cancro, Michael P

“… •Systemic versus locally produced BAFF mediate distinct functions in homeostasis and selection.•Differential expression of BAFF receptors defines independent …”
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T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow von Glatman Zaretsky, Arielle, Konradt, Christoph, Dépis, Fabien, Wing, James B., Goenka, Radhika, Atria, Daniela Gomez, Silver, Jonathan S., Cho, Sunglim, Wolf, Amaya I., Quinn, William J., Engiles, Julie B., Brown, Dorothy C., Beiting, Daniel, Erikson, Jan, Allman, David, Cancro, Michael P., Sakaguchi, Shimon, Lu, Li-Fan, Benoist, Christophe O., Hunter, Christopher A.

“… Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies after infection or vaccination, but questions remain about the …”
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Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses von Nündel, Kerstin, Green, Nathaniel M, Shaffer, Arthur L, Moody, Krishna L, Busto, Patricia, Eilat, Dan, Miyake, Kensuke, Oropallo, Michael A, Cancro, Michael P, Marshak-Rothstein, Ann

“… Endosomal TLRs play an important role in systemic autoimmune diseases, such as systemic erythematosus lupus, in which DNA- and RNA-associated autoantigens …”
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New roles for the BLyS/BAFF family in antigen-experienced B cell niches von Goenka, Radhika, Scholz, Jean L., Sindhava, Vishal J., Cancro, Michael P.

“… BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in …”
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B cells and aging: a historical perspective von Cancro, Michael P

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Asymmetric B cell division in the germinal center reaction von Barnett, Burton E, Ciocca, Maria L, Goenka, Radhika, Barnett, Lisa G, Wu, Junmin, Laufer, Terri M, Burkhardt, Janis K, Cancro, Michael P, Reiner, Steven L

“… Lifelong antibody responses to vaccination require reorganization of lymphoid tissue and dynamic intercellular communication called the germinal center …”
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A role for IL-27p28 as an antagonist of gp130-mediated signaling von Stumhofer, Jason S, Tait, Elia D, III, William J Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri A, O'Hara, Aisling C, Chen, Yi, Jones, Michael L, Saris, Christiaan J M, Rose-John, Stefan, Cua, Daniel J, Jones, Simon A, Elloso, M Merle, Grötzinger, Joachim, Cancro, Michael P, Levin, Steven D, Hunter, Christopher A

“… The heterodimeric cytokine IL-27 consists of the subunits p28 and EBI3. Hunter and colleagues demonstrate that p28 acting alone can inhibit the signaling of …”
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Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation von Higdon, Lauren E, Cancro, Michael P

“… Antibody affinity maturation involves selective survival of high affinity B cells and is thought to require the germinal center (GC) microenvironment. In this …”
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Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors von Jacob, Chaim O., Yu, Ning, Sindhava, Vishal, Cancro, Michael P., Pawar, Rahul D., Putterman, Chaim, Stohl, William

“… Objective To determine the development of systemic lupus erythematosus (SLE) in NZM 2328 (NZM) mice deficient in 2 BAFF receptors. Methods NZM.BR‐3–/–.BCMA–/–, …”
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