Suchergebnisse - "Cancer chemotherapy and pharmacology"

Advances in ovarian cancer therapy von Cortez, Alexander J., Tudrej, Patrycja, Kujawa, Katarzyna A., Lisowska, Katarzyna M.

“… Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of …”
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Tumor microenvironment promotes breast cancer chemoresistance von Mehraj, Umar, Dar, Abid Hamid, Wani, Nissar A., Mir, Manzoor A.

“… Breast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis …”
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Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells von Nicoletto, Rachel E., Ofner, Clyde M.

“… Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety of tumor types, such as breast cancer. Despite the long history of …”
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Disulfiram: a novel repurposed drug for cancer therapy von Lu, Chen, Li, Xinyan, Ren, Yongya, Zhang, Xiao

“… Cancer is a major health issue worldwide and the global burden of cancer is expected to reduce the costs of treatment as well as prolong the survival time. One …”
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The role of thioredoxin system in cancer: strategy for cancer therapy von Jia, Jin-Jing, Geng, Wen-Shuo, Wang, Zhan-Qi, Chen, Lei, Zeng, Xian-Si

“… Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well …”
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Involvement of cytochrome P450 enzymes in inflammation and cancer: a review von Stipp, Maria Carolina, Acco, Alexandra

“… Cytochrome P450 (CYP) enzymes are responsible for the biotransformation of drugs, xenobiotics, and endogenous substances. This enzymatic activity can be …”
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Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review von Madsen, Marie Lindhard, Due, Hanne, Ejskjær, Niels, Jensen, Paw, Madsen, Jakob, Dybkær, Karen

“… Purpose Vincristine is widely used as anticancer therapy for a variety of hematological malignancies. The treatment is limited by progressive …”
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A panel of serum exosomal microRNAs as predictive markers for chemoresistance in advanced colorectal cancer von Jin, Guoying, Liu, Yuhang, Zhang, Jia, Bian, Zehua, Yao, Surui, Fei, Bojian, Zhou, Leyuan, Yin, Yuan, Huang, Zhaohui

“… Background Chemoresistance is a common problem for cancer treatment worldwide. Circulating exosomal microRNAs (miRNAs) have been considered as promising …”
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Randomized, prospective, comparative study on the effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis von Choi, Jong Hwan, Chung, Woo Jin, Bae, Si Hyun, Song, Do Seon, Song, Myeong Jun, Kim, Young Seok, Yim, Hyung Joon, Jung, Young Kul, Suh, Sang Jun, Park, Jun Yong, Kim, Do Young, Kim, Seung Up, Cho, Sung Bum

“… Background/aims Treatment responses of advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remain unacceptably low and treatment …”
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A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer von Greil, Richard, Greil-Ressler, Sigrun, Weiss, Lukas, Schönlieb, Charlotte, Magnes, Teresa, Radl, Bianca, Bolger, Gordon T., Vcelar, Brigitta, Sordillo, Peter P.

“… Purpose This study was conducted to investigate the safety and tolerability of increasing doses of liposomal curcumin in patients with metastatic cancer …”
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The thioredoxin system and cancer therapy: a review von Mohammadi, Fariba, Soltani, Arash, Ghahremanloo, Atefeh, Javid, Hossein, Hashemy, Seyed Isaac

“… Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. In …”
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Genistein combined with FOLFOX or FOLFOX–Bevacizumab for the treatment of metastatic colorectal cancer: phase I/II pilot study von Pintova, Sofya, Dharmupari, Sirish, Moshier, Erin, Zubizarreta, Nicole, Ang, Celina, Holcombe, Randall F.

“… Background Epidemiologic and preclinical data suggest isoflavones have anticancer activity in colorectal malignancy prevention and treatment. This is the first …”
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A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors von Raez, Luis E., Papadopoulos, Kyriakos, Ricart, Alejandro D., Chiorean, E. Gabriella, DiPaola, Robert S., Stein, Mark N., Rocha Lima, Caio M., Schlesselman, James J., Tolba, Khaled, Langmuir, Virginia K., Kroll, Stewart, Jung, Donald T., Kurtoglu, Metin, Rosenblatt, Joseph, Lampidis, Theodore J.

“… Purpose This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy- d …”
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A phase II study of modified FOLFIRINOX for chemotherapy-naïve patients with metastatic pancreatic cancer von Ozaka, Masato, Ishii, Hiroshi, Sato, Tosiya, Ueno, Makoto, Ikeda, Masafumi, Uesugi, Kazuhiro, Sata, Naohiro, Miyashita, Kouichirou, Mizuno, Nobumasa, Tsuji, Kunihiro, Okusaka, Takuji, Furuse, Junji

“… Background We evaluated the efficacy and safety of a modified FOLFIRINOX regimen for chemotherapy-naïve patients with metastatic pancreatic cancer. Methods …”
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Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis von Abdel-Daim, Mohamed M., kilany, Omnia E., Khalifa, Hesham A., Ahmed, Amal A. M.

“… Purpose Doxorubicin (DOX) is a highly active antineoplastic agent; however, its clinical use is limited due to associated cardiotoxicity. This study was …”
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Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine von Silverman, Jeffrey A., Deitcher, Steven R.

“… Vincristine (VCR) is a mainstay of treatment of hematologic malignancies and solid tumors due to its well-defined mechanism of action, demonstrated anticancer …”
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Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance von Chan, Wai-Jo Jocelin, Adiwidjaja, Jeffry, McLachlan, Andrew J., Boddy, Alan V., Harnett, Joanna E.

“… Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by people …”
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Positioning of proteasome inhibitors in therapy of solid malignancies von Roeten, Margot S. F., Cloos, Jacqueline, Jansen, Gerrit

“… Targeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system, has emerged as an attractive novel cancer chemotherapeutic …”
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Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway von Burris, Howard A.

“… Background Most targeted anticancer therapies, as well as cytotoxic and radiation therapies, are encumbered by the development of secondary resistance by …”
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Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting von Morrissey, Kari M., Marchand, Mathilde, Patel, Hina, Zhang, Rong, Wu, Benjamin, Phyllis Chan, H., Mecke, Almut, Girish, Sandhya, Jin, Jin Y., Winter, Helen R., Bruno, René

“… Purpose To determine the exposure–response (ER) relationships between atezolizumab exposure and efficacy or safety in patients with advanced non-small cell …”
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