Výsledky vyhľadávania - "Callan, Curtis G"

Maximum entropy models for antibody diversity Autor Mora, Thierry, Walczak, Aleksandra M, Bialek, William, Callan, Jr, Curtis G

“…Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building…”
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Quantifying selection in immune receptor repertoires Autor Elhanati, Yuval, Murugan, Anand, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“…The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell…”
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Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay Autor Melnikov, Alexandre, Murugan, Anand, Zhang, Xiaolan, Tesileanu, Tiberiu, Wang, Li, Rogov, Peter, Feizi, Soheil, Gnirke, Andreas, Callan, Curtis G, Kinney, Justin B, Kellis, Manolis, Lander, Eric S, Mikkelsen, Tarjei S

“…An improved understanding of enhancers in mammalian genomes could facilitate the design of new regulatory elements. Melnikov et al . synthesize thousands of…”
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Information flow and optimization in transcriptional regulation Autor Tkacik, Gasper, Callan, Jr, Curtis G, Bialek, William

“…In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor…”
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Statistical inference of the generation probability of T-cell receptors from sequence repertoires Autor Murugan, Anand, Mora, Thierry, Walczak, Aleksandra M, Callan, Jr, Curtis G

“…Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding sequence for certain cell surface receptors is at the origin of immune…”
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Inferring processes underlying B-cell repertoire diversity Autor Elhanati, Yuval, Sethna, Zachary, Marcou, Quentin, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“…We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence…”
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Measures of epitope binding degeneracy from T cell receptor repertoires Autor Mayer, Andreas, Callan, Jr, Curtis G

“…Adaptive immunity is driven by specific binding of hypervariable receptors to diverse molecular targets. The sequence diversity of receptors and targets are…”
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Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence Autor Kinney, Justin B, Murugan, Anand, Callan, Jr, Curtis G, Cox, Edward C

“…Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the…”
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Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination Autor Elhanati, Yuval, Sethna, Zachary, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.

“…Summary Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR) sequences are found in a large number of individual mice and…”
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Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites Autor Mustonen, Ville, Kinney, Justin, Callan, Jr, Curtis G, Lässig, Michael

“…We present a genomewide cross-species analysis of regulation for broad-acting transcription factors in yeast. Our model for binding site evolution is founded…”
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Insights into immune system development and function from mouse T-cell repertoires Autor Sethna, Zachary, Elhanati, Yuval, Dudgeon, Crissy S, Callan, Jr, Curtis G, Levine, Arnold J, Mora, Thierry, Walczak, Aleksandra M

“…The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors. This diversity…”
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Maximum entropy models for patterns of gene expression Autor Sarra, Camilla, Sarra, Leopoldo, Di Carlo, Luca, GrandPre, Trevor, Zhang, Yaojun, Callan, Curtis G, Bialek, William

“…New experimental methods make it possible to measure the expression levels of many genes, simultaneously, in snapshots from thousands or even millions of…”
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OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs Autor Sethna, Zachary, Elhanati, Yuval, Callan, Curtis G, Walczak, Aleksandra M, Mora, Thierry

“…High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination…”
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Precise physical models of protein-DNA interaction from high-throughput data Autor Kinney, Justin B, Tkacik, Gasper, Callan, Jr, Curtis G

“…A cell's ability to regulate gene transcription depends in large part on the energy with which transcription factors (TFs) bind their DNA regulatory sites…”
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Evaluation of methods for modeling transcription factor sequence specificity Autor Weirauch, Matthew T, Cote, Atina, Norel, Raquel, Annala, Matti, Zhao, Yue, Riley, Todd R, Saez-Rodriguez, Julio, Cokelaer, Thomas, Vedenko, Anastasia, Talukder, Shaheynoor, Bussemaker, Harmen J, Morris, Quaid D, Bulyk, Martha L, Stolovitzky, Gustavo, Hughes, Timothy R

“…The most comprehensive analysis to date of models of transcription-factor binding specificity reveals the best methods for predicting in vivo binding from in…”
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Information capacity of genetic regulatory elements Autor Tkačik, Gašper, Callan, Curtis G., Bialek, William

“…Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn…”
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D-brane approach to black hole quantum mechanics Autor Callan, Curtis G., Maldacena, Juan M.

“…Strominger and Vafa have used D-brane technology to identify and precisely count the degenerate quantum states responsible for the entropy of certain extremal,…”
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Repertoire sequencing and the statistical ensemble approach to adaptive immunity Autor Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.

“…The recent advent of high-throughput sequencing of immune receptors allows for the study of immune repertoires in unprecedented depth. This should eventually…”
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Field Theories for Learning Probability Distributions Autor Bialek, W, Callan, CG, Strong, SP

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Measures of epitope binding degeneracy from T cell receptor repertoires Autor Mayer, Andreas, Callan, Curtis G

“…Adaptive immunity is driven by specific binding of hyper-variable receptors to diverse molecular targets. The sequence diversity of receptors and targets are…”
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