Suchergebnisse - "Calabresi, Peter A"

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity von Kornberg, Michael D, Bhargava, Pavan, Kim, Paul M, Putluri, Vasanta, Snowman, Adele M, Putluri, Nagireddy, Calabresi, Peter A, Snyder, Solomon H

“… Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, thereby presenting a potential therapeutic target in …”
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A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis von Absinta, Martina, Maric, Dragan, Gharagozloo, Marjan, Garton, Thomas, Smith, Matthew D., Jin, Jing, Fitzgerald, Kathryn C., Song, Anya, Liu, Poching, Lin, Jing-Ping, Wu, Tianxia, Johnson, Kory R., McGavern, Dorian B., Schafer, Dorothy P., Calabresi, Peter A., Reich, Daniel S.

“… Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour ongoing demyelination and axon degeneration, and are identifiable in …”
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Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination von Kirby, Leslie, Jin, Jing, Cardona, Jaime Gonzalez, Smith, Matthew D., Martin, Kyle A., Wang, Jingya, Strasburger, Hayley, Herbst, Leyla, Alexis, Maya, Karnell, Jodi, Davidson, Todd, Dutta, Ranjan, Goverman, Joan, Bergles, Dwight, Calabresi, Peter A.

“… Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin …”
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Diffusion‐time dependence of diffusional kurtosis in the mouse brain von Aggarwal, Manisha, Smith, Matthew D., Calabresi, Peter A.

“… Purpose To investigate diffusion‐time dependency of diffusional kurtosis in the mouse brain using pulsed‐gradient spin‐echo (PGSE) and oscillating‐gradient …”
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Imaging chronic active lesions in multiple sclerosis: a consensus statement von Bagnato, Francesca, Sati, Pascal, Hemond, Christopher C, Elliott, Colm, Gauthier, Susan A, Harrison, Daniel M, Mainero, Caterina, Oh, Jiwon, Pitt, David, Shinohara, Russell T, Smith, Seth A, Trapp, Bruce, Azevedo, Christina J, Calabresi, Peter A, Henry, Roland G, Laule, Cornelia, Ontaneda, Daniel, Rooney, William D, Sicotte, Nancy L, Reich, Daniel S, Absinta, Martina

“… Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological …”
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Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis von Petzold, Axel, de Boer, Johannes F, Schippling, Sven, Vermersch, Patrik, Kardon, Randy, Green, Ari, Calabresi, Peter A, Polman, Chris

“… Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal …”
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Synaptic and complement markers in extracellular vesicles in multiple sclerosis von Bhargava, Pavan, Nogueras-Ortiz, Carlos, Kim, Sol, Delgado-Peraza, Francheska, Calabresi, Peter A, Kapogiannis, Dimitrios

“… Synaptic loss is a feature of multiple sclerosis pathology that can be seen even in normal-appearing gray matter. Opsonization of synapses with complement …”
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Structured layer surface segmentation for retina OCT using fully convolutional regression networks von He, Yufan, Carass, Aaron, Liu, Yihao, Jedynak, Bruno M., Solomon, Sharon D., Saidha, Shiv, Calabresi, Peter A., Prince, Jerry L.

“… •A novel formulation of deep network to output continuous, smooth and topology correct surfaces without post-processing.•End-to-end optimization of multiple …”
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DeepHarmony: A deep learning approach to contrast harmonization across scanner changes von Dewey, Blake E., Zhao, Can, Reinhold, Jacob C., Carass, Aaron, Fitzgerald, Kathryn C., Sotirchos, Elias S., Saidha, Shiv, Oh, Jiwon, Pham, Dzung L., Calabresi, Peter A., van Zijl, Peter C.M., Prince, Jerry L.

“… Magnetic resonance imaging (MRI) is a flexible medical imaging modality that often lacks reproducibility between protocols and scanners. It has been shown that …”
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Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior von Linville, Raleigh M., DeStefano, Jackson G., Sklar, Matt B., Xu, Zinnia, Farrell, Alanna M., Bogorad, Max I., Chu, Chengyan, Walczak, Piotr, Cheng, Linzhao, Mahairaki, Vasiliki, Whartenby, Katharine A., Calabresi, Peter A., Searson, Peter C.

“… Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major …”
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Imaging meningeal inflammation in CNS autoimmunity identifies a therapeutic role for BTK inhibition von Bhargava, Pavan, Kim, Sol, Reyes, Arthur A, Grenningloh, Roland, Boschert, Ursula, Absinta, Martina, Pardo, Carlos, Zijl, Peter Van, Zhang, Jiangyang, Calabresi, Peter A

“… Leptomeningeal inflammation in multiple sclerosis is associated with worse clinical outcomes and greater cortical pathology. Despite progress in identifying …”
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Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial von Calabresi, Peter A, Radue, Ernst-Wilhelm, Goodin, Douglas, Jeffery, Douglas, Rammohan, Kottil W, Reder, Anthony T, Vollmer, Timothy, Agius, Mark A, Kappos, Ludwig, Stites, Tracy, Li, Bingbing, Cappiello, Linda, von Rosenstiel, Philipp, Lublin, Fred D

“… Fingolimod has shown reductions in clinical and MRI disease activity in patients with relapsing-remitting multiple sclerosis. We further assessed the efficacy …”
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PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R) von Horti, Andrew G, Naik, Ravi, Foss, Catherine A, Minn, Il, Misheneva, Varia, Du, Yong, Wang, Yuchuan, Mathews, William B, Wu, Yunkou, Hall, Andrew, LaCourse, Catherine, Ahn, Hye-Hyun, Nam, Hwanhee, Lesniak, Wojciech G, Valentine, Heather, Pletnikova, Olga, Troncoso, Juan C, Smith, Matthew D, Calabresi, Peter A, Savonenko, Alena V, Dannals, Robert F, Pletnikov, Mikhail V, Pomper, Martin G

“… While neuroinflammation is an evolving concept and the cells involved and their functions are being defined, microglia are understood to be a key cellular …”
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Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study von Calabresi, Peter A, Kieseier, Bernd C, Arnold, Douglas L, Balcer, Laura J, Boyko, Alexey, Pelletier, Jean, Liu, Shifang, Zhu, Ying, Seddighzadeh, Ali, Hung, Serena, Deykin, Aaron

“… Subcutaneous pegylated interferon (peginterferon) beta-1a is being developed for treatment of relapsing multiple sclerosis, with less frequent dosing than …”
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Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein von Johnson, Tory P, Patel, Karan, Johnson, Kory R, Maric, Dragan, Calabresi, Peter A, Hasbun, Rodrigo, Nath, Avindra

“… Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV infection and can cause a devastating immune reconstitution …”
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Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management von Freedman, Mark S., Gnanapavan, Sharmilee, Booth, Ronald A., Calabresi, Peter A., Khalil, Michael, Kuhle, Jens, Lycke, Jan, Olsson, Tomas

“… Neurofilament light chain (NfL) is a long-awaited blood biomarker that can provide clinically useful information about prognosis and therapeutic efficacy in …”
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Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis von Gharagozloo, Marjan, Mace, Jackson W., Calabresi, Peter A.

“… Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). In people with MS, …”
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AQP4-IgG and MOG-IgG Related Optic Neuritis—Prevalence, Optical Coherence Tomography Findings, and Visual Outcomes: A Systematic Review and Meta-Analysis von Filippatou, Angeliki G., Mukharesh, Loulwah, Saidha, Shiv, Calabresi, Peter A., Sotirchos, Elias S.

“… Background: Optic neuritis (ON) is a cardinal manifestation of multiple sclerosis (MS), aquaporin-4 (AQP4)-IgG-, and myelin oligodendrocyte glycoprotein …”
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Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis von Sotirchos, Elias S, Bhargava, Pavan, Eckstein, Christopher, Van Haren, Keith, Baynes, Moira, Ntranos, Achilles, Gocke, Anne, Steinman, Lawrence, Mowry, Ellen M, Calabresi, Peter A

“… To study the safety profile and characterize the immunologic effects of high- vs low-dose cholecalciferol supplementation in patients with multiple sclerosis …”
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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial von Kappos, Ludwig, Li, David, Calabresi, Peter A, O'Connor, Paul, Bar-Or, Amit, Barkhof, Frederik, Yin, Ming, Leppert, David, Glanzman, Robert, Tinbergen, Jeroen, Hauser, Stephen L

“… B lymphocytes are implicated in the pathogenesis of multiple sclerosis. We aimed to assess efficacy and safety of two dose regimens of the humanised anti-CD20 …”
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