Suchergebnisse - "Caenorhabditis elegans metabolism"

The Gene Ontology resource: enriching a GOld mine von Carbon, Seth, Douglass, Eric, Good, Benjamin M, Unni, Deepak R, Harris, Nomi L, Mungall, Christopher J, Basu, Siddartha, Chisholm, Rex L, Dodson, Robert J, Hartline, Eric, Fey, Petra, Thomas, Paul D, Albou, Laurent-Philippe, Ebert, Dustin, Kesling, Michael J, Mi, Huaiyu, Muruganujan, Anushya, Huang, Xiaosong, Mushayahama, Tremayne, LaBonte, Sandra A, Siegele, Deborah A, Antonazzo, Giulia, Attrill, Helen, Brown, Nick H, Garapati, Phani, Marygold, Steven J, Trovisco, Vitor, dos Santos, Gil, Falls, Kathleen, Tabone, Christopher, Zhou, Pinglei, Goodman, Joshua L, Strelets, Victor B, Thurmond, Jim, Garmiri, Penelope, Ishtiaq, Rizwan, Rodríguez-López, Milagros, Acencio, Marcio L, Kuiper, Martin, Lægreid, Astrid, Logie, Colin, Lovering, Ruth C, Kramarz, Barbara, Saverimuttu, Shirin C C, Pinheiro, Sandra M, Gunn, Heather, Su, Renzhi, Thurlow, Katherine E, Chibucos, Marcus, Giglio, Michelle, Nadendla, Suvarna, Munro, James, Jackson, Rebecca, Duesbury, Margaret J, Del-Toro, Noemi, Meldal, Birgit H M, Paneerselvam, Kalpana, Perfetto, Livia, Porras, Pablo, Orchard, Sandra, Shrivastava, Anjali, Chang, Hsin-Yu, Finn, Robert Daniel, Mitchell, Alexander Lawson, Rawlings, Neil David, Richardson, Lorna, Sangrador-Vegas, Amaia, Blake, Judith A, Christie, Karen R, Dolan, Mary E, Drabkin, Harold J, Hill, David P, Ni, Li, Sitnikov, Dmitry M, Harris, Midori A, Oliver, Stephen G, Rutherford, Kim, Wood, Valerie, Hayles, Jaqueline, Bähler, Jürg, Bolton, Elizabeth R, De Pons, Jeffery L, Dwinell, Melinda R, Hayman, G Thomas, Kaldunski, Mary L, Kwitek, Anne E, Laulederkind, Stanley J F, Plasterer, Cody, Tutaj, Marek A, Vedi, Mahima, Wang, Shur-Jen, D’Eustachio, Peter, Matthews, Lisa, Balhoff, James P, Aleksander, Suzi A, Alexander, Michael J, Cherry, J Michael, Engel, Stacia R, Gondwe, Felix, Karra, Kalpana

“… Abstract The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of …”
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The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality von Chaudhuri, Jyotiska, Bains, Yasmin, Guha, Sanjib, Kahn, Arnold, Hall, David, Bose, Neelanjan, Gugliucci, Alejandro, Kapahi, Pankaj

“… Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and peptides/proteins are an inevitable component of the aging process in all …”
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Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor von Wei, Yongjie, Chiang, Wei-Chung, Sumpter, Jr, Rhea, Mishra, Prashant, Levine, Beth

“… The removal of unwanted or damaged mitochondria by autophagy, a process called mitophagy, is essential for key events in development, cellular homeostasis, …”
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Regulation of biomolecular condensates by interfacial protein clusters von Folkmann, Andrew W, Putnam, Andrea, Lee, Chiu Fan, Seydoux, Geraldine

“… Biomolecular condensates are cellular compartments that can form by phase separation in the absence of limiting membranes. Studying the P granules of , we find …”
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Molecular topography of an entire nervous system von Taylor, Seth R, Santpere, Gabriel, Weinreb, Alexis, Barrett, Alec, Reilly, Molly B, Xu, Chuan, Varol, Erdem, Oikonomou, Panos, Glenwinkel, Lori, McWhirter, Rebecca, Poff, Abigail, Basavaraju, Manasa, Rafi, Ibnul, Yemini, Eviatar, Cook, Steven J, Abrams, Alexander, Vidal, Berta, Cros, Cyril, Tavazoie, Saeed, Sestan, Nenad, Hammarlund, Marc, Hobert, Oliver, Miller, 3rd, David M

“… We have produced gene expression profiles of all 302 neurons of the C. elegans nervous system that match the single-cell resolution of its anatomy and wiring …”
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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease von Kumar, Deepak Kumar Vijaya, Choi, Se Hoon, Washicosky, Kevin J, Eimer, William A, Tucker, Stephanie, Ghofrani, Jessica, Lefkowitz, Aaron, McColl, Gawain, Goldstein, Lee E, Tanzi, Rudolph E, Moir, Robert D

“… The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We previously reported in vitro evidence suggesting that Aβ is an …”
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Whole-animal connectomes of both Caenorhabditis elegans sexes von Cook, Steven J., Jarrell, Travis A., Brittin, Christopher A., Wang, Yi, Bloniarz, Adam E., Yakovlev, Maksim A., Nguyen, Ken C. Q., Tang, Leo T.-H., Bayer, Emily A., Duerr, Janet S., Bülow, Hannes E., Hobert, Oliver, Hall, David H., Emmons, Scott W.

“… Knowledge of connectivity in the nervous system is essential to understanding its function. Here we describe connectomes for both adult sexes of the nematode …”
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Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants von Barucci, Giorgia, Cornes, Eric, Singh, Meetali, Li, Blaise, Ugolini, Martino, Samolygo, Aleksei, Didier, Celine, Dingli, Florent, Loew, Damarys, Quarato, Piergiuseppe, Cecere, Germano

“… PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive elements (REs) …”
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Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly von Gama, José B, Pereira, Cláudia, Simões, Patrícia A, Celestino, Ricardo, Reis, Rita M, Barbosa, Daniel J, Pires, Helena R, Carvalho, Cátia, Amorim, João, Carvalho, Ana X, Cheerambathur, Dhanya K, Gassmann, Reto

“… The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle microtubule capture and to control …”
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Low-dose metformin targets the lysosomal AMPK pathway through PEN2 von Ma, Teng, Tian, Xiao, Zhang, Baoding, Li, Mengqi, Wang, Yu, Yang, Chunyan, Wu, Jianfeng, Wei, Xiaoyan, Qu, Qi, Yu, Yaxin, Long, Shating, Feng, Jin-Wei, Li, Chun, Zhang, Cixiong, Xie, Changchuan, Wu, Yaying, Xu, Zheni, Chen, Junjie, Yu, Yong, Huang, Xi, He, Ying, Yao, Luming, Zhang, Lei, Zhu, Mingxia, Wang, Wen, Wang, Zhi-Chao, Zhang, Mingliang, Bao, Yuqian, Jia, Weiping, Lin, Shu-Yong, Ye, Zhiyun, Piao, Hai-Long, Deng, Xianming, Zhang, Chen-Song, Lin, Sheng-Cai

“… Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of …”
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Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition von Gaurav, Kumar, Busetto, Virginia, Páez-Moscoso, Diego Javier, Changiarath, Arya, Hanson, Sonya M, Falk, Sebastian, Ketting, René F, Stelzl, Lukas S

“… Phase separation of proteins plays a critical role in cellular organization. How phase-separated protein condensates underpin biological function and how …”
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Bioaccumulation of therapeutic drugs by human gut bacteria von Klünemann, Martina, Andrejev, Sergej, Blasche, Sonja, Mateus, Andre, Phapale, Prasad, Devendran, Saravanan, Vappiani, Johanna, Simon, Bernd, Scott, Timothy A., Kafkia, Eleni, Konstantinidis, Dimitrios, Zirngibl, Katharina, Mastrorilli, Eleonora, Banzhaf, Manuel, Mackmull, Marie-Therese, Hövelmann, Felix, Nesme, Leo, Brochado, Ana Rita, Maier, Lisa, Bock, Thomas, Periwal, Vinita, Kumar, Manjeet, Kim, Yongkyu, Tramontano, Melanie, Schultz, Carsten, Beck, Martin, Hennig, Janosch, Zimmermann, Michael, Sévin, Daniel C., Cabreiro, Filipe, Savitski, Mikhail M., Bork, Peer, Typas, Athanasios, Patil, Kiran R.

“… Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and …”
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Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis von Stein, Kevin C., Morales-Polanco, Fabián, van der Lienden, Joris, Rainbolt, T. Kelly, Frydman, Judith

“… Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-related protein misfolding diseases 1 , 2 . Yet, how ageing impairs …”
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Quantitative imaging of Caenorhabditis elegans dauer larvae during cryptobiotic transition von Kim, Kyoohyun, Gade, Vamshidhar R, Kurzchalia, Teymuras V, Guck, Jochen

“… Upon starvation or overcrowding, the nematode Caenorhabditis elegans enters diapause by forming a dauer larva, which can then further survive harsh desiccation …”
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The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR von Fiorese, Christopher J, Schulz, Anna M, Lin, Yi-Fan, Rosin, Nadine, Pellegrino, Mark W, Haynes, Cole M

“… Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration, diabetes, cancer, and pathogen infections as well as during normal …”
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An integrated view of innate immune mechanisms in C. elegans von Harding, Benjamin W, Ewbank, Jonathan J

“… The simple notion 'infection causes an immune response' is being progressively refined as it becomes clear that immune mechanisms cannot be understood in …”
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Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning von Gessulat, Siegfried, Schmidt, Tobias, Zolg, Daniel Paul, Samaras, Patroklos, Schnatbaum, Karsten, Zerweck, Johannes, Knaute, Tobias, Rechenberger, Julia, Delanghe, Bernard, Huhmer, Andreas, Reimer, Ulf, Ehrlich, Hans-Christian, Aiche, Stephan, Kuster, Bernhard, Wilhelm, Mathias

“… In mass-spectrometry-based proteomics, the identification and quantification of peptides and proteins heavily rely on sequence database searching or spectral …”
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Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity von Nedialkova, Danny D, Leidel, Sebastian A

“… Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but …”
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Lipid and Carbohydrate Metabolism in Caenorhabditis elegans von Watts, Jennifer L, Ristow, Michael

“… Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all aspects of organismal biology. eat bacteria, which consist of lipids, …”
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NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair von Fang, Evandro Fei, Kassahun, Henok, Croteau, Deborah L, Scheibye-Knudsen, Morten, Marosi, Krisztina, Lu, Huiming, Shamanna, Raghavendra A, Kalyanasundaram, Sumana, Bollineni, Ravi Chand, Wilson, Mark A, Iser, Wendy B, Wollman, Bradley N, Morevati, Marya, Li, Jun, Kerr, Jesse S, Lu, Qiping, Waltz, Tyler B, Tian, Jane, Sinclair, David A, Mattson, Mark P, Nilsen, Hilde, Bohr, Vilhelm A

“… Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked …”
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