Výsledky vyhľadávania - "CNS drugs"

The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond Autor Löscher, Wolfgang, Klein, Pavel

“…Epilepsy is one of the most common and disabling chronic neurological disorders. Antiseizure medications (ASMs), previously referred to as anticonvulsant or…”
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Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment Autor Mazza, Mario Gennaro, Palladini, Mariagrazia, Poletti, Sara, Benedetti, Francesco

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A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects Autor Taylor, Lesley, Gidal, Barry, Blakey, Graham, Tayo, Bola, Morrison, Gilmour

“…Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and…”
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Opioid-Induced Tolerance and Hyperalgesia Autor Mercadante, Sebastiano, Arcuri, Edoardo, Santoni, Angela

“…Opioids are very potent and efficacious drugs, traditionally used for both acute and chronic pain conditions. However, the use of opioids is frequently…”
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Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies Autor Strzelczyk, Adam, Schubert-Bast, Susanne

“…The developmental and epileptic encephalopathies encompass a group of rare syndromes characterised by severe drug-resistant epilepsy with onset in childhood…”
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Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment Autor Mazza, Mario Gennaro, Palladini, Mariagrazia, Poletti, Sara, Benedetti, Francesco

“…The Coronavirus Disease 2019 (COVID-19) pandemic is still spreading worldwide over 2 years since its outbreak. The psychopathological implications in COVID-19…”
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A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia Autor Correll, C. U., Agid, Ofer, Crespo-Facorro, Benedicto, de Bartolomeis, Andrea, Fagiolini, Andrea, Seppälä, Niko, Howes, Oliver D.

“…Treatment-resistant schizophrenia (TRS) will affect about one in three patients with schizophrenia. Clozapine is the only treatment approved for TRS, and…”
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Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain Autor Patel, Mayur M., Patel, Bhoomika M.

“…CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these…”
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Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review Autor Siefried, Krista J., Acheson, Liam S., Lintzeris, Nicholas, Ezard, Nadine

“…Background Stimulant drugs are second only to cannabis as the most widely used class of illicit drug globally, accounting for 68 million past-year consumers…”
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Neurotoxicity Associated with CD19-Targeted CAR-T Cell Therapies Autor Gust, Juliane, Taraseviciute, Agne, Turtle, Cameron J.

“…Neurotoxicity is an important and common complication of chimeric antigen receptor-T cell therapies. Acute neurologic signs and/or symptoms occur in a…”
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Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview Autor Correll, Christoph U., Kim, Edward, Sliwa, Jennifer Kern, Hamm, Wayne, Gopal, Srihari, Mathews, Maju, Venkatasubramanian, Raja, Saklad, Stephen R.

“…The availability of long-acting injectable (LAI) antipsychotics for the treatment of schizophrenia provides clinicians with options that deliver continuous…”
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Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability Autor Kienitz, Ricardo, Kay, Lara, Beuchat, Isabelle, Gelhard, Sarah, von Brauchitsch, Sophie, Mann, Catrin, Lucaciu, Alexandra, Schäfer, Jan-Hendrik, Siebenbrodt, Kai, Zöllner, Johann-Philipp, Schubert-Bast, Susanne, Rosenow, Felix, Strzelczyk, Adam, Willems, Laurent M.

“…Status epilepticus (SE) is an acute, life-threatening medical condition that requires immediate, effective therapy. Therefore, the acute care of prolonged…”
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Pharmacology of Cenobamate: Mechanism of Action, Pharmacokinetics, Drug–Drug Interactions and Tolerability Autor Roberti, Roberta, De Caro, Carmen, Iannone, Luigi Francesco, Zaccara, Gaetano, Lattanzi, Simona, Russo, Emilio

“…Cenobamate is one of the latest antiseizure medications (ASMs) developed for the treatment of focal onset seizures in adult patients. The recommended starting…”
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Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status Autor Henter, Ioline D., Park, Lawrence T., Zarate, Carlos A.

“…The efficacy of standard antidepressants is limited for many patients with mood disorders such as major depressive disorder (MDD) and bipolar depression,…”
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Intranasal Insulin for Alzheimer’s Disease Autor Hallschmid, Manfred

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High-Efficacy Therapies for Treatment-Naïve Individuals with Relapsing–Remitting Multiple Sclerosis Autor Freeman, Léorah, Longbrake, Erin E., Coyle, Patricia K., Hendin, Barry, Vollmer, Timothy

“…There are > 18 distinct disease-modifying therapy (DMT) options covering 10 mechanisms of action currently approved by the US Food and Drug Administration for…”
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Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies Autor Breeksema, Joost J., Niemeijer, Alistair R., Krediet, Erwin, Vermetten, Eric, Schoevers, Robert A.

“…Introduction Interest in the use of psychedelic substances for the treatment of mental disorders is increasing. Processes that may affect therapeutic change…”
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Apomorphine for Parkinson’s Disease: Efficacy and Safety of Current and New Formulations Autor Carbone, Federico, Djamshidian, Atbin, Seppi, Klaus, Poewe, Werner

“…Satisfactory management of Parkinson’s disease is a challenge that requires a tailored approach for each individual. In the advanced phase of the disease,…”
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Intranasal Insulin for Alzheimer’s Disease Autor Hallschmid, Manfred

“…Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including Alzheimer’s…”
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COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies Autor Reder, Anthony T., Centonze, Diego, Naylor, Maria L., Nagpal, Anjali, Rajbhandari, Rajani, Altincatal, Arman, Kim, Michelle, Berdofe, Aaron, Radhakrishnan, Maha, Jung, Eunice, Sandrock, Alfred W., Smirnakis, Karen, Popescu, Catrinel, de Moor, Carl

“…Background Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase the risk of severe acute…”
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