Suchergebnisse - "Burkart, Michael D."

Unraveling the Structure and Function of Melanin through Synthesis von Cao, Wei, Zhou, Xuhao, McCallum, Naneki C, Hu, Ziying, Ni, Qing Zhe, Kapoor, Utkarsh, Heil, Christian M, Cay, Kristine S, Zand, Tara, Mantanona, Alex J, Jayaraman, Arthi, Dhinojwala, Ali, Deheyn, Dimitri D, Shawkey, Matthew D, Burkart, Michael D, Rinehart, Jeffrey D, Gianneschi, Nathan C

“… Melanin is ubiquitous in living organisms across different biological kingdoms of life, making it an important, natural biomaterial. Its presence in nature …”
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Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom von Mindrebo, Jeffrey T, Nartey, Charisse M, Seto, Yoshiya, Burkart, Michael D, Noel, Joseph P

“… •Alpha/beta hydrolases play key roles in plant primary and specialized metabolism.•Unexpected catalytic functions for alpha/beta hydrolases found in …”
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The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life von Beld, Joris, Sonnenschein, Eva C, Vickery, Christopher R, Noel, Joseph P, Burkart, Michael D

“… Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not …”
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Charting the Complexity of the Marine Microbiome through Single-Cell Genomics von Pachiadaki, Maria G, Brown, Julia M, Brown, Joseph, Bezuidt, Oliver, Berube, Paul M, Biller, Steven J, Poulton, Nicole J, Burkart, Michael D, La Clair, James J, Chisholm, Sallie W, Stepanauskas, Ramunas

“… Marine bacteria and archaea play key roles in global biogeochemistry. To improve our understanding of this complex microbiome, we employed single-cell genomics …”
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Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology von Hur, Gene H, Vickery, Christopher R, Burkart, Michael D

“… Many pharmaceuticals on the market today belong to a large class of natural products called nonribosomal peptides (NRPs). Originating from bacteria and fungi, …”
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Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering von Beld, Joris, Lee, D John, Burkart, Michael D

“… Fatty acids are primary metabolites synthesized by complex, elegant, and essential biosynthetic machinery. Fatty acid synthases resemble an iterative assembly …”
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High Bio-Content Thermoplastic Polyurethanes from Azelaic Acid von Rajput, Bhausaheb S., Hai, Thien An Phung, Burkart, Michael D.

“… To realize the commercialization of sustainable materials, new polymers must be generated and systematically evaluated for material characteristics and …”
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Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm von Michaud, Jennifer M., Thompson, Luke R., Kaul, Drishti, Espinoza, Josh L., Richter, R. Alexander, Xu, Zhenjiang Zech, Lee, Christopher, Pham, Kevin M., Beall, Charlotte M., Malfatti, Francesca, Azam, Farooq, Knight, Rob, Burkart, Michael D., Dupont, Christopher L., Prather, Kimberly A.

“… Ocean-derived, airborne microbes play important roles in Earth’s climate system and human health, yet little is known about factors controlling their transfer …”
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Rapid biodegradation of microplastics generated from bio-based thermoplastic polyurethane von Allemann, Marco N., Tessman, Marissa, Reindel, Jaysen, Scofield, Gordon B., Evans, Payton, Pomeroy, Robert S., Burkart, Michael D., Mayfield, Stephen P., Simkovsky, Ryan

“… The accumulation of microplastics in various ecosystems has now been well documented and recent evidence suggests detrimental effects on various biological …”
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Discovering de novo peptide substrates for enzymes using machine learning von Tallorin, Lorillee, Wang, JiaLei, Kim, Woojoo E., Sahu, Swagat, Kosa, Nicolas M., Yang, Pu, Thompson, Matthew, Gilson, Michael K., Frazier, Peter I., Burkart, Michael D., Gianneschi, Nathan C.

“… The discovery of peptide substrates for enzymes with exclusive, selective activities is a central goal in chemical biology. In this paper, we develop a hybrid …”
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Structural basis for selectivity in a highly reducing type II polyketide synthase von Du, Danyao, Katsuyama, Yohei, Horiuchi, Masanobu, Fushinobu, Shinya, Chen, Aochiu, Davis, Tony D., Burkart, Michael D., Ohnishi, Yasuo

“… In type II polyketide synthases (PKSs), the ketosynthase–chain length factor (KS–CLF) complex catalyzes polyketide chain elongation with the acyl carrier …”
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Trapping the dynamic acyl carrier protein in fatty acid biosynthesis von Nguyen, Chi, Haushalter, Robert W., Lee, D. John, Markwick, Phineus R. L., Bruegger, Joel, Caldara-Festin, Grace, Finzel, Kara, Jackson, David R., Ishikawa, Fumihiro, O’Dowd, Bing, McCammon, J. Andrew, Opella, Stanley J., Tsai, Shiou-Chuan, Burkart, Michael D.

“… A highly specific chemical crosslinking method is used to trap a complex between an acyl carrier protein and a fatty acid dehydratase during fatty acid …”
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A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli von Hoogerland, Loles, van den Berg, Stefan Pieter Hendrik, Suo, Yixing, Moriuchi, Yuta W., Zoumaro-Djayoon, Adja, Geurken, Esther, Yang, Flora, Bruggeman, Frank, Burkart, Michael D., Bokinsky, Gregory

“… All free-living microorganisms homeostatically maintain the fluidity of their membranes by adapting lipid composition to environmental temperatures. Here, we …”
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Gating mechanism of elongating β-ketoacyl-ACP synthases von Mindrebo, Jeffrey T., Patel, Ashay, Kim, Woojoo E., Davis, Tony D., Chen, Aochiu, Bartholow, Thomas G., La Clair, James J., McCammon, J. Andrew, Noel, Joseph P., Burkart, Michael D.

“… Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, …”
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Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase von Jiang, Ziran, Heberlig, Graham W., Chen, Jeffrey A., Huynh, Jennifer, La Clair, James J., Burkart, Michael D.

“… Using a combination of dual covalent crosslinking and cryo-EM analyses, we elucidate the structure of mycocerosic acid synthase from Mycobacterium tuberculosis …”
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Manipulating Fatty Acid Biosynthesis in Microalgae for Biofuel through Protein-Protein Interactions von Blatti, Jillian L., Beld, Joris, Behnke, Craig A., Mendez, Michael, Mayfield, Stephen P., Burkart, Michael D.

“… Microalgae are a promising feedstock for renewable fuels, and algal metabolic engineering can lead to crop improvement, thus accelerating the development of …”
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Visualizing the Chain-Flipping Mechanism in Fatty-Acid Biosynthesis von Beld, Joris, Cang, Hu, Burkart, Michael D.

“… The acyl carrier protein (ACP) from fatty acid synthases sequesters elongating products within its hydrophobic core, but this dynamic mechanism remains poorly …”
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RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML von Crews, Leslie A, Balaian, Larisa, Delos Santos, Nathaniel P, Leu, Heather S, Court, Angela C, Lazzari, Elisa, Sadarangani, Anil, Zipeto, Maria A, La Clair, James J, Villa, Reymundo, Kulidjian, Anna, Storb, Rainer, Morris, Sheldon R, Ball, Edward D, Burkart, Michael D, Jamieson, Catriona H M

“… Age-related human hematopoietic stem cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoietic progenitor cells into …”
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Chemoenzymatic elaboration of the Raper-Mason pathway unravels the structural diversity within eumelanin pigments von Ni, Qing Zhe, Sierra, Brianna N, La Clair, James J, Burkart, Michael D

“… Melanin is a central polymer in living organisms, yet our understanding of its molecular structure remains unresolved. Here, we apply a biosynthetic approach …”
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Molecular basis for interactions between an acyl carrier protein and a ketosynthase von Milligan, Jacob C., Lee, D. John, Jackson, David R., Schaub, Andrew J., Beld, Joris, Barajas, Jesus F., Hale, Joseph J., Luo, Ray, Burkart, Michael D., Tsai, Shiou-Chuan

“… Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long hydrocarbon chains efficiently. Here we visualize the interaction between the …”
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