Výsledky vyhľadávania - "Buoninfante, Olimpia Alessandra"

DNA damage tolerance in hematopoietic stem and progenitor cells in mice Autor Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul, Lancini, Cesare, Song, Ji-Ying, Citterio, Elisabetta, Jacobs, Heinz

“…DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage…”
Zistit podrobnosti o prístupe

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect Autor de Groot, Daniel, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Lieftink, Cor, Catsman, Joyce J. I., Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul C. M., Beijersbergen, Roderick L., Jacobs, Heinz

“…Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two…”
Získať plný text

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity Autor Will Castro, Luiza S. E. P., Pieters, Wietske, Alemdehy, Mir Farshid, Aslam, Muhammad A., Buoninfante, Olimpia Alessandra, Raaijmakers, Jonne A., Pilzecker, Bas, van den Berk, Paul C. M., te Riele, Hein, Medema, René H., Pedrosa, Rozangela C., Jacobs, Heinz

“…The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors,…”
Získať plný text

DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy Autor Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Jacobs, Heinz

“…Abstract The DNA damage response network guards the stability of the genome from a plethora of exogenous and endogenous insults. An essential feature of the…”
Získať plný text

Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine Autor Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz

“…Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is…”
Získať plný text

Mammalian life depends on two distinct pathways of DNA damage tolerance Autor Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz

“…DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance…”
Zistit podrobnosti o prístupe

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis Autor Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Pritchard, Colin, Blomberg, Olga S., Huijbers, Ivo J., van den Berk, Paul C.M., Jacobs, Heinz

“…PrimPol is a DNA damage tolerant polymerase displaying both translesion synthesis (TLS) and (re)-priming properties. This led us to study the consequences of a…”
Získať plný text

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage Autor Wit, Niek, Buoninfante, Olimpia Alessandra, van den Berk, Paul C.M., Jansen, Jacob G., Hogenbirk, Marc A., de Wind, Niels, Jacobs, Heinz

“…Translesion synthesis (TLS) provides a highly conserved mechanism that enables DNA synthesis on a damaged template. TLS is performed by specialized DNA…”
Získať plný text

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system Autor Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C M, Jacobs, Heinz

“…DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink…”
Zistit podrobnosti o prístupe

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect Autor Groot, Daniel De, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Cor Lieftink Sr, Joyce Ji Catsman, Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Paul Cm Van Denberk, Beijersbergen, Roderick L, Jacobs, Heinz

“…DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. To determine the molecular and genomic impact of a global…”
Získať plný text