Výsledky vyhľadávania - "Buijze, Marijke"

An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells Autor de Roest, Reinout H., Buijze, Marijke, Veth, Myrthe, de Lint, Klaas, Pai, Govind, Rooimans, Martin A., Wolthuis, Rob M.F., Brink, Arjen, Poell, Jos B., Brakenhoff, Ruud H.

“…Radiotherapy is a mainstay of treatment for head and neck squamous cell carcinoma (HNSCC), either definitive or adjuvant to surgery. Biological factors known…”
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Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death Autor van Harten, Anne M., Buijze, Marijke, van der Mast, Richard, Rooimans, Martin A., Martens-de Kemp, Sanne R., Bachas, Costa, Brink, Arjen, Stigter-van Walsum, Marijke, Wolthuis, Rob M. F., Brakenhoff, Ruud H.

“…Head and neck squamous cell carcinomas (HNSCCs) coincide with poor survival rates. The lack of driver oncogenes complicates the development of targeted…”
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Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition Autor van Harten, Anne M., de Boer, D. Vicky, Martens-de Kemp, Sanne R., Buijze, Marijke, Ganzevles, Sonja H., Hunter, Keith D., Leemans, C. René, van Beusechem, Victor W., Wolthuis, Rob M. F., de Menezes, Renée X., Brakenhoff, Ruud H.

“…HPV-negative head and neck squamous cell carcinomas (HNSCCs) develop in precancerous changes in the mucosal lining of the upper-aerodigestive tract. These…”
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Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma Autor Holthof, Lisa C., van der Horst, Hilma J., van Hal-van Veen, Susan E., Ruiter, Ruud W.J., Li, Fengzhi, Buijze, Marijke, Andersen, Morten N., Yuan, Huipin, de Bruijn, Joost, van de Donk, Niels W.C.J., Lokhorst, Henk M., Zweegman, Sonja, Groen, Richard W.J., Mutis, Tuna

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Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients Autor van Harten, Anne M., Shah, Ronak, de Boer, D. Vicky, Buijze, Marijke, Kreft, Maaike, Song, Ji-Ying, Zürcher, Lisa M., Jacobs, Heinz, Brakenhoff, Ruud H.

“…Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA…”
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Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma Autor Lindenbergh-van der Plas, Marlon, Brakenhoff, Ruud H, Kuik, Dirk J, Buijze, Marijke, Bloemena, Elisabeth, Snijders, Peter J F, Leemans, C René, Braakhuis, Boudewijn J M

“…TP53 is a key gene in cellular homeostasis and is frequently mutated in head and neck squamous cell carcinoma (HNSCC). There is a variety of TP53 mutations,…”
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Genomic Engineering of Oral Keratinocytes to Establish In Vitro Oral Potentially Malignant Disease Models as a Platform for Treatment Investigation Autor Wils, Leon J., Buijze, Marijke, Stigter-van Walsum, Marijke, Brink, Arjen, van Kempen, Britt E., Peferoen, Laura, Brouns, Elisabeth R., de Visscher, Jan G. A. M., van der Meij, Erik H., Bloemena, Elisabeth, Poell, Jos B., Brakenhoff, Ruud H.

“…Precancerous cells in the oral cavity may appear as oral potentially malignant disorders, but they may also present as dysplasia without visual manifestation…”
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Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas Autor Schaaij-Visser, Tieneke B M, Graveland, A Peggy, Gauci, Sharon, Braakhuis, Boudewijn J M, Buijze, Marijke, Heck, Albert J R, Kuik, Dirk J, Bloemena, Elisabeth, Leemans, C René, Slijper, Monique, Brakenhoff, Ruud H

“…PURPOSE: The 5-year survival rates of head and neck squamous cell carcinomas (HNSCC) remain disappointing. HNSCCs develop in precursor fields of genetically…”
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Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining Autor de Boer, D Vicky, Brink, Arjen, Buijze, Marijke, Stigter-van Walsum, Marijke, Hunter, Keith D, Ylstra, Bauke, Bloemena, Elisabeth, Leemans, C René, Brakenhoff, Ruud H

“…Head and neck squamous cell carcinomas (HNSCC) develop in fields of genetically altered cells. These fields are often dysplastic and a subset can be recognized…”
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Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass Autor van Harten, Anne M., Poell, Jos B., Buijze, Marijke, Brink, Arjen, Wells, Susanne I., René Leemans, C., Wolthuis, Rob M.F., Brakenhoff, Ruud H.

“…•Fanconi anemia (FA) derived HNSCC is molecularly very comparable to sporadic non-FA HNSCC.•VU-SCC-040 is a cell model representative for HPV-negative copy…”
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An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells Autor Reinout H. de Roest, Marijke Buijze, Myrthe Veth, Klaas de Lint, Govind Pai, Martin A. Rooimans, Rob M.F. Wolthuis, Arjen Brink, Jos B. Poell, Ruud H. Brakenhoff

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Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines Autor Nagel, Remco, Martens-de Kemp, Sanne R., Buijze, Marijke, Jacobs, Gerbren, Braakhuis, Boudewijn J.M., Brakenhoff, Ruud H.

“…Infection with the human papillomavirus (HPV) is an important risk factor for development of head and neck squamous cell carcinoma (HNSCC). Strikingly,…”
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Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC Autor Nagel, Remco, Stigter-van Walsum, Marijke, Buijze, Marijke, van den Berg, Jaap, van der Meulen, Ida H, Hodzic, Jasmina, Piersma, Sander R, Pham, Thang V, Jiménez, Connie R, van Beusechem, Victor W, Brakenhoff, Ruud H

“…Lung cancer is the most common cancer worldwide and on top of that has a very poor prognosis, which is reflected by a 5-year survival rate of 5% to 15%…”
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Targeting PLK1 as a novel chemopreventive approach to eradicate preneoplastic mucosal changes in the head and neck Autor de Boer, D Vicky, Martens-de Kemp, Sanne R, Buijze, Marijke, Stigter-van Walsum, Marijke, Bloemena, Elisabeth, Dietrich, Ralf, Leemans, C René, van Beusechem, Victor W, Braakhuis, Boudewijn J M, Brakenhoff, Ruud H

“…Head and neck squamous cell carcinomas (HNSCC) and local relapses thereof develop in preneoplastic fields in the mucosal linings of the upper aerodigestive…”
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Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma Autor Graveland, A. Peggy, Golusinski, Pawel J., Buijze, Marijke, Douma, Rinze, Sons, Nanet, Kuik, Dirk J., Bloemena, Elisabeth, Leemans, C. René, Brakenhoff, Ruud H., Braakhuis, Boudewijn J.M.

“…A major problem in head and neck cancer surgery is the high rate of local relapse (LR). In at least 25% of the surgically treated head and neck squamous cell…”
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Noninvasive molecular screening for oral precancer in Fanconi anemia patients Autor Smetsers, Stephanie E, Velleuer, Eunike, Dietrich, Ralf, Wu, Thijs, Brink, Arjen, Buijze, Marijke, Deeg, Dorly J H, Soulier, Jean, Leemans, C René, Braakhuis, Boudewijn J M, Brakenhoff, Ruud H

“…LOH at chromosome arms 3p, 9p, 11q, and 17p are well-established oncogenetic aberrations in oral precancerous lesions and promising biomarkers to monitor the…”
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