Výsledky vyhledávání - "Buffa, Francesca M"

Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity Autor Ke, May, Elshenawy, Badran, Sheldon, Helen, Arora, Anjali, Buffa, Francesca M

“…Almost all biomedical research to date has relied upon mean measurements from cell populations, however it is well established that what it is observed at this…”
Získat plný text

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation Autor Bensaad, Karim, Favaro, Elena, Lewis, Caroline A., Peck, Barrie, Lord, Simon, Collins, Jennifer M., Pinnick, Katherine E., Wigfield, Simon, Buffa, Francesca M., Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J.O., Karpe, Fredrik, Schulze, Almut, Harris, Adrian L.

“…An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3)…”
Získat plný text

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors Autor Dhawan, Andrew, Scott, Jacob G., Harris, Adrian L., Buffa, Francesca M.

“…microRNAs are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging and cancer, where…”
Získat plný text

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells Autor Favaro, Elena, Bensaad, Karim, Chong, Mei G, Tennant, Daniel A, Ferguson, David J P, Snell, Cameron, Steers, Graham, Turley, Helen, Li, Ji-Liang, Günther, Ulrich L, Buffa, Francesca M, McIntyre, Alan, Harris, Adrian L

“…Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment…”
Zjistit podrobnosti o přístupu

FANCD2 limits replication stress and genome instability in cells lacking BRCA2 Autor Michl, Johanna, Zimmer, Jutta, Buffa, Francesca M, McDermott, Ultan, Tarsounas, Madalena

“…Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled…”
Získat plný text

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis Autor Masiero, Massimo, Simões, Filipa Costa, Han, Hee Dong, Snell, Cameron, Peterkin, Tessa, Bridges, Esther, Mangala, Lingegowda S, Wu, Sherry Yen-Yao, Pradeep, Sunila, Li, Demin, Han, Cheng, Dalton, Heather, Lopez-Berestein, Gabriel, Tuynman, Jurriaan B, Mortensen, Neil, Li, Ji-Liang, Patient, Roger, Sood, Anil K, Banham, Alison H, Harris, Adrian L, Buffa, Francesca M

“…Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an…”
Zjistit podrobnosti o přístupu

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity Autor Bader, Samuel B, Ma, Tiffany S, Simpson, Charlotte J, Liang, Jiachen, Maezono, Sakura Eri B, Olcina, Monica M, Buffa, Francesca M, Hammond, Ester M

“…Abstract Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors…”
Získat plný text

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia Autor Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“…Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that…”
Získat plný text

Robustness and reproducibility for AI learning in biomedical sciences: RENOIR Autor Barberis, Alessandro, Aerts, Hugo J. W. L., Buffa, Francesca M.

“…Artificial intelligence (AI) techniques are increasingly applied across various domains, favoured by the growing acquisition and public availability of large,…”
Získat plný text

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma Autor Falletta, Paola, Sanchez-Del-Campo, Luis, Chauhan, Jagat, Effern, Maike, Kenyon, Amy, Kershaw, Christopher J, Siddaway, Robert, Lisle, Richard, Freter, Rasmus, Daniels, Matthew J, Lu, Xin, Tüting, Thomas, Middleton, Mark, Buffa, Francesca M, Willis, Anne E, Pavitt, Graham, Ronai, Ze'ev A, Sauka-Spengler, Tatjana, Hölzel, Michael, Goding, Colin R

“…The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and…”
Zjistit podrobnosti o přístupu

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization Autor Korpal, Manav, Ell, Brian J, Buffa, Francesca M, Ibrahim, Toni, Blanco, Mario A, Celià-Terrassa, Toni, Mercatali, Laura, Khan, Zia, Goodarzi, Hani, Hua, Yuling, Wei, Yong, Hu, Guohong, Garcia, Benjamin A, Ragoussis, Jiannis, Amadori, Dino, Harris, Adrian L, Kang, Yibin

“…The miR200 family regulates EMT through E-cadherin modulation and has been proposed to contribute to metastasis thusly. This report identifies a promoting role…”
Získat plný text

microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer Autor Buffa, Francesca M, Camps, Carme, Winchester, Laura, Snell, Cameron E, Gee, Harriet E, Sheldon, Helen, Taylor, Marian, Harris, Adrian L, Ragoussis, Jiannis

“…microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated…”
Zjistit podrobnosti o přístupu

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors Autor Moskwa, Patryk, Buffa, Francesca M, Pan, Yunfeng, Panchakshari, Rohit, Gottipati, Ponnari, Muschel, Ruth J, Beech, John, Kulshrestha, Ritu, Abdelmohsen, Kotb, Weinstock, David M, Gorospe, Myriam, Harris, Adrian L, Helleday, Thomas, Chowdhury, Dipanjan

“…Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1…”
Zjistit podrobnosti o přístupu

miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense Autor Pajic, Marina, Froio, Danielle, Daly, Sheridan, Doculara, Louise, Millar, Ewan, Graham, Peter H, Drury, Alison, Steinmann, Angela, de Bock, Charles E, Boulghourjian, Alice, Zaratzian, Anaiis, Carroll, Susan, Toohey, Joanne, O'Toole, Sandra A, Harris, Adrian L, Buffa, Francesca M, Gee, Harriet E, Hollway, Georgina E, Molloy, Timothy J

“…Radiotherapy is essential to the treatment of most solid tumors and acquired or innate resistance to this therapeutic modality is a major clinical problem…”
Zjistit podrobnosti o přístupu

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer Autor Yang, Jun, AlTahan, Alaa, Jones, Dylan T, Buffa, Francesca M, Bridges, Esther, Interiano, Rodrigo B, Qu, Chunxu, Vogt, Nathan, Li, Ji-Liang, Baban, Dilair, Ragoussis, Jiannis, Nicholson, Robert, Davidoff, Andrew M, Harris, Adrian L

“…A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our previous studies indicate that hypoxia-inducible factor 1α (HIF-1α)…”
Zjistit podrobnosti o přístupu

hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer Autor Camps, Carme, Buffa, Francesca M, Colella, Stefano, Moore, John, Sotiriou, Christos, Sheldon, Helen, Harris, Adrian L, Gleadle, Jonathan M, Ragoussis, Jiannis

“…MicroRNA (miRNA) expression alterations have been described in cancer. Many cancers are characterized by areas of hypoxia, enhanced hypoxia-inducible factor…”
Zjistit podrobnosti o přístupu

MITF controls the TCA cycle to modulate the melanoma hypoxia response Autor Louphrasitthiphol, Pakavarin, Ledaki, Ioanna, Chauhan, Jagat, Falletta, Paola, Siddaway, Robert, Buffa, Francesca M., Mole, David R., Soga, Tomoyoshi, Goding, Colin R.

“…In response to the dynamic intra‐tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the…”
Získat plný text

Hypoxia-induced SETX links replication stress with the unfolded protein response Autor Ramachandran, Shaliny, Ma, Tiffany S., Griffin, Jon, Ng, Natalie, Foskolou, Iosifina P., Hwang, Ming-Shih, Victori, Pedro, Cheng, Wei-Chen, Buffa, Francesca M., Leszczynska, Katarzyna B., El-Khamisy, Sherif F., Gromak, Natalia, Hammond, Ester M.

“…Tumour hypoxia is associated with poor patient prognosis and therapy resistance. A unique transcriptional response is initiated by hypoxia which includes the…”
Získat plný text

Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models Autor Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Machado, Nicole, Barberis, Alessandro, Prevo, Remko, McLaughlin, Martin, Buffa, Francesca M., Harrington, Kevin J., Higgins, Geoff S.

“…Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer…”
Získat plný text

New role of fat-free mass in cancer risk linked with genetic predisposition Autor Harris, Benjamin H. L., Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A., Lord, Simon R., Allen, Naomi E., Maughan, Tim S., Bryant, Richard J., Harris, Adrian L., Bond, Gareth L., Buffa, Francesca M.

“…Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may…”
Získat plný text