Výsledky vyhľadávania - "Brust, James C M"

TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis Autor Collins, Jeffrey M., Jones, Dean P., Sharma, Ashish, Khadka, Manoj, Liu, Ken H., Kempker, Russell R., Prideaux, Brendan, Maner-Smith, Kristal, Tukvadze, Nestani, Shah, N. Sarita, Brust, James C. M., Sékaly, Rafick-Pierre, Gandhi, Neel R., Blumberg, Henry M., Ortlund, Eric A., Ziegler, Thomas R.

“…The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using…”
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MDR-TB patients in KwaZulu-Natal, South Africa: Cost-effectiveness of 5 models of care Autor Loveday, Marian, Wallengren, Kristina, Reddy, Tarylee, Besada, Donela, Brust, James C. M., Voce, Anna, Desai, Harsha, Ngozo, Jacqueline, Radebe, Zanele, Master, Iqbal, Padayatchi, Nesri, Daviaud, Emmanuelle

“…South Africa has a high burden of MDR-TB, and to provide accessible treatment the government has introduced different models of care. We report the most…”
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High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa Autor Niehaus, Abraham J., Mlisana, Koleka, Gandhi, Neel R., Mathema, Barun, Brust, James C. M.

“…Drug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options…”
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Spatial distribution of extensively drug-resistant tuberculosis (XDR TB) patients in KwaZulu-Natal, South Africa Autor Kapwata, Thandi, Morris, Natashia, Campbell, Angela, Mthiyane, Thuli, Mpangase, Primrose, Nelson, Kristin N., Allana, Salim, Brust, James C. M., Moodley, Pravi, Mlisana, Koleka, Gandhi, Neel R., Shah, N. Sarita

“…KwaZulu-Natal province, South Africa, has among the highest burden of XDR TB worldwide with the majority of cases occurring due to transmission. Poor access to…”
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Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa Autor Lim, Jennifer R., Gandhi, Neel R., Mthiyane, Thuli, Mlisana, Koleka, Moodley, Julie, Jaglal, Prenika, Ramdin, Neeshan, Brust, James C. M., Ismail, Nazir, Rustomjee, Roxana, Shah, N. Sarita

“…South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds…”
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Old drugs, new purpose: retooling existing drugs for optimized treatment of resistant tuberculosis Autor Dooley, Kelly E, Mitnick, Carole D, Ann DeGroote, Mary, Obuku, Ekwaro, Belitsky, Vera, Hamilton, Carol D, Makhene, Mamodikoe, Shah, Sarita, Brust, James C M, Durakovic, Nadza, Nuermberger, Eric

“…Treatment of drug-resistant tuberculosis is hindered by the high toxicity and poor efficacy of second-line drugs. New compounds must be used together with…”
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Culture Conversion Among HIV Co-Infected Multidrug-Resistant Tuberculosis Patients in Tugela Ferry, South Africa Autor Brust, James C. M., Lygizos, Melissa, Chaiyachati, Krisda, Scott, Michelle, van der Merwe, Theo L., Moll, Anthony P., Li, Xuan, Loveday, Marian, Bamber, Sheila A., Lalloo, Umesh G., Friedland, Gerald H., Shah, N. Sarita, Gandhi, Neel R.

“…Little is known about the time to sputum culture conversion in MDR-TB patients co-infected with HIV, although such patients have, historically, had poor…”
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Transmission of Extensively Drug-Resistant Tuberculosis in South Africa Autor Shah, N. Sarita, Auld, Sara C, Brust, James C.M, Mathema, Barun, Ismail, Nazir, Moodley, Pravi, Mlisana, Koleka, Allana, Salim, Campbell, Angela, Mthiyane, Thuli, Morris, Natashia, Mpangase, Primrose, van der Meulen, Hermina, Omar, Shaheed V, Brown, Tyler S, Narechania, Apurva, Shaskina, Elena, Kapwata, Thandi, Kreiswirth, Barry, Gandhi, Neel R

“…This study from South Africa showed that extensively drug-resistant tuberculosis, an emerging global public health threat, is largely associated with…”
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Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis Autor Ngwalero, Precious, Brust, James C M, van Beek, Stijn W, Wasserman, Sean, Maartens, Gary, Meintjes, Graeme, Joubert, Anton, Norman, Jennifer, Castel, Sandra, Gandhi, Neel R, Denti, Paolo, McIlleron, Helen, Svensson, Elin M, Wiesner, Lubbe

“…Bedaquiline is recommended for the treatment of all patients with rifampin-resistant tuberculosis (RR-TB). Bedaquiline accumulates within cells, but its…”
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Linezolid Population Pharmacokinetics in South African Adults with Drug-Resistant Tuberculosis Autor Abdelwahab, Mahmoud Tareq, Wasserman, Sean, Brust, James C M, Dheda, Keertan, Wiesner, Lubbe, Gandhi, Neel R, Warren, Robin M, Sirgel, Frederick A, Meintjes, Graeme, Maartens, Gary, Denti, Paolo

“…Linezolid is widely used for drug-resistant tuberculosis (DR-TB) but has a narrow therapeutic index. To inform dose optimization, we aimed to characterize the…”
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Optimized Loading Dose Strategies for Bedaquiline When Restarting Interrupted Drug-Resistant Tuberculosis Treatment Autor Koele, Simon E, van Beek, Stijn W, Maartens, Gary, Brust, James C M, Svensson, Elin M

“…Interruption of treatment is common in drug-resistant tuberculosis patients. Bedaquiline has a long terminal half-life; therefore, restarting after an…”
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Five cases of bacteraemia due to Gordonia species Autor Brust, James C M, Whittier, Susan, Scully, Brian E, McGregor, Carlton C, Yin, Michael T

“…Gordonia species are aerobic Gram-positive bacilli and a rare cause of human disease. To our knowledge, there are only two cases of human infection with…”
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Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection Autor Wasserman, Sean, Denti, Paolo, Brust, James C M, Abdelwahab, Mahmoud, Hlungulu, Siphokazi, Wiesner, Lubbe, Norman, Jennifer, Sirgel, Frederick A, Warren, Robin M, Esmail, Aliasgar, Dheda, Keertan, Gandhi, Neel R, Meintjes, Graeme, Maartens, Gary

“…The World Health Organization (WHO) recently recommended that linezolid be prioritized in treatment regimens for drug-resistant tuberculosis (TB), but there…”
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Evidence-based Definition for Extensively Drug-Resistant Tuberculosis Autor Roelens, Maroussia, Battista Migliori, Giovanni, Rozanova, Liudmila, Estill, Janne, Campbell, Jonathon R, Cegielski, J Peter, Tiberi, Simon, Palmero, Domingo, Fox, Greg J, Guglielmetti, Lorenzo, Sotgiu, Giovanni, Brust, James C M, Bang, Didi, Lienhardt, Christian, Lange, Christoph, Menzies, Dick, Keiser, Olivia, Raviglione, Mario

“…Rationale: Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was defined as TB with resistance to rifampicin and isoniazid (multidrug-resistant TB…”
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Treatment Adherence Among Persons Receiving Concurrent Multidrug-Resistant Tuberculosis and HIV Treatment in KwaZulu-Natal, South Africa Autor Stephens, Fay, Gandhi, Neel R, Brust, James C M, Mlisana, Koleka, Moodley, Pravi, Allana, Salim, Campbell, Angie, Shah, Sarita

“…Success in multidrug-resistant tuberculosis (MDR-TB) and HIV treatment requires high medication adherence despite high pill burdens, frequent adverse events,…”
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Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa Autor Magee, Matthew J., Sun, Yan V., Brust, James C. M., Shah, N. Sarita, Ning, Yuming, Allana, Salim, Campbell, Angela, Hui, Qin, Mlisana, Koleka, Moodley, Pravi, Gandhi, Neel R.

“…Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin…”
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Association between Health Systems Performance and Treatment Outcomes in Patients Co-Infected with MDR-TB and HIV in KwaZulu-Natal, South Africa: Implications for TB Programmes Autor Loveday, Marian, Padayatchi, Nesri, Wallengren, Kristina, Roberts, Jacquelin, Brust, James C. M., Ngozo, Jacqueline, Master, Iqbal, Voce, Anna

“…To improve the treatment of MDR-TB and HIV co-infected patients, we investigated the relationship between health system performance and patient treatment…”
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Dilemma of managing asymptomatic children referred with ‘culture-confirmed’ drug-resistant tuberculosis Autor Loveday, Marian, Sunkari, Babu, Marais, Ben J, Master, Iqbal, Brust, James C M

“…BackgroundThe diagnosis of drug-resistant tuberculosis (DR-TB) in children is challenging and treatment is associated with many adverse effects.ObjectiveWe…”
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Adverse events in an integrated home-based treatment program for MDR-TB and HIV in KwaZulu-Natal, South Africa Autor Brust, James C M, Shah, N Sarita, van der Merwe, Theo L, Bamber, Sheila, Ning, Yuming, Heo, Moonseong, Moll, Anthony P, Loveday, Marian, Lalloo, Umesh G, Friedland, Gerald H, Gandhi, Neel R

“…Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The…”
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"Weighting" the Evidence: How Much Bedaquiline Is Enough? Autor Brust, James C M

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