Suchergebnisse - "Brunsveld, Luc"

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation von De Bosscher, Karolien, Desmet, Sofie J, Clarisse, Dorien, Estébanez-Perpiña, Eva, Brunsveld, Luc

“… Nuclear receptor crosstalk can be defined as the interplay between different nuclear receptors or between their overlapping signalling pathways. A subset of …”
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Modulators of protein-protein interactions von Milroy, Lech-Gustav, Grossmann, Tom N, Hennig, Sven, Brunsveld, Luc, Ottmann, Christian

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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions von Sijbesma, Eline, Visser, Emira, Plitzko, Kathrin, Thiel, Philipp, Milroy, Lech-Gustav, Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian

“… The systematic stabilization of protein–protein interactions (PPI) has great potential as innovative drug discovery strategy to target novel and hard-to-drug …”
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Modulators of 14-3-3 Protein-Protein Interactions von Stevers, Loes M, Sijbesma, Eline, Botta, Maurizio, MacKintosh, Carol, Obsil, Tomas, Landrieu, Isabelle, Cau, Ylenia, Wilson, Andrew J, Karawajczyk, Anna, Eickhoff, Jan, Davis, Jeremy, Hann, Michael, O'Mahony, Gavin, Doveston, Richard G, Brunsveld, Luc, Ottmann, Christian

“… Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of …”
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Hydrophobicity Directed Chiral Self‐Assembly and Aggregation‐Induced Emission: Diacetylene‐Cored Pseudopeptide Chiral Dopants von Maurya, Govind P., Verma, Deepak, Sinha, Aloka, Brunsveld, Luc, Haridas, V.

“… Here we delineate simple and tunable hydrophobically driven chiral functional assemblies of diacetylene cored pseudopeptides. These amino acid appended, rigid …”
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Metal-Free Photocatalytic Aerobic Oxidation of Thiols to Disulfides in Batch and Continuous-Flow von Talla, Ali, Driessen, Brian, Straathof, Natan J. W., Milroy, Lech-Gustav, Brunsveld, Luc, Hessel, Volker, Noël, Timothy

“… Disulfides represent significant molecular and structural features in various biologically active compounds and fine chemicals. Therefore, the development of …”
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Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs von Magdalena Estirado, Eva, Mason, Alexander F, Alemán García, Miguel Ángel, van Hest, Jan C M, Brunsveld, Luc

“… The programmed construction of functional synthetic cells requires spatial control over arrays of biomolecules within the cytomimetic environment. The mimicry …”
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A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14‐3‐3 von de Vink, Pim J., Briels, Jeroen M., Schrader, Thomas, Milroy, Lech‐Gustav, Brunsveld, Luc, Ottmann, Christian

“… Interactions between proteins frequently involve recognition sequences based on multivalent binding events. Dimeric 14‐3‐3 adapter proteins are a prominent …”
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The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface von Bier, David, Mittal, Sumit, Bravo-Rodriguez, Kenny, Sowislok, Andrea, Guillory, Xavier, Briels, Jeroen, Heid, Christian, Bartel, Maria, Wettig, Burkhard, Brunsveld, Luc, Sanchez-Garcia, Elsa, Schrader, Thomas, Ottmann, Christian

“… Protein regions that are involved in protein-protein interactions (PPIs) very often display a high degree of intrinsic disorder, which is reduced during the …”
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Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis von Bottecchia, Cecilia, Erdmann, Nico, Tijssen, Patricia M. A., Milroy, Lech-Gustav, Brunsveld, Luc, Hessel, Volker, Noël, Timothy

“… A mild and practical method for the preparation of disulfides through visible‐light‐induced photocatalytic aerobic oxidation of thiols has been developed. The …”
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Stabilization of protein-protein interactions in drug discovery von Andrei, Sebastian A., Sijbesma, Eline, Hann, Michael, Davis, Jeremy, O'Mahony, Gavin, Perry, Matthew W. D., Karawajczyk, Anna, Eickhoff, Jan, Brunsveld, Luc, Doveston, Richard G., Milroy, Lech-Gustav, Ottmann, Christian

“… Introduction: PPIs are involved in every disease and specific modulation of these PPIs with small molecules would significantly improve our prospects of …”
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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR von Stevers, Loes M., Wolter, Madita, Carlile, Graeme W., Macdonald, Dwight, Richard, Luc, Gielkens, Frank, Hanrahan, John W., Thomas, David Y., Chakka, Sai Kumar, Peterson, Mark L., Thomas, Helmut, Brunsveld, Luc, Ottmann, Christian

“… Impaired activity of the chloride channel CFTR is the cause of cystic fibrosis. 14-3-3 proteins have been shown to stabilize CFTR and increase its biogenesis …”
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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity von Katz, Liora S., Visser, Emira J., Plitzko, Kathrin F., Pennings, Marloes A. M., Cossar, Peter J., Tse, Isabelle L., Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian, Scott, Donald K.

“… The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In …”
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Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR von Stevers, Loes M, Lam, Chan V, Leysen, Seppe F R, Meijer, Femke A, van Scheppingen, Daphne S, de Vries, Rens M J M, Carlile, Graeme W, Milroy, Lech G, Thomas, David Y, Brunsveld, Luc, Ottmann, Christian

“… Cystic fibrosis is a fatal genetic disease, most frequently caused by the retention of the CFTR (cystic fibrosis transmembrane conductance regulator) mutant …”
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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex von Konstantinidou, Markella, Zingiridis, Marios, Pennings, Marloes A. M., Fragkiadakis, Michael, Virta, Johanna M., Revalde, Jezrael L., Visser, Emira J., Ottmann, Christian, Brunsveld, Luc, Neochoritis, Constantinos G., Arkin, Michelle R.

“… Molecular glues, small molecules that bind cooperatively at a protein-protein interface, have emerged as powerful modalities for the modulation of …”
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Evaluation of fluorophores to label SNAP-tag fused proteins for multicolor single-molecule tracking microscopy in live cells von Bosch, Peter J, Corrêa, Jr, Ivan R, Sonntag, Michael H, Ibach, Jenny, Brunsveld, Luc, Kanger, Johannes S, Subramaniam, Vinod

“… Single-molecule tracking has become a widely used technique for studying protein dynamics and their organization in the complex environment of the cell. In …”
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Automated navigation of condensate phase behavior with active machine learning von Leurs, Yannick H. A., van den Hout, Willem, Gardin, Andrea, van Dongen, Joost L. J., Rodriguez-Abetxuko, Andoni, Erkamp, Nadia A., van Hest, Jan C. M., Grisoni, Francesca, Brunsveld, Luc

“… Biomolecular condensates are essential cellular structures formed via biomacromolecule phase separation. Synthetic condensates allow for systematic engineering …”
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Stabilization and inhibition of protein-protein interactions: the 14-3-3 case study von Milroy, Lech-Gustav, Brunsveld, Luc, Ottmann, Christian

“… Small-molecule modulation of protein-protein interactions (PPIs) is one of the most exciting but also difficult fields in chemical biology and drug …”
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Small-molecule inhibition of APT1 affects Ras localization and signaling von Dekker, Frank J, Rocks, Oliver, Vartak, Nachiket, Menninger, Sascha, Hedberg, Christian, Balamurugan, Rengarajan, Wetzel, Stefan, Renner, Steffen, Gerauer, Marc, Schölermann, Beate, Rusch, Marion, Kramer, John W, Rauh, Daniel, Coates, Geoffrey W, Brunsveld, Luc, Bastiaens, Philippe I H, Waldmann, Herbert

“… Reversible palmitoylation controls the localization and signaling of Ras. Development of a potent and specific small molecule inhibitor of the thioesterase …”
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Cooperativity basis for small-molecule stabilization of protein-protein interactions von de Vink, Pim J, Andrei, Sebastian A, Higuchi, Yusuke, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

“… A cooperativity framework to describe and interpret small-molecule stabilization of protein-protein interactions (PPI) is presented. The stabilization of PPIs …”
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